Cephalopod-inspired jetting devices for gastrointestinal drug delivery.

Autor: Arrick G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Sticker D; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Ghazal A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Lu Y; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Duncombe T; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Gwynne D; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Mouridsen B; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Wainer J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jepsen JPH; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Last TS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Schultz D; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Hess K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Medina De Alba E; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Min S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Poulsen M; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Anker C; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Karandikar P; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Pedersen HD; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Collins J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Egecioglu NE; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Tamang S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cleveland C; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Ishida K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Uhrenfeldt AH; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Kuosmanen J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Pereverzina M; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Hayward A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kirk RK; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., You S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dalsgaard CM; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Gunnarsson SB; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Patsi I; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Bohr A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Azzarello A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Frederiksen MR; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Herskind P; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Li J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Roxhed N; Micro and Nanosystems, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden., Rahbek UL; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Water JJ; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Buckley ST; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark. spby@novonordisk.com., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. cgt20@mit.edu.

Publikováno v: Nature [Nature] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies.

Autor: Tan HY; Technical University of Denmark, Department of Micro and Nanotechnology, Ørsteds Plads, Lyngby, Denmark.; Technical University of Denmark, Center for Nanomedicine and Theranostics, Ørsteds Plads, Lyngby, Denmark.; Biomedical Institute for Global Health Research & Technology (BIGHEART), National University of Singapore, Singapore., Trier S; Global Research, Novo Nordisk A/S, Maaloev, Denmark., Rahbek UL; Global Research, Novo Nordisk A/S, Maaloev, Denmark., Dufva M; Technical University of Denmark, Department of Micro and Nanotechnology, Ørsteds Plads, Lyngby, Denmark., Kutter JP; Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark., Andresen TL; Technical University of Denmark, Department of Micro and Nanotechnology, Ørsteds Plads, Lyngby, Denmark.; Technical University of Denmark, Center for Nanomedicine and Theranostics, Ørsteds Plads, Lyngby, Denmark.

Publikováno v: PloS one [PLoS One] 2018 May 10; Vol. 13 (5), pp. e0197101. Date of Electronic Publication: 2018 May 10 (Print Publication: 2018).

Applicability and Limitations of Cell-Penetrating Peptides in Noncovalent Mucosal Drug or Carrier Delivery Systems.

Autor: Kamei N; Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586, Japan., Bech Nielsen EJ; Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586, Japan; Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark; Novozymes A/S, DK-2880 Bagsvaerd, Denmark., Nakakubo T; Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586, Japan., Aoyama Y; Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586, Japan., Rahbek UL; Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark., Pedersen BL; Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark., Takeda-Morishita M; Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Hyogo 650-8586, Japan. Electronic address: mmtakeda@pharm.kobegakuin.ac.jp.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2016 Feb; Vol. 105 (2), pp. 747-753.

Acylation of Glucagon-like peptide-2: interaction with lipid membranes and in vitro intestinal permeability.

Autor: Trier S; Dept. of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Kgs. Lyngby, Denmark; Diabetes Research Unit, Novo Nordisk, Maaloev, Denmark., Linderoth L; Diabetes Research Unit, Novo Nordisk, Maaloev, Denmark., Bjerregaard S; Diabetes Research Unit, Novo Nordisk, Maaloev, Denmark., Andresen TL; Dept. of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Kgs. Lyngby, Denmark., Rahbek UL; Diabetes Research Unit, Novo Nordisk, Maaloev, Denmark.

Publikováno v: PloS one [PLoS One] 2014 Oct 08; Vol. 9 (10), pp. e109939. Date of Electronic Publication: 2014 Oct 08 (Print Publication: 2014).

The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition.

Autor: Welling SH; Diabetes Research Unit, Novo Nordisk A/S, Måløv, Denmark; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hubálek F; Diabetes Research Unit, Novo Nordisk A/S, Måløv, Denmark., Jacobsen J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brayden DJ; UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Dublin, Ireland., Rahbek UL; Diabetes Research Unit, Novo Nordisk A/S, Måløv, Denmark., Buckley ST; Diabetes Research Unit, Novo Nordisk A/S, Måløv, Denmark. Electronic address: spby@novonordisk.com.

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2014 Apr; Vol. 86 (3), pp. 544-51. Date of Electronic Publication: 2013 Dec 31.