Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections

Autor: Parker, Matthew D, Shaw, Hazel, Shehata, Ola M, Lindsey, Benjamin B, Shah, Dhruv R, Hsu, Sharon, Keeley, Alexander J, Partridge, David G, Leary, Shay, Cope, Alison, State, Amy, Johnson, Katie, Ali, Nasar, Raghei, Rasha, Heffer, Joe, Smith, Nikki, Zhang, Peijun, Gallis, Marta, Louka, Stavroula F, Hornsby, Hailey R, Alamri, Hatoon, Whiteley, Max, Foulkes, Benjamin H, Christou, Stella, Wolverson, Paige, Pohare, Manoj, Hansford, Samantha E, Green, Luke R, Evans, Cariad, Raza, Mohammad, Wang, Dennis, Firth, Andrew, Edgar, James, Gaudieri, Silvana, Mallal, Simon, COVID-19 Genomics UK (COG-UK) Consortium, Collins, Mark O, Peden, Andrew A, De Silva, Thushan I

B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the SARS-CoV-2 genome. Applying ou

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Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections.

Autor: Parker MD; Sheffield Biomedical Research Centre, The University of Sheffield, Sheffield, UK.; Sheffield Bioinformatics Core, The University of Sheffield, Sheffield, UK., Stewart H; Department of Pathology, University of Cambridge, Cambridge, UK., Shehata OM; Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, UK., Lindsey BB; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Shah DR; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Hsu S; Sheffield Bioinformatics Core, The University of Sheffield, Sheffield, UK.; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Keeley AJ; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Partridge DG; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Leary S; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia., Cope A; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., State A; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Johnson K; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Ali N; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Raghei R; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Heffer J; IT Services, The University of Sheffield, Sheffield, UK., Smith N; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Zhang P; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Gallis M; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Louka SF; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Hornsby HR; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Alamri H; Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, UK., Whiteley M; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Foulkes BH; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Christou S; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Wolverson P; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Pohare M; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Hansford SE; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Green LR; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK., Evans C; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Raza M; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Wang D; Sheffield Biomedical Research Centre, The University of Sheffield, Sheffield, UK.; Sheffield Bioinformatics Core, The University of Sheffield, Sheffield, UK.; Department of Computer Science, The University of Sheffield, Sheffield, UK., Firth AE; Department of Pathology, University of Cambridge, Cambridge, UK., Edgar JR; Department of Pathology, University of Cambridge, Cambridge, UK., Gaudieri S; Department of Computer Science, The University of Sheffield, Sheffield, UK.; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; School of Human Sciences, University of Western Australia, Crawley, WA, Australia., Mallal S; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; School of Human Sciences, University of Western Australia, Crawley, WA, Australia., Collins MO; Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, UK., Peden AA; Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, UK., de Silva TI; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. t.desilva@sheffield.ac.uk.; The Florey Institute for Host-Pathogen Interactions & Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, UK. t.desilva@sheffield.ac.uk.

Publikováno v: Communications biology [Commun Biol] 2022 Jul 05; Vol. 5 (1), pp. 666. Date of Electronic Publication: 2022 Jul 05.