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Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder

Autor: Adam C. Gower, Jiayi Wu Cox, Rahim Shafa, Hamid Mostafavi Abdolmaleky, Vadivelu Sivaraman, Sam Thiagalingam, Arunthathi Thiagalingam, Jin-Rong Zhou, Chen‐Khuan Wong, Xiaoling Zhang

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 180(2)

INTRODUCTION: Although the loss or reversal of brain laterality is one of the most consistent modalities in schizophrenia (SCZ) and bipolar disorder (BD), its molecular basis remains elusive. Our limited previous studies indicated that epigenetic mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9421bc0f75d8b4d4fe09ba1fa4d2cdf
https://pubmed.ncbi.nlm.nih.gov/30468562

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DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia

Autor: Chen Khuan Wong, Ashraf Mostafavi, Shabnam Nohesara, Mohammad Ghadirivasfi, Hamid Mostafavi Abdolmaleky, Sait Ozturk, Hamid Reza Ahmadkhaniha, Sam Thiagalingam, Arthur W. Lambert, Rahim Shafa

Publikováno v: Schizophr Res

Introduction Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2807dbc5bc34d01efc6aac6aef7eecd3
https://doi.org/10.1016/j.schres.2013.12.007

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Poster Abstracts from the AAAP 19th Annual Meeting and Symposium

Autor: Rahim Shafa

Publikováno v: American Journal on Addictions. 18:321-331

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d1e5a1069beebd5f6775f09d8c5cb88
https://doi.org/10.1080/10550490902928197

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Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder

Autor: Panagiotis Papageorgis, Hongjie Pan, Stephen V. Faraone, Batol Aeali, Kuang-hung Cheng, Jose F. Ponte, Fangming Gao, Stephen J. Glatt, Marsha A. Wilcox, Cassandra L. Smith, Ming T. Tsuang, Hamid Mostafavi Abdolmaleky, Rahim Shafa, Vadivelu Sivaraman, Julie Carnevale, Sam Thiagalingam

Publikováno v: Human Molecular Genetics. 15:3132-3145

The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered promoter DNA methylation cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f391cd8e50d044aa158c84c91953d49
https://doi.org/10.1093/hmg/ddl253

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Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: A preliminary report

Autor: Cassandra L. Smith, Rahim Shafa, Andrea L. Russo, Hamid Mostafavi Abdolmaleky, Stephen V. Faraone, Kuang-hung Cheng, Stephen J. Glatt, Sam Thiagalingam, Joe F. Ponte, Giang H. Nguyen, Marsha A. Wilcox, Ming T. Tsuang

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :60-66

DNA methylation changes could provide a mechanism for DNA plasticity and dynamism for short-term adaptation, enabling a type of cell memory to register cellular history under different environmental conditions. Some environmental insults may also res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c2ec2b2da18af1cac5a668c6b30c0f
https://doi.org/10.1002/ajmg.b.30140

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Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation

Autor: Rahim Shafa, Stephen J. Glatt, William S. Stone, Stephen V. Faraone, Ming T. Tsuang, Cassandra L. Smith, Hamid Mostafavi Abdolmaleky

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (1)

Fine-tuning of neuronal connections during development is regulated through environmental interactions. Some fine-tuning occurs through changes in gene expression and/or epigenetic gene-specific DNA methylation states. DNA methylation occurs by trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d91e3f1091fbf3f6dfcdb1fdf77981a
https://pubmed.ncbi.nlm.nih.gov/15108180

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