Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals.

Autor: Brüggemann RJ; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands., Moes DJAR; Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands. Electronic address: d.j.a.r.moes@lumc.nl., van Rhee KP; Tergooi Hospital, Department of Clinical Pharmacy, Hilversum, The Netherlands. Electronic address: kvanrhee@tergooi.nl., van 't Veer NE; Department of Clinical Pharmacy, Amphia hospital, Breda, The Netherlands. Electronic address: 0000-0003-1312-8495NvtVeer@amphia.nl., Koch BCP; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: b.c.p.koch@erasmusmc.nl., van Rossum M; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: mara.vanrossum@radboudumc.nl., Windsant-van den Tweel AV; Jeroen Bosch Hospital, Department of Pharmacy, 's Hertogenbosch, The Netherlands. Electronic address: A.Vermeulenwindsant@jbz.nl., Reijers MHE; Radboud University Medical Center, Department of Pulmonary Diseases, Nijmegen, The Netherlands. Electronic address: Monique.Reijers@radboudumc.nl., van Kimmenade RRJ; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Roland.vanKimmenade@radboudumc.nl., Rahamat-Langedoen JC; Radboud Institute for Molecular Life Sciences, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Janette.Rahamat-Langedoen@radboudumc.nl., Rettig TCD; Department of Intensive Care and Pain Medicine, Amphia hospital, Breda, The Netherlands. Electronic address: Trettig@amphia.nl., van Raalte R; Department of Intensive Care, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: RvanRaalte@tergooi.nl., van Paassen J; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: J.van_Paassen@lumc.nl., Polderman FN; Jeroen Bosch Hospital, Department of Intensive Care, 's Hertogenbosch, The Netherlands. Electronic address: f.polderman@jbz.nl., van der Linden PD; Department of Clinical Pharmacy, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: pvanderlinden@tergooi.nl., Frenzel T; Radboud university medical center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: Tim.Frenzel@radboudumc.nl., de Mast Q; Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: Quirijn.deMast@radboudumc.nl., Burger DM; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: David.Burger@radboudumc.nl., Schouten J; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: Jeroen.schouten@radboudumc.nl., van de Veerdonk FL; Department of Internal Medicine, Radboudumc, Nijmegen, The Netherlands. Electronic address: 0000-0002-1121-4894Frank.vandeVeerdonk@radboudumc.nl., Pickkers P; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: peter.pickkers@radboudumc.nl., Ter Heine R; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: R.terHeine@radboudumc.nl.

Publikováno v: International journal of antimicrobial agents [Int J Antimicrob Agents] 2021 Mar; Vol. 57 (3), pp. 106293. Date of Electronic Publication: 2021 Jan 27.