Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rahil Taujale"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Fructosamine-3-kinases (FN3Ks) are a conserved family of repair enzymes that phosphorylate reactive sugars attached to lysine residues in peptides and proteins. Although FN3Ks are present across the Tree of Life and share detectable sequence
Externí odkaz:
https://doaj.org/article/4538014328d94853bd8449e652e1b0c6
Autor:
Liang-Chin Huang, Rahil Taujale, Nathan Gravel, Aarya Venkat, Wayland Yeung, Dominic P. Byrne, Patrick A. Eyers, Natarajan Kannan
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human pro
Externí odkaz:
https://doaj.org/article/b48b08ad84734cd7aab992cc3ed2eb27
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Glycosyltransferases (GT) are proteins that display extensive sequence and functional variation on a subset of 3D folds. Here, the authors use interpretable deep learning to predict 3D folds from sequence without the need for sequence alignment, whic
Externí odkaz:
https://doaj.org/article/f5c17c58d05e4400857aec9c85fdb18c
Autor:
Nathaniel R. Beattie, Nicholas D. Keul, Tiffany N. Hicks Sirmans, Weston E. McDonald, Trevor M. Talmadge, Rahil Taujale, Natarajan Kannan, Zachary A. Wood
Publikováno v:
ACS Omega, Vol 4, Iss 15, Pp 16318-16329 (2019)
Externí odkaz:
https://doaj.org/article/f9fd84e8dfae499db21be3fa66c23b43
Autor:
Rahil Taujale, Aarya Venkat, Liang-Chin Huang, Zhongliang Zhou, Wayland Yeung, Khaled M Rasheed, Sheng Li, Arthur S Edison, Kelley W Moremen, Natarajan Kannan
Publikováno v:
eLife, Vol 9 (2020)
Glycosyltransferases (GTs) are prevalent across the tree of life and regulate nearly all aspects of cellular functions. The evolutionary basis for their complex and diverse modes of catalytic functions remain enigmatic. Here, based on deep mining of
Externí odkaz:
https://doaj.org/article/3af3aed9f09e483db012d4bc7e1b0006
Autor:
Celia Florimond, Charlotte Cordonnier, Rahil Taujale, Hanke van der Wel, Natarajan Kannan, Christopher M. West, Ira J. Blader
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT As the protozoan parasite Toxoplasma gondii disseminates through its host, it responds to environmental changes by altering its gene expression, metabolism, and other processes. Oxygen is one variable environmental factor, and properly adapt
Externí odkaz:
https://doaj.org/article/cce39d19a7444b7598a65d908272eb1c
Autor:
Rahil Taujale, Yanbin Yin
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128409 (2015)
The glycosyltransferase family 43 (GT43) has been suggested to be involved in the synthesis of xylans in plant cell walls and proteoglycans in animals. Very recently GT43 family was also found in Charophycean green algae (CGA), the closest relatives
Externí odkaz:
https://doaj.org/article/4d00584fa22b4334a2ea2e93bb9f451b
Autor:
Pradeep Kumar Prabhakar, Jose Henrique Pereira, Rahil Taujale, Wanchen Shao, Vivek S. Bharadwaj, Digantkumar Chapla, Jeong-Yeh Yang, Yannick J. Bomble, Kelley W. Moremen, Natarajan Kannan, Michal Hammel, Paul D. Adams, Henrik V. Scheller, Breeanna R. Urbanowicz
Publikováno v:
Nature plants, vol 9, iss 3
Nat Plants
Nat Plants
Rhamnogalacturonan I (RGI) is a structurally complex pectic polysaccharide with a backbone of alternating rhamnose and galacturonic acid residues substituted with arabinan and galactan side chains. Galactan synthase 1 (GalS1) transfers galactose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cad97d286bc8006aca3f704a174a49f
https://escholarship.org/uc/item/8qn0t87z
https://escholarship.org/uc/item/8qn0t87z
Autor:
Wayland Yeung, Zhongliang Zhou, Liju Mathew, Nathan Gravel, Rahil Taujale, Brady O’Boyle, Mariah Salcedo, Aarya Venkat, William Lanzilotta, Sheng Li, Natarajan Kannan
Publikováno v:
Briefings in Bioinformatics. 24
Protein language models, trained on millions of biologically observed sequences, generate feature-rich numerical representations of protein sequences. These representations, called sequence embeddings, can infer structure-functional properties, despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c170ccd3a79c18f0c69b7a28b9d34e41
https://doi.org/10.1093/bib/bbac619
https://doi.org/10.1093/bib/bbac619
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Glycosyltransferases (GTs) play fundamental roles in nearly all cellular processes through the biosynthesis of complex carbohydrates and glycosylation of diverse protein and small molecule substrates. The extensive structural and functional diversifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98fd6a55db93299c6e441e775e3c3b7
https://doaj.org/article/f5c17c58d05e4400857aec9c85fdb18c
https://doaj.org/article/f5c17c58d05e4400857aec9c85fdb18c