Genetics of gene expression and its effect on disease

Autor: Sonia Carlson, Steinunn Gunnarsdottir, Jeffrey R. Gulcher, Gyda Bjornsdottir, Marc L. Reitman, Valgerdur Steinthorsdottir, Daniel F. Gudbjartsson, Amy Leonardson, Hjörtur Gislason, Unnur Styrkarsdottir, Augustine Kong, Ragnheidur Fossdal, John Lamb, Inga Reynisdottir, Gudrun H. Eiriksdottir, Kristleifur Kristjansson, Valur Emilsson, Jun Zhu, Kristinn P. Magnusson, Björn Geir Leifsson, Aslaug Jonasdottir, Agnar Helgason, Anna Helgadottir, Eric E. Schadt, Solveig Gretarsdottir, Magali Mouy, Kari Stefansson, Hreinn Stefansson, Gudmar Thorleifsson, Florian Zink, Bin Zhang, G. Bragi Walters, Tryggvi Stefansson, Adalbjorg Jonasdottir, Unnur Thorsteinsdottir

Publikováno v: Nature. 452:423-428

Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b412e71fe3672d58f4d547ba9b2cc4
https://doi.org/10.1038/nature06758

A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease

Autor: Efrosini Setakis, Ricardo Palacios, David Otaegui, Pablo Villoslada, Ragnheidur Fossdal, Manuel Comabella, Aslaug Jonasdottir, Jordi Pérez-Tur, Kjartan Benediktsson, Arcadi Navarro, Stephen Sawcer, Xavier Montalban, Alastair Compston, Adolfo López de Munain, Emilio G. de la Concha, Robert Goertsches, Rafael Arroyo

Publikováno v: Journal of Neuroimmunology. 143:124-128

In order to identify the genomic regions that might confer susceptibility to multiple sclerosis (MS) in the Spanish population, we have performed a genome-wide screen for association in patients with MS using pooled DNA from 200 clinical cases and 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e573d8c21436a0b5b4bdd3bccc06760c
https://doi.org/10.1016/j.jneuroim.2003.08.026

Expanding the range of ZNF804A variants conferring risk of psychosis

Autor: Robin M. Murray, Vera Golimbet, Sven Cichon, M. Rietschel, D St Clair, Andres Ingason, Thomas Hansen, Sarah Tosato, Ole Mors, Omar Gustafsson, Ragnheidur Fossdal, J. Yoon, Olli Pietiläinen, Annette M. Hartmann, Augustine Kong, Lavinia Athanasiu, Unnur Thorsteinsdottir, Srdjan Djurovic, Tao Li, Elvira Bramon, Markus M. Nöthen, Dan Rujescu, Erik G. Jönsson, Leena Peltonen, Jan-Erik Lönnqvist, Mette Nyegaard, Annamari Tuulio-Henriksson, Hannes Petursson, Birte Glenthøj, János Réthelyi, Nelson B. Freimer, Ingrid Melle, David M. Hougaard, M. Mattheisen, Lilia I. Abramova, Stacy Steinberg, Preben Bo Mortensen, David A. Collier, Ingrid Agartz, Neil Walker, Lambertus A. Kiemeney, H.-J. Möller, Gillian Fraser, Hreinn Stefansson, Ina Giegling, Anders D. Børglum, René Breuer, Thorgeir E. Thorgeirsson, Evangelos Vassos, Gesche Jürgens, Thomas Werge, Iris H Gudjonsdottir, Pall I. Olason, Lars Terenius, Kari Stefansson, Thordur Sigmundsson, Merete Nordentoft, Yvonne Böttcher, Bent Nørgaard-Pedersen, Tiina Paunio, Rita M. Cantor, Roel A. Ophoff, Henrik B. Rasmussen, Kaleda Vg, István Bitter, Jaana Suvisaari, Timothea Toulopoulou, Mirella Ruggeri, Eric Strengman, Engilbert Sigurdsson, Muriel Walshe, Ole A. Andreassen

