Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Raghavender Medishetti"'
Autor:
Keerthana Balamurugan, Raghavender Medishetti, Pallavi Rao, Rahul Varma K, Kiranam Chatti, Kishore V.L. Parsa
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101819- (2022)
Summary: In this report, we describe an approach to generate a zebrafish larval model of lipid accumulation that can be used as an in vivo system to study hyperlipidemic conditions such as atherosclerosis. Furthermore, we detail steps on staining tec
Externí odkaz:
https://doaj.org/article/b5a51f5e18544b4a9546639a20023c5f
Autor:
Raghavender Medishetti, Keerthana Balamurugan, Krishnