A Randomized Controlled Trial on Safety of Steroid Avoidance in Immunologically Low-Risk Kidney Transplant Recipients

Autor: Jana Ekberg, Seema Baid-Agrawal, Bente Jespersen, Ragnar Källén, Ehab Rafael, Karin Skov, Per Lindnér

Publikováno v: Kidney International Reports, Vol 7, Iss 2, Pp 259-269 (2022)

Introduction: Steroid-based immunosuppression after transplantation increases the risk of post-transplant diabetes mellitus (PTDM), with adverse effects on patient and graft survival. In the SAILOR study, we investigated the safety and efficacy of co

Externí odkaz: https://doaj.org/article/1073c313e6c24da3aabdc331dad89be5

Tissue Factor Produced by the Endocrine Cells of the Islets of Langerhans Is Associated With a Negative Outcome of Clinical Islet Transplantation

Autor: Graciela Elgue, Helena Johansson, Lisa Moberg, Kristina Nilsson Ekdahl, Annika Tibell, Torbjörn Lundgren, Aksel Foss, Bo Nilsson, Kaija Salmela, C Berne, Ragnar Källén, Agneta Lukinius, Marie Felldin, Gunnar Tufveson, Olle Korsgren

Publikováno v: Diabetes. 54:1755-1762

There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42df6485b9e027afd78a27feaee17ad3
https://doi.org/10.2337/diabetes.54.6.1755

Two Doses of Daclizumab in Conjunction with Low-Dose Cyclosporine, Mycophenolate Mofetil and Steroids Resulted in a Low Incidence of Acute Rejection after Renal Transplantation

Autor: Ragnar Källén, Henrik Ekberg, Persson Nh, N Gül-Baykurt

Publikováno v: Scandinavian Journal of Immunology. 58:670-677

Five doses of daclizumab, given initially after kidney transplantation, reduce the rate of acute rejection (AR). Without cyclosporin A (CsA), a protocol, including daclizumab, mycophenolate mofetil (MMF) and corticosteroids (CSs), has recently shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21f5395dbbfa2da054b1edb578f36e5
https://doi.org/10.1111/j.1365-3083.2003.01345.x

Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation

Autor: Ø Østraat, Helena Johansson, Aksel Foss, Graciela Elgue, Olle Korsgren, Bo Nilsson, K Nilsson Ekdahl, Annika Tibell, Gunnar Tufveson, Agneta Lukinius, Ragnar Källén, C Berne, Lisa Moberg, Kaija Salmela

Publikováno v: The Lancet. 360:2039-2045

Intraportal transplantation of pancreatic islets offers improved glycaemic control and insulin independence in type 1 diabetes mellitus, but intraportal thrombosis remains a possible complication. The thrombotic reaction may explain why graft loss oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11fd5d91b2e371a852f1c5ba72b4b70
https://doi.org/10.1016/s0140-6736(02)12020-4

An in-progress, open-label, multi-centre study (SAILOR) evaluating whether a steroid-free immunosuppressive protocol, based on ATG induction and a low tacrolimus dose, reduces the incidence of new onset diabetes after transplantation

Autor: Ragnar Källén, Jana Ekberg, Karin Skov, Lars Mjörnstedt, Bente Jespersen, Michael Olausson, Per Lindnér, Henrik Ekberg

Publikováno v: Transplantation Research
Ekberg, J, Ekberg, H, Jespersen, B, Källen, R, Skov, K, Olausson, M, Mjörnstedt, L & Lindnér, P 2014, ' An in-progress, open-label, multi-centre study (SAILOR) evaluating whether a steroid-free immunosuppressive protocol, based on ATG induction and a low tacrolimus dose, reduces the incidence of new onset diabetes after transplantation ', Transplantation Research, vol. 3, pp. 12 . https://doi.org/10.1186/2047-1440-3-12

BACKGROUND: Corticosteroids and calcineurin inhibitors (CNIs) are included in renal transplantation immunosuppressive protocols around the world. Well-known side effects are associated with the use of these drugs, including new onset of diabetes afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82b243423ede0fc2ede9f692614ef90
https://pubmed.ncbi.nlm.nih.gov/24959347