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pro vyhledávání: '"Raghavendra Jampala"'
Autor:
Isabella A. Graef, Jonathan Fox, Mark Miller, Miki S. Park, Arindom Pal, Jared Khan, William K. Chan, Uma Sinha, Hyun Joo, Mamoun M. Alhamadsheh, Wabel Albusairi, Dengpan Liang, Fang Liu, Neil Kumar, Raghavendra Jampala, Robert Zamboni, Beverly Pappas, Tariqul Haque Tuhin, Marjon Faaij
Publikováno v:
Journal of Medicinal Chemistry. 61:7862-7876
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a fatal disease with no available disease-modifying therapies. While pathogenic TTR mutations (TTRm) destabilize TTR tetramers, the T119M variant stabilizes TTRm and prevents disease. A comparis