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Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Ab Oligomerization in Vitro and Ab Oligomer-Mediated Memory Impairment

Autor: Tomaselli S., La Vitola P., Pagano K., Brandi E., Santamaria G., Galante D., D'Arrigo C., Moni L., Lambruschini C., Banfi L., Lucchetti J., Fracasso C., Molinari H., Forloni G., Balducci C., Ragona L.

Publikováno v: ACS chemical neuroscience 10 (2019): 4462–4475. doi:10.1021/acschemneuro.9b00241
info:cnr-pdr/source/autori:Tomaselli S.; La Vitola P.; Pagano K.; Brandi E.; Santamaria G.; Galante D.; D'Arrigo C.; Moni L.; Lambruschini C.; Banfi L.; Lucchetti J.; Fracasso C.; Molinari H.; Forloni G.; Balducci C.; Ragona L./titolo:Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Ab Oligomerization in Vitro and Ab Oligomer-Mediated Memory Impairment/doi:10.1021%2Facschemneuro.9b00241/rivista:ACS chemical neuroscience/anno:2019/pagina_da:4462/pagina_a:4475/intervallo_pagine:4462–4475/volume:10

In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of A? oligomers, the most toxic species causing synaptic dysfunction, neuroinflammation, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::adda30b6f0181dd349fdbd161a1afa89
https://publications.cnr.it/doc/414274

Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors: AN INTEGRATED STRATEGY FOR THE DEVELOPMENT OF NEW ANTIANGIOGENIC COMPOUNDS*

Autor: Colombo G., Margosio B., Ragona L., Neves M., Bonifacio S., Annis D.S., Stravalaci M., Tomaselli S., Giavazzi R., Rusnati M., Presta M., Zetta L., Mosher D.F., Ribatti D., Gobbi M., Taraboletti G.

Publikováno v: Journal of Biological Chemistry; Vol 285
The Journal of biological chemistry
285 (2010): 8733–8742. doi:10.1074/jbc.M109.085605
info:cnr-pdr/source/autori:Colombo G.; Margosio B.; Ragona L.; Neves M.; Bonifacio S.; Annis D.S.; Stravalaci M.; Tomaselli S.; Giavazzi R.; Rusnati M.; Presta M.; Zetta L.; Mosher D.F.; Ribatti D.; Gobbi M.; Taraboletti G./titolo:Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors. An integrated strategy for the development of new antiangiogenic compounds/doi:10.1074%2Fjbc.M109.085605/rivista:The Journal of biological chemistry (Print)/anno:2010/pagina_da:8733/pagina_a:8742/intervallo_pagine:8733–8742/volume:285

Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat angiogenesis-driven diseases, including cancer. TSP-1 regulates angiogenesis through different mechanisms, including binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64d839b45d66ba6390a126baa60797a6

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