Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons

Autor: Uppala Radhakrishna, Senthilkumar Sadhasivam, Rupa Radhakrishnan, Ariadna Forray, Srinivas B. Muvvala, Raghu P. Metpally, Saumya Patel, Rakesh M. Rawal, Sangeetha Vishweswaraiah, Ray O. Bahado-Singh, Swapan K. Nath

Publikováno v: Frontiers in Genetics, Vol 14 (2024)

Background: Neonatal opioid withdrawal syndrome (NOWS), arises due to increased opioid use during pregnancy. Cytochrome P450 (CYP) enzymes play a pivotal role in metabolizing a wide range of substances in the human body, including opioids, other drug

Externí odkaz: https://doaj.org/article/4dbab8a847cb42749fcafff78c1a1426

Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population

Autor: Jason E. Miller, Raghu P. Metpally, Thomas N. Person, Sarathbabu Krishnamurthy, Venkata Ramesh Dasari, Manu Shivakumar, Daniel R. Lavage, Adam M. Cook, David J. Carey, Marylyn D. Ritchie, Dokyoon Kim, Radhika Gogoi, on behalf of the DiscovEHR collaboration

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)

Abstract Background Endometrial cancer (EMCA) is the fifth most common cancer among women in the world. Identification of potentially pathogenic germline variants from individuals with EMCA will help characterize genetic features that underlie the di

Externí odkaz: https://doaj.org/article/a1e01515668243b0bcba223992ee402e

Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer’s Disease

Autor: Ray O. Bahado-Singh, Uppala Radhakrishna, Juozas Gordevičius, Buket Aydas, Ali Yilmaz, Faryal Jafar, Khaled Imam, Michael Maddens, Kshetra Challapalli, Raghu P. Metpally, Wade H. Berrettini, Richard C. Crist, Stewart F. Graham, Sangeetha Vishweswaraiah

Publikováno v: Cells, Vol 11, Iss 11, p 1744 (2022)

Background: Despite extensive efforts, significant gaps remain in our understanding of Alzheimer’s disease (AD) pathophysiology. Novel approaches using circulating cell-free DNA (cfDNA) have the potential to revolutionize our understanding of neuro

Externí odkaz: https://doaj.org/article/26aa0b56552f485dae0c87a376ca3611

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.

Autor: Praveen, Kavita¹ (AUTHOR), Patel, Gaurang C.² (AUTHOR), Gurski, Lauren¹ (AUTHOR), Ayer, Ariane H.¹ (AUTHOR), Persaud, Trikaladarshi¹ (AUTHOR), Still, Matthew D.² (AUTHOR), Miloscio, Lawrence¹ (AUTHOR), Van Zyl, Tavé² (AUTHOR), Di Gioia, Silvio Alessandro¹ (AUTHOR), Brumpton, Ben^3,4,5 (AUTHOR), Krebs, Kristi⁶ (AUTHOR), Åsvold, Bjørn Olav^3,4,7 (AUTHOR), Chen, Esteban¹ (AUTHOR), Chavali, Venkata R. M.⁸ (AUTHOR), Fury, Wen² (AUTHOR), Gudiseva, Harini V.⁸ (AUTHOR), Hyde, Sarah⁹ (AUTHOR), Jorgenson, Eric¹ (AUTHOR), Lefebvre, Stephanie⁹ (AUTHOR), Li, Dadong¹ (AUTHOR)

Publikováno v: Communications Biology. 10/3/2022, Vol. 5 Issue 1, p1-15. 15p.

Artificial Intelligence and Circulating Cell-Free DNA Methylation Profiling: Mechanism and Detection of Alzheimer's Disease.

Autor: Bahado-Singh, Ray O.^1,2 (AUTHOR) dr.faryaljafar@gmail.com, Radhakrishna, Uppala² (AUTHOR) drkshetra93@gmail.com, Gordevičius, Juozas³ (AUTHOR) juozas@vugene.us, Aydas, Buket⁴ (AUTHOR) buketaydas@gmail.com, Yilmaz, Ali^1,5 (AUTHOR) ali.yilmaz@beaumont.org, Jafar, Faryal² (AUTHOR), Imam, Khaled⁶ (AUTHOR) khaled.imam@beaumont.edu, Maddens, Michael⁶ (AUTHOR) mmaddens@beaumont.edu, Challapalli, Kshetra² (AUTHOR), Metpally, Raghu P.⁷ (AUTHOR) mrprao@gmail.com, Berrettini, Wade H.^7,8 (AUTHOR) crist@pennmedicine.upenn.edu, Crist, Richard C.⁸ (AUTHOR), Graham, Stewart F.^1,2,5 (AUTHOR) stewart.graham@beaumont.edu, Vishweswaraiah, Sangeetha² (AUTHOR) uppalar99@gmail.com

Publikováno v: Cells (2073-4409). Jun2022, Vol. 11 Issue 11, p1744-1744. 19p.