Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways.

Autor: Kurmasheva N; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Said A; Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Wong B; Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Ottawa Hospital Research Insitute, Ottawa, ON, K1H 8L6, Canada., Kinderman P; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Han X; Lady Davis Institute, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Rahimic AHF; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Kress A; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; Faculty of Biological Sciences, Goethe University, 60438, Frankfurt am Main, Germany., Carter-Timofte ME; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Holm E; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., van der Horst D; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Kollmann CF; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Liu Z; Lady Davis Institute, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Wang C; Lady Davis Institute, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Hoang HD; Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Kovalenko E; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Chrysopoulou M; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Twayana KS; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Ottosen RN; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., Svenningsen EB; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., Begnini F; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., Kiib AE; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., Kromm FEH; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., Weiss HJ; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Ireland., Di Carlo D; Pasteur Laboratories, Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, 00161, Italy., Muscolini M; Pasteur Laboratories, Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, 00161, Italy., Higgins M; Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., van der Heijden M; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Bardoul A; Cancer Axis, CHUM Research Centre, Montreal, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, University of Montreal, Montreal, Canada.; Institut du Cancer de Montréal, Montreal, QC, Canada., Tong T; Department of Neurosurgery, Aarhus University Hospital, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.; DCCC Brain Tumor Center, Copenhagen University Hospital, Copenhagen, Denmark., Ozsvar A; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.; Department of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark., Hou WH; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Schack VR; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Holm CK; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark., Zheng Y; Small Molecule Therapeutics & Platform Technologies, AbbVie Inc., 1 North Waukegon Road, North Chicago, IL, 60064, USA., Ruzek M; AbbVie, Bioresearch Center, 100 Research Drive, Worcester, MA, 01608, USA., Kalucka J; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., de la Vega L; Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., Elgaher WAM; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, E8.1, 66123, Saarbrücken, Germany., Korshoej AR; Department of Neurosurgery, Aarhus University Hospital, 8200, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.; DCCC Brain Tumor Center, Copenhagen University Hospital, Copenhagen, Denmark., Lin R; Lady Davis Institute, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Hiscott J; Pasteur Laboratories, Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, 00161, Italy., Poulsen TB; Department of Chemistry, Aarhus University, 8000, Aarhus C, Denmark., O'Neill LA; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Ireland., Roy DG; Cancer Axis, CHUM Research Centre, Montreal, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, University of Montreal, Montreal, Canada.; Institut du Cancer de Montréal, Montreal, QC, Canada., Rinschen MM; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.; III. Department of Medicine and Hamburg Center for Kidney Health, Hamburg, Germany.; Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark., van Montfoort N; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Diallo JS; Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Ottawa Hospital Research Insitute, Ottawa, ON, K1H 8L6, Canada., Farin HF; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Frankfurt/Mainz partner site and German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Alain T; Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Olagnier D; Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark. olagnier@biomed.au.dk.

Publikováno v: Nature communications [Nat Commun] 2024 May 15; Vol. 15 (1), pp. 4096. Date of Electronic Publication: 2024 May 15.

Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster.

Autor: Lende SSF; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Barnkob NM; Symphogen, Ballerup, Denmark., Hansen RW; Symphogen, Ballerup, Denmark., Bansia H; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, United States of America., Vestergaard M; Symphogen, Ballerup, Denmark., Rothemejer FH; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Worsaae A; Symphogen, Ballerup, Denmark., Brown D; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, United States of America., Pedersen ML; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rahimic AHF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Juhl AK; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark., Gjetting T; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, United States of America.; Antibody Technology, Novo Nordisk A/S, Måløv, Denmark., Østergaard L; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Georges AD; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, United States of America.; Department of Chemistry and Biochemistry, City College of New York, New York, NY, United States of America.; PhD Programs in Biochemistry, and Chemistry, Graduate Center, City University of New York, New York, NY, United States of America., Vuillard LM; Servier, Suresnes, France., Schleimann MH; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark., Koefoed K; Symphogen, Ballerup, Denmark., Tolstrup M; Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Publikováno v: PloS one [PLoS One] 2023 Sep 20; Vol. 18 (9), pp. e0291131. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023).