Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ragna Berthelsen"'
Autor:
Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Anders Kragh Hansen, Georgios A. Sotiriou, Korbinian Löbmann
Publikováno v:
Molecules, Vol 26, Iss 13, p 4035 (2021)
Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form. Upon exposure to laser radiation, elevated temperatures in the compacts are obtained. At temperatures above th
Externí odkaz:
https://doaj.org/article/521318070367416199aea4048ba9fa36
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 886 (2021)
Microwave-induced in situ amorphization of a drug into a polymeric amorphous solid dispersion (ASD) has been suggested to follow a dissolution process of the drug into the polymeric network, at temperatures above the glass transition temperature (Tg)
Externí odkaz:
https://doaj.org/article/f110e847334a4faa8bcfdc6e4a1f185b
Autor:
Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Georgios A. Sotiriou, Korbinian Löbmann
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 917 (2021)
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the infl
Externí odkaz:
https://doaj.org/article/44615c36a38d4452ac95afc63d8664d0
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 489 (2021)
The aim of this study was to design an in vitro lipolysis-permeation method to estimate drug absorption following the oral administration of self-nanoemulsifying drug delivery systems (SNEDDSs). The method was evaluated by testing five oral formulati
Externí odkaz:
https://doaj.org/article/4f35e77e011c475b9b155afa94efa8c2
Publikováno v:
Molecules, Vol 26, Iss 1, p 110 (2020)
Microwaved-induced in situ amorphization of a drug in a polymer has been suggested to follow a dissolution process, with the drug dissolving into the mobile polymer at temperatures above the glass transition temperature (Tg) of the polymer. Thus, bas
Externí odkaz:
https://doaj.org/article/bc650dede1834664ab08830ff86e0aaa
Publikováno v:
Molecules, Vol 25, Iss 5, p 1068 (2020)
The aim of the study was to investigate the suitability of a convection oven to induce in situ amorphization. The study was conducted using microwave radiation-induced in situ amorphization as reference, as it has recently been shown to enable the pr
Externí odkaz:
https://doaj.org/article/e3a5349923ed4cdb9a8531ccd267154f
Autor:
Mette Klitgaard, Maja Nørgaard Kristensen, Ramakrishnan Venkatasubramanian, Priscila Guerra, Jette Jacobsen, Ragna Berthelsen, Thomas Rades, Anette Müllertz
Publikováno v:
Drug Delivery and Translational Research. 13:1484-1499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04aa1f0c98424b217dbbaa5efb1338ac
https://doi.org/10.1007/s13346-023-01313-y
https://doi.org/10.1007/s13346-023-01313-y
Publikováno v:
Fredholt, F, Di Meo, C, Sloth, S, Müllertz, A & Berthelsen, R 2022, ' Direct visualizing of paracetamol immediate release tablet disintegration in vivo and in vitro ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 180, pp. 63-70 . https://doi.org/10.1016/j.ejpb.2022.09.007
The purpose of the present study was to study tablet disintegration by direct visualization, in vivo and in vitro. Based on literature data, a standard conventional paracetamol (CP) tablet, Panodil®, and a rapidly absorbed paracetamol (RP) tablet, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa159e21e892377fd3d0b5d5a43a9408
https://doi.org/10.1016/j.ejpb.2022.09.007
https://doi.org/10.1016/j.ejpb.2022.09.007
Autor:
Sofie Falkenløve Madsen, Ragna Berthelsen, Morten F. Ebbesen, Xiaolu Geng, Christine Heerup, Anette Müllertz
Publikováno v:
Heerup, C, Ebbesen, M F, Geng, X, Madsen, S F, Berthelsen, R & Müllertz, A 2021, ' Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion ', Food & Function, vol. 12, no. 7, pp. 2938-2949 . https://doi.org/10.1039/D0FO02976A
Heerup, C, Ebbesen, M F, Geng, X, Madsen, S F, Berthelsen, R & Müllertz, A 2021, ' Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion ', Food & Function, vol. 12, no. 7, pp. 2938-2949 . https://doi.org/10.1039/d0fo02976a
Heerup, C, Ebbesen, M F, Geng, X, Madsen, S F, Berthelsen, R & Müllertz, A 2021, ' Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion ', Food & Function, vol. 12, no. 7, pp. 2938-2949 . https://doi.org/10.1039/d0fo02976a
The aim of the study was to implement a gastric digestion step using recombinant human gastric lipase (rHGL) in an in vitro pediatric gastro-intestinal digestion model to achieve a physiologically relevant gastric contribution to total gastro-intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7437c9be1eb02eb6aedbd059a302e86
https://doi.org/10.1039/d0fo02976a
https://doi.org/10.1039/d0fo02976a
Autor:
Ragna Berthelsen, Korbinian Löbmann, Nele-Johanna Hempel, Matthias Manne Knopp, Flemming Morsch
Publikováno v:
Journal of Pharmaceutical Sciences. 110:155-163
Microwave-induced in situ amorphization is a promising approach to circumvent stability and manufacturing issues associated with amorphous solid dispersions (ASD). Using in situ amorphization, the crystalline state of the drug is converted into its a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bd19fb05b67026531534809154cef7
https://doi.org/10.1016/j.xphs.2020.10.013
https://doi.org/10.1016/j.xphs.2020.10.013