Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Raghavendra G. Mirmira"'
Autor:
Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. Nakayasu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-c
Externí odkaz:
https://doaj.org/article/6b57b4f4064a4390ae8f0840effa40ac
Autor:
Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33838- (2024)
Hypusine is an amino acid synthesized by the enzyme deoxyhypusine synthase (DHPS). It is critical for the activity of eukaryotic translation initiation factor 5A (EIF5A). We reported that hypusination i) in macrophages supports the innate response to
Externí odkaz:
https://doaj.org/article/02fd8b1c2fd24f64a472e36bac86f199
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
The pathogeneses of type 1 and type 2 diabetes involve the progressive loss of functional beta cell mass, primarily attributed to cellular demise and/or dedifferentiation. While the scientific community has devoted significant attention to unraveling
Externí odkaz:
https://doaj.org/article/537b142433ab4acea6bb0f6bf4147f51
Autor:
Milene C. Vallejo, Soumyadeep Sarkar, Emily C. Elliott, Hayden R. Henry, Samantha M. Powell, Ivo Diaz Ludovico, Youngki You, Fei Huang, Samuel H. Payne, Sasanka Ramanadham, Emily K. Sims, Thomas O. Metz, Raghavendra G. Mirmira, Ernesto S. Nakayasu
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract Extracellular vesicles play major roles in cell-to-cell communication and are excellent biomarker candidates. However, studying plasma extracellular vesicles is challenging due to contaminants. Here, we performed a proteomics meta-analysis o
Externí odkaz:
https://doaj.org/article/a7d72d2c446c44ff926f2c19bd0e61eb
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101938- (2023)
Summary: Investigating the immune attack on β cells is critical to understanding autoimmune diabetes. Here, we present a protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas, followed by mass cytometric analyses. Thi
Externí odkaz:
https://doaj.org/article/7aa06b80963f44238fcbb5c634fb18de
Autor:
Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M. Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A. Wood, Yao-Ying Ma, X. Charlie Dong, Raghavendra G. Mirmira, Tao Lu
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1457 (2023)
Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signalin
Externí odkaz:
https://doaj.org/article/fe15b2cdd26a480d8b9e5d43cb4c7d13
Autor:
Raghavendra G. Mirmira, Rohit N. Kulkarni, Pingwen Xu, Tina Drossos, Krista Varady, Kristen L. Knutson, Sirimon Reutrakul, Pamela Martyn-Nemeth, Robert M. Sargis, Amisha Wallia, Arleen M. Tuchman, Jill Weissberg-Benchell, Kirstie K. Danielson, Scott A. Oakes, Celeste C. Thomas, Brian T. Layden, Sarah C. May, Michelle Burbea Hoffmann, Eleonora Gatta, Julian Solway, Louis H. Philipson
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus of the Chicago Biomedical Consortium’s 19th annual symposium, “Stress and Human Health:
Externí odkaz:
https://doaj.org/article/229e064d51b9496b995463d9593c8865
Autor:
Farooq Syed, Divya Singhal, Koen Raedschelders, Preethi Krishnan, Robert N. Bone, Madeline R. McLaughlin, Jennifer E. Van Eyk, Raghavendra G. Mirmira, Mei-Ling Yang, Mark J. Mamula, Huanmei Wu, Xiaowen Liu, Carmella Evans-Molina
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104379- (2023)
Summary: Background: Stress responses within the β cell have been linked with both increased β cell death and accelerated immune activation in type 1 diabetes (T1D). At present, information on the timing and scope of these responses as well as dise
Externí odkaz:
https://doaj.org/article/e4d20da624eb40df994a03c5fc5bd7ca
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9996 (2023)
Nonalcoholic fatty liver disease (NAFLD) is a range of pathologies arising from fat accumulation in the liver in the absence of excess alcohol use or other causes of liver disease. Its complications include cirrhosis and liver failure, hepatocellular
Externí odkaz:
https://doaj.org/article/16753ec3c41c4f9d802225621ba697db
Autor:
Rebecca S. Aguirre, Abhishek Kulkarni, Matthew W. Becker, Xiaoyong Lei, Soumyadeep Sarkar, Sasanka Ramanadham, Edward A. Phelps, Ernesto S. Nakayasu, Emily K. Sims, Raghavendra G. Mirmira
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101545- (2022)
Background: Type 1 diabetes (T1D) is a complex autoimmune disorder whose pathogenesis involves an intricate interplay between β cells of the pancreatic islet, other islet cells, and cells of the immune system. Direct intercellular communication with
Externí odkaz:
https://doaj.org/article/678c7a50544c41d5811309036b14ae85