Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rahasson R. Ager"'
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Antonia Gutierrez, Rahasson R. Ager, Angela Gomez-Arboledas, Amanda McQuade, Carlos J. Rodriguez-Ortiz, Jose Carlos Davila, Jimmy Phan, Mathew Blurton-Jones, Stefania Forner, Celia da Cunha, Masashi Kitazawa, Laura Trujillo-Estrada, Melanie Tram, David Baglietto-Vargas, Alessandra C. Martini, Jordan-Vu Ha, Dominic I. Javonillo, Emma Danhash, Rodrigo Medeiros, Frank M. LaFerla
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses, and the chronic inflammation mediated by inflammatory receptors represents a key mechanism by which amyloid-beta (Aβ) dr
Autor:
Elizabeth J. Andrews, Pedro E. Cruz, Rahasson R. Ager, Laura Trujillo-Estrada, David Baglietto-Vargas, Jordan Vu Ha, Alessandra C. Martini, Cindy T. Dang, Todd E. Golde, Carl W. Cotman, Jorge Mauricio Reyes-Ruiz, Masashi Kitazawa, Stefania Forner, Celia da Cunha, Charles G. Glabe, Allissa Vivienne Zhen Dur Chang, Carlos J. Rodriguez-Ortiz, Jimmy Phan, Frank M. LaFerla, Yona Levites, Rodrigo Medeiros, G. Aleph Prieto
Publikováno v:
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with dementia severity when com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88393a95fcbf60ef9f0462d29f57ff2
https://escholarship.org/uc/item/8000q2s0
https://escholarship.org/uc/item/8000q2s0
Autor:
Celia da Cunha, Rahasson R. Ager, Gilberto Aleph Prieto, Stefania Forner, Cassidy Nguyen, Laura Trujillo-Estrada, Carl W. Cotman, Alessandra C. Martini, Lena Cai, David Baglietto-Vargas, Frank M. LaFerla
Publikováno v:
Aging cell, vol 18, iss 3
Aging Cell
Aging Cell
Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab29c2fd175b88642113f54db363ba7e
https://escholarship.org/uc/item/59h4s1h8
https://escholarship.org/uc/item/59h4s1h8
Publikováno v:
Neuroscience & Biobehavioral Reviews. 64:272-287
Despite intensive research efforts over the past few decades, the mechanisms underlying the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major concern because the number of patients affected by this medical condition
Autor:
Alessandra C. Martini, Kristine Minh Tran, Kelly Do Huynh, Cristina Nuñez-Diaz, Franklin Garcia, Celia da Cunha, Kim N. Green, Andrea J. Tenner, Rahasson R. Ager, Stefania Forner, David Baglietto-Vargas, Dina P. Matheos, Marcelo A. Wood, Carlos J. Rodriguez-Ortiz, Laura Trujillo-Estrada, Frank M. LaFerla, Enikö A. Kramár, Jimmy Phan, Xinyi Ma, Claudio Soto, Ines Moreno-Gonzalez, Grant R. MacGregor, Vivek Swarup, Juan Antonio García-León, Lena Cai, Masashi Kitazawa, Dominic I. Javonillo, Mohammad Shahnawaz, Jessica E. Childs, Antonia Gutierrez, Ali Mortazavi, Shan Jiang, Marie Minh Thu Nguyen, Gabriela Balderrama-Gutierrez, Ken C. Walls
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. H
The incidence and prevalence of neurodegenerative disorders (e.g., Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), etc.) are growing rapidly due to increasing life expectancy. Researchers over the past two dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5992b4066fd30f9c73f1f5c63c22350e
https://doi.org/10.1093/med/9780190233563.003.0014
https://doi.org/10.1093/med/9780190233563.003.0014
Autor:
Frank M. LaFerla, Alessandra C. Martini, Masashi Kitazawa, Carlos J. Rodriguez-Ortiz, Laura Trujillo-Estrada, Jose Carlos Davila, Antonia Gutierrez, Rodrigo Medeiros, Kenji Ikemura, David Baglietto-Vargas, Agenor Limon, Gilberto Aleph Prieto, Carl W. Cotman, Rahasson R. Ager, Stefania Forner
Publikováno v:
Aging cell, vol 17, iss 4
Aging Cell
Aging Cell
Summary Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular
Autor:
Stephen M. Taylor, Maria I. Fonseca, Sam D. Sanderson, Shu Hui Chu, Trent M. Woodruff, Andrea J. Tenner, Rahasson R. Ager
Publikováno v:
Journal of Neurochemistry. 113:389-401
Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by the accumulation of amyloid-beta protein and neuronal loss, is the leading cause of age-related dementia in the world today. The disease is also associated with neuroi
Autor:
Maria I. Fonseca, Sam D. Sanderson, Trent M. Woodruff, Frank M. LaFerla, Ozkan Yazan, Shu Hui Chu, Rahasson R. Ager, Andrea J. Tenner, Stephen M. Taylor
Publikováno v:
The Journal of Immunology
Alzheimer’s disease (AD) is an age-related dementia, characterized by amyloid plaques, neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of the complement system, known to produce a local inflammatory reaction,