Výsledky vyhledávání - "Raghunandan Mahadeva"

Akademický článek

Impaired iron recycling from erythrocytes is an early hallmark of aging

Autor: Patryk Slusarczyk, Pratik Kumar Mandal, Gabriela Zurawska, Marta Niklewicz, Komal Chouhan, Raghunandan Mahadeva, Aneta Jończy, Matylda Macias, Aleksandra Szybinska, Magdalena Cybulska-Lubak, Olga Krawczyk, Sylwia Herman, Michal Mikula, Remigiusz Serwa, Małgorzata Lenartowicz, Wojciech Pokrzywa, Katarzyna Mleczko-Sanecka

Publikováno v: eLife, Vol 12 (2023)

Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by splenic red pulp macrophage

Externí odkaz: https://doaj.org/article/d6c8686415fe4090aee6edece8741fc1

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Akademický článek

A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins

Autor: Snehal Nirgude, Shahana M. V., Febina Ravindran, Sujeet Kumar, Shivangi Sharma, Raghunandan Mahadeva, Anisha Mhatre, Subhas S. Karki, Bibha Choudhary

Publikováno v: Molecules, Vol 28, Iss 13, p 5226 (2023)

Despite several treatment options for blood cancer, mortality remains high due to relapse and the disease’s aggressive nature. Elevated levels of HSP90, a molecular chaperone essential for protein folding, are associated with poor prognosis in leuk

Externí odkaz: https://doaj.org/article/49a6da36f66247a29386de550b4f12b6

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Akademický článek

ST08 Altered NF-κB Pathway in Breast Cancer Cells In Vitro as Revealed by miRNA-mRNA Analysis and Enhanced the Effect of Cisplatin on Tumour Reduction in EAC Mouse Model

Autor: Snehal Nirgude, Sagar Desai, Raghunandan Mahadeva, Febina Ravindran, Bibha Choudhary

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

ST08 is a novel curcumin derivative that exhibited apoptotic and anti-migratory activity in MDA-MB-231, triple-negative breast cancer cells reported earlier. In this study, we further explored the anticancer properties of ST08. ST08 reduced tumor bur

Externí odkaz: https://doaj.org/article/faa19e0edb8843e7a1c1132bed4d79bf

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Akademický článek

Curcumin derivative 1, 2-bis [(3E, 5E)-3, 5-bis [(2-chlorophenyl) methylene]-4-oxo-1-piperidyl] ethane-1, 2-dione (ST03) induces mitochondria mediated apoptosis in ovarian cancer cells and inhibits tumor progression in EAC mouse model

Autor: Jinsha Koroth, Raghunandan Mahadeva, Febina Ravindran, Tanvi R Parashar, Vinay Teja, Subhas S Karki, Bibha Choudhary

Publikováno v: Translational Oncology, Vol 15, Iss 1, Pp 101280- (2022)

Curcumin is known for its anticancer properties, but its clinical application is limited due to its poor bioavailability and chemical stability. In this study we report the curcumin derivative, ST03 (1,2-bis[(3E,5E)-3,5-bis[(2-chlorophenyl)methylene]

Externí odkaz: https://doaj.org/article/b2fe654f1f5b4ef0a1c015dfc2ae915f

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Akademický článek

Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines

Autor: Jinsha Koroth, Snehal Nirgude, Shweta Tiwari, Vidya Gopalakrishnan, Raghunandan Mahadeva, Sujeet Kumar, Subhas S. Karki, Bibha Choudhary

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-16 (2019)

Abstract Background Curcumin is known for its multitude of medicinal properties, including anti-cancer and migrastatic activity. Efforts to overcome poor bioavailability, stability, and side effects associated with the higher dose of curcumin has led

Externí odkaz: https://doaj.org/article/376d80c1b2a24e75b6214d72b247b873

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Akademický článek

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

Autor: Snehal Nirgude, Raghunandan Mahadeva, Jinsha Koroth, Sujeet Kumar, Kothanahally S. Sharath Kumar, Vidya Gopalakrishnan, Subhas S Karki, Bibha Choudhary

Publikováno v: Molecules, Vol 25, Iss 19, p 4499 (2020)

Purpose: Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. Newer curcumin derivatives are being explored to overcome limitations of curcumin like low bioavailability, stability, and side effect

Externí odkaz: https://doaj.org/article/3eaafff94da64d5ca5fef6b76406a6ef

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