Publikováno v: Steinberg, S, Mors, O, Børglum, A D, Gustafsson, O, Werge, T, Mortensen, P B, Andreassen, O A, Sigurdsson, E, Thorgeirsson, T E, Böttcher, Y, Olason, P, Ophoff, R A, Cichon, S, Gudjonsdottir, I H, Pietiläinen, O P H, Nyegaard, M, Tuulio-Henriksson, A, Ingason, A, Hansen, T, Athanasiu, L, Suvisaari, J, Lonnqvist, J, Paunio, T, Hartmann, A, Jürgens, G, Nordentoft, M, Hougaard, D, Norgaard-Pedersen, B, Breuer, R, Möller, H-J, Giegling, I, Glenthøj, A B, Rasmussen, H B, Mattheisen, M, Bitter, I, Réthelyi, J M, Sigmundsson, T, Fossdal, R, Thorsteinsdottir, U, Ruggeri, M, Tosato, S, Strengman, E, Kiemeney, L A, Melle, I, Djurovic, S, Abramova, L, Kaleda, V, Walshe, M, Bramon, E, Vassos, E & Genetic Risk and Outcome in Psychosis 2011, ' Expanding the range of ZNF804A variants conferring risk of psychosis ', Molecular Psychiatry, vol. 16, no. 1, pp. 59-66 . https://doi.org/10.1038/mp.2009.149
Molecular Psychiatry; Vol 16
Molecular Psychiatry, 16, 59-66
Steinberg, S, Mors, O, Borglum, AD, Gustafsson, O, Werge, T, Mortensen, P B, Andreassen, O A, Sigurdsson, E, Thorgeirsson, T E, Bottcher, Y, Olason, P, Ophoff, R A, Cichon, S, Gudjonsdottir, I H, Pietilainen, O P, Nyegaard, M, Tuulio-Henriksson, A, Ingason, A, Hansen, T, Athanasiu, L, Suvisaari, J, Lonnqvist, J, Paunio, T, Hartmann, A, Jurgens, G, Nordentoft, M, Hougaard, D, Norgaard-Pedersen, B, Breuer, R, Moller, H J, Giegling, I, Glenthoj, B, Rasmussen, H B, Mattheisen, M, Bitter, I, Rethelyi, J M, Sigmundsson, T, Fossdal, R, Thorsteinsdottir, U, Ruggeri, M, Tosato, S, Strengman, E, Bruggeman, R, Cahn, W, de Haan, L, Kahn, R, Krabbendam, L, Linzen, D, Myin-Germeys, I, van Os, J, Wiersma, D, Kiemeney, L A, Melle, I, Djurovic, S, Abramova, L, Kaleda, V, Walshe, M, Bramon, E, Vassos, E, Li, T, Fraser, G, Walker, N, Toulopoulou, T, Yoon, J, Freimer, N B, Cantor, R M, Murray, R, Kong, A, Golimbet, V, Jonsson, E G, Terenius, L, Agartz, I, Petursson, H, Nothen, M M, Rietschel, M, Peltonen, L, Rujescu, D, Collier, D A, Stefansson, H, Clair, D & Stefansson, K 2011, ' Expanding the range of ZNF804A variants conferring risk of psychosis ', Molecular Psychiatry, vol. 16, pp. 59-66 . https://doi.org/10.1038/mp.2009.149
Molecular Psychiatry
Molecular Psychiatry, 16, 59-66. Nature Publishing Group
Molecular Psychiatry, 16(1), 59-66. Nature Publishing Group
Molecular psychiatry 16, 59-66 (2011). doi:10.1038/mp.2009.149
Molecular Psychiatry, 16, 1, pp. 59-66
Molecular psychiatry, 16(1), 59-66. Nature Publishing Group

A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b708cd82bea3333a2a518ac6fe89366
https://pure.au.dk/portal/da/publications/expanding-the-range-of-znf804a-variants-conferring-risk-of-psychosis(c0b388f9-9f83-42c4-ace6-fc1471cc05e4).html

A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers

Autor: H. Jonsson, Stephen Sawcer, Ragnheidur Fossdal, Alastair Compston, Helga Einarsdottir, Kari Stefansson, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Theodora Thorlacius, Jesus Sainz, John Benedikz, Gudlaug Thora Kristjansdottir, Kjartan Benediktsson, Sonja Sigurdardottir, Jeffrey R. Gulcher

Publikováno v: Journal of neuroimmunology. 143(1-2)

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991c39bd5be644ea8aa8b688f8d69a91
https://pubmed.ncbi.nlm.nih.gov/14575921

A whole genome association study in multiple sclerosis patients from north Portugal

Autor: Paulo Costa, Isabel Leite, Theodora Thorlacius, J. Cerqueira, Berta Martins da Silva, Ragnheidur Fossdal, H. Jonsson, Thomas Foltynie, Stephen Sawcer, Clara Pereira, Alastair Compston, Aslaug Jonasdottir, Ana Martins da Silva, Monica Marta, Kjartan Benediktsson

Publikováno v: Journal of neuroimmunology. 143(1-2)

Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48aadf63b1f043c5910279d77720a956
https://pubmed.ncbi.nlm.nih.gov/14575927