MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Autor: Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert, Michael Boutros

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently in

Externí odkaz: https://doaj.org/article/54b4ea38523f4011a819f580a23a3c55

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling

Autor: Ragna S. Häussler, Björn Forsström, Annika Bendes, Mathias Uhlén, Göran Bergström, Patrik K. E. Magnusson, Cecilia Engel Thomas, Mun-Gwan Hong, Fredrik Edfors, Linn Fagerberg, Tea Dodig-Crnković, Ina Schuppe-Koistinen, Matilda Dale, Jochen M. Schwenk, Jacob Odeberg, Anders Gummesson

Publikováno v: Dodig-Crnković, T, Hong, M G, Thomas, C E, Häussler, R S, Bendes, A, Dale, M, Edfors, F, Forsström, B, Magnusson, P K E, Schuppe-Koistinen, I, Odeberg, J, Fagerberg, L, Gummesson, A, Bergström, G, Uhlén, M & Schwenk, J M 2020, ' Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling ', EBioMedicine, vol. 57, 102854 . https://doi.org/10.1016/j.ebiom.2020.102854
EBioMedicine
EBioMedicine, Vol 57, Iss, Pp 102854-(2020)

BackgroundPrecision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d2192d3cea12386c7dbf6af8ff8920
https://hdl.handle.net/10037/24818

Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

Autor: Femke Rutters, Naeimeh Atabaki-Pasdar, Donna McEvoy, Helle Krogh Pedersen, Jerzy Adamski, Torben Hansen, Gary Frost, François Pattou, Hartmut Ruetten, Gwen Kennedy, Emmanouil T. Dermitzakis, Ana Viñuela, Federico De Masi, Robert W. Koivula, Hugo Pomares-Millan, Henrik S. Thomsen, Alison Heggie, Jochen M. Schwenk, Ragna S. Häussler, Sapna Sharma, Cecilia Engel Thomas, Mun-Gwan Hong, Joline W.J. Beulens, Anubha Mahajan, Petra J. M. Elders, Imre Pavo, Mark Walker, Juan P. Fernandez, Ian M Forgie, Timothy J. McDonald, Mattias Ohlsson, Hugo Fitipaldi, Adem Y. Dawed, Ramneek Gupta, Giuseppe N. Giordano, Søren Brunak, Mark Haid, Tarja Kokkola, Andrew T. Hattersley, Francesca Frau, Pascal M. Mutie, Martin Ridderstråle, Tue H. Hansen, Andrea Mari, Jagadish Vangipurapu, Elizaveta Chabanova, Henna Cederberg, Jimmy D. Bell, Azra Kurbasic, Henrik Vestergaard, Leen M 't Hart, Violeta Raverdy, Matilda Dale, Kristine H. Allin, Mark I. McCarthy, Angus G. Jones, E. Louise Thomas, Paul W. Franks, Markku Laakso, Petra B. Musholt, Soren Brage, Ewan R. Pearson, Oluf Pedersen

BackgroundNon-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0580d47b123af81513e6295d8ce068e1

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Autor: I Hinsenkamp, Gerrit Erdmann, Giulia Ambrosi, Bernd Hessling, Benedikt Rauscher, Matthias P. Ebert, Elke Burgermeister, Tianzuo Zhan, Leonhard Bamberg, Michael Boutros, Karin Müller-Decker, N Rindtorff, Anna Maxi Wandmacher, Johannes Betge, Ragna S. Häussler

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44770ed31e5c4bab2e41715f980527cf
https://doi.org/10.1055/s-0039-1695401

Systematic Development Of Sandwich Immunoassays For The Plasma Secretome

Autor: Ragna S. Häussler, Hanna Tegel, Claudia Fredolini, Elin Birgersson, Johan Rockberg, Fredrik Edfors, Matilda Dale, Maria Jesus Iglesias, Tea Dodig-Crnković, Sanna Byström, Linn Fagerberg, Jochen M. Schwenk, Ulrika Qundos, Mathias Uhlén, Annika Bendes, Laura Sanchez-Rivera

Publikováno v: Häussler, R S, Bendes, A, Iglesias, M J, Sanchez-Rivera, L, Dodig-Crnković, T, Byström, S, Fredolini, C, Birgersson, E, Dale, M, Edfors, F, Fagerberg, L, Rockberg, J, Tegel, H, Uhlén, M, Qundos, U & Schwenk, J M 2019, ' Systematic Development of Sandwich Immunoassays for the Plasma Secretome ', Proteomics, vol. 19, no. 15, 1900008 . https://doi.org/10.1002/pmic.201900008

The plasma proteome offers a clinically useful window into human health and disease. With recent progress made on the development of highly multiplexed immunoassays with high sample throughput, a remaining need is to establish a pipeline for validati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9149a8fc54097bbeff66c65619980d5