Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ragu Kanagasabai"'
Autor:
W. David Nes, Mathew B. Miller, Phani Veeramachanemi, Archana Sinha, Pruthvi Jayasimha, Jialin Liu, Ragu Kanagasabai, Zhihong Song, Wenxu Zhou
Publikováno v:
Molecules, Vol 9, Iss 4, Pp 185-203 (2004)
Current progress on the mechanism and substrate recognition by sterol methyl transferase (SMT), the role of mechanism-based inactivators, other inhibitors of SMT action to probe catalysis and phytosterol synthesis is reported. SMT is a membrane-bound
Externí odkaz:
https://doaj.org/article/c514f08e6352436481d3128658bd0518
Autor:
Soumendrakrishna Karmahapatra, Corey A. Kientz, Terry S. Elton, Jack C. Yalowich, Ragu Kanagasabai, Evan E. Kania, Yang Yu, Victor A. Hernandez
Publikováno v:
Molecular Pharmacology. 93:515-525
DNA topoisomerase IIα (170 kDa, TOP2α/170) is essential in proliferating cells by resolving DNA topological entanglements during chromosome condensation, replication, and segregation. We previously characterized a C-terminally truncated isoform (TO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f9061b001afb086d6685dc415f5ea8
https://doi.org/10.1124/mol.117.111567
https://doi.org/10.1124/mol.117.111567
Autor:
Soumendrakrishna Karmahapatra, Justin Ellis, Ragu Kanagasabai, Terry S. Elton, Mary K. Ritke, Lucas Serdar, Corey A. Kientz, Jack C. Yalowich
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:152-163
DNA topoisomerase IIα (TOP2α) is a prominent target for anticancer drugs whose clinical efficacy is often limited by chemoresistance. Using antibody specific for the N-terminal of TOP2α, immunoassays indicated the existence of two TOP2α isoforms,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209b69f4129e6e4b7e0f819218acf6be
https://doi.org/10.1124/jpet.116.237107
https://doi.org/10.1124/jpet.116.237107
Autor:
Xiaoli Zhao, Jack C. Yalowich, Rolf D. Hubmayr, Richard A. Oeckler, Hiroshi Takeshima, Konstantin Shilo, Nagaraja N. Nagre, Ragu Kanagasabai, Jing Deng, John W. Christman, Miyuki Nishi, Thomas Kellett, Shaohua Wang
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 310:L452-L464
Alveolar epithelial and endothelial cell injury is a major feature of the acute respiratory distress syndrome, in particular when in conjunction with ventilation therapies. Previously we showed [Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2158a2ee6e9c881a93d510f8c12ad46a
https://doi.org/10.1152/ajplung.00089.2015
https://doi.org/10.1152/ajplung.00089.2015
Autor:
Daywin Patel, Soumendrakrishna Karmahapatra, Brian B. Hasinoff, Ragu Kanagasabai, Xing Wu, Jack C. Yalowich
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:397-409
Pixantrone is a new noncardiotoxic aza-anthracenedione anticancer drug structurally related to anthracyclines and anthracenediones, such as doxorubicin and mitoxantrone. Pixantrone is approved in the European Union for the treatment of relapsed or re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fabad1241f9ffcf0d4fed9efcd35d6b
https://doi.org/10.1124/jpet.115.228650
https://doi.org/10.1124/jpet.115.228650
Autor:
Ragu, Kanagasabai, Soumendrakrishna, Karmahapatra, Corey A, Kientz, Yang, Yu, Victor A, Hernandez, Evan E, Kania, Jack C, Yalowich, Terry S, Elton
Publikováno v:
Molecular pharmacology. 93(5)
DNA topoisomerase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::107f08bbd87b88a8dffd183ac5e04475
https://pubmed.ncbi.nlm.nih.gov/29514855
https://pubmed.ncbi.nlm.nih.gov/29514855
Autor:
Andrew C. Huntsman, Soumendrakrishna Karmahapatra, Alexandria N. Young, Joanna E. Burdette, Malcolm S. Cole, Hee Byung Chai, Denisse Herrera, Jack C. Yalowich, Yulin Ren, John L. Woodard, A. Douglas Kinghorn, James R. Fuchs, Ragu Kanagasabai, Pratiq A. Patel
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
A series of arylnaphthalene lignan lactones based on the structure of the phyllanthusmins, a class of potent natural products possessing diphyllin as the aglycone, has been synthesized and screened for activity against multiple cancer cell lines. SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9f76c953e57e920688fc03b3a998a9
https://pubmed.ncbi.nlm.nih.gov/29656990
https://pubmed.ncbi.nlm.nih.gov/29656990
Publikováno v:
Free Radical Biology and Medicine. 128:S67-S68
Heat shock factor-1 (HSF-1) is an important regulator of oncogenes, affecting both pathogenesis and prognosis of human cancer. However, it is not currently known how HSF-1 can modulate immune response in cancer progression. In the present work, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a55b1519a2cb2744920c204738541ed
https://doi.org/10.1016/j.freeradbiomed.2018.10.141
https://doi.org/10.1016/j.freeradbiomed.2018.10.141
Autor:
Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams
Publikováno v:
Cancer Research. 79:1233-1233
In cancer, suppression of host immunity is related, in part, to immature myeloid-derived suppressor cells (MDSCs) expanded in response to various tumor- or stroma-derived factors. Here, the expression and activity of myeloperoxidase (MPO) was examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3529927d46ddd9c91b112ca97093543d
https://doi.org/10.1158/1538-7445.am2019-1233
https://doi.org/10.1158/1538-7445.am2019-1233
Publikováno v:
Biochemical Pharmacology. 84:52-58
The thiosemicarbazones Dp44mT (di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone) and triapine have potent antiproliferative activity and have been evaluated as anticancer agents. While these compounds strongly bind iron and copper, their mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4c471e0d41425bc9a495e9216fb048
https://doi.org/10.1016/j.bcp.2012.03.021
https://doi.org/10.1016/j.bcp.2012.03.021