P-I metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis

Autor: Shreesha K. Bhat, Manjunath B. Joshi, Sampara Vasishta, Rajesh N. Jagadale, Setlur G. Biligiri, Monika A. Coronado, Raghuvir K. Arni, Kapaettu Satyamoorthy

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021)

Abstract Background: Snake venoms are composed of pharmacologically active proteins that are evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as a source of bioactive molecules in treating numerous diseases. Re

Externí odkaz: https://doaj.org/article/ba329ed15d404646b6c07da318d4ea98

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Autor: Raphael J. Eberle, Ian Gering, Markus Tusche, Philipp N. Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S. Olivier, Marcos S. Amaral, Raghuvir K. Arni, Dieter Willbold, Mônika A. Coronado

Publikováno v: Pharmaceuticals, Vol 15, Iss 5, p 540 (2022)

The C30 endopeptidase (3C-like protease; 3CLpro) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and, hence, is a promising drug targ

Externí odkaz: https://doaj.org/article/86df6e13919542f8871f462489b7f278

The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CLpro In Vitro

Autor: Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Ian Gering, Dieter Willbold, Raghuvir K. Arni, Monika A. Coronado

Publikováno v: Viruses, Vol 13, Iss 5, p 873 (2021)

Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and 3.1 million losses globally up to now. The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide, res

Externí odkaz: https://doaj.org/article/d7306cc808ef4c2a9d048b59fdd52336

Omics Tools Applied to the Study of Chagas Disease Vectors: Cytogenomics and Genomics

Autor: Kelly Cristine Borsatto, Monika A. Coronado, Raghuvir K. Arni, Kaio Cesar Chaboli Alevi

Publikováno v: Am J Trop Med Hyg

Chagas disease is an illness caused by the protozoan Trypanosoma cruzi that is distributed in 21 countries of Latin America. The main way of transmission of T. cruzi is through the feces of triatomines infected with the parasite. With technological a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9c6a6b06980b51e30c95251371a4e9
https://doi.org/10.4269/ajtmh.20-1047

Promising natural compounds against flavivirus proteases: Citrus flavonoids hesperetin and hesperidin

Autor: Marcos Serrou do Amaral, Monika A. Coronado, Dieter Willbold, Raghuvir K. Arni, Raphael Josef Eberle, Danilo S. Olivier

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Plants, Vol 10, Iss 2183, p 2183 (2021)
Plants
Volume 10
Issue 10
Plants 10(10), 2183-(2021). doi:10.3390/plants10102183

Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cc5474a297811d94441cef26cb8144