Genome-wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical Progression

Autor: Tobias Hallén, Gudmundur Johannsson, Rahil Dahlén, Camilla A M Glad, Charlotte Örndal, Angelica Engvall, Helena Carén, Thomas Skoglund, Daniel S Olsson

Publikováno v: The Journal of clinical endocrinology and metabolism. 107(8)

Context Tumor progression in surgically treated patients with nonfunctioning pituitary adenomas (NFPAs) is associated with excess mortality. Reliable biomarkers allowing early identification of tumor progression are missing. Objective To explore DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107ffc89a75d10613d838637910aaf52
https://pubmed.ncbi.nlm.nih.gov/35485764

Fluid‐based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases

Autor: Kaj Blennow, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Ann Brinkmalm, Rahil Dahlén, Erik Portelius, Johan Gobom

Publikováno v: Journal of Neurochemistry. 151:417-434

Neurodegenerative dementias constitute a broad group of diseases in which abnormally folded proteins accumulate in specific brain regions and result in tissue reactions that eventually cause neuronal dysfunction and degeneration. Depending on where i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091056b32bcba1b6af5d193cf5b254d1
https://doi.org/10.1111/jnc.14594

Genome-Wide DNA Methylation Differences in Patients With Non-Functioning Pituitary Adenomas With or Without Postsurgical Intervention

Autor: Gudmundur Johannsson, Tobias Hallén, Rahil Dahlén, Charlotte Örndal, Helena Carén, Camilla A M Glad, Angelica Engvall, Thomas Skoglund, Johanna C. Andersson-Assarsson, Daniel S Olsson

Publikováno v: Journal of the Endocrine Society

Background: More than half of all surgically treated patients with non-functioning pituitary adenomas (NFPA) experience tumor progression during their follow-up, with some of these adenomas exhibiting locally aggressive behavior. Tumor progression is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fd1a7962e9070bccece5f3ea75e9e9
http://europepmc.org/articles/PMC8090575

A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer's disease

Autor: Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, Wiesje van der Flier, Philip Scheltens, Floor Duits, Oskar Hansson, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom

Publikováno v: Scientific Reports, 7(1):13333. Nature Publishing Group
Scientific Reports
Skillbäck, T, Mattsson, N, Hansson, K, Mirgorodskaya, E, Dahlén, R, Van Der Flier, W, Scheltens, P, Duits, F, Hansson, O, Teunissen, C, Blennow, K, Zetterberg, H & Gobom, J 2017, ' A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer's disease ', Scientific Reports, vol. 7, no. 1, 13333 . https://doi.org/10.1038/s41598-017-13831-0
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

We present a new, quantification-driven proteomic approach to identifying biomarkers. In contrast to the identification-driven approach, limited in scope to peptides that are identified by database searching in the first step, all MS data are conside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94b6e2811014ddc5f765217ac9484243
https://research.vumc.nl/en/publications/9f92bf5a-c830-4421-a797-9c5947bb54cb

Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cellsin vitrofrom Patients with Clinically Active Ulcerative Colitis

Autor: Henrik Sjövall, Anna Lundgren, Magnus Simren, Stefan Isaksson, Rahil Dahlén, Sukanya Raghavan, Maria K. Magnusson, Lena Öhman, Hilja Strid

Publikováno v: Scandinavian Journal of Immunology. 78:275-284

Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3a304396227c93c08edb1fcebe2715
https://doi.org/10.1111/sji.12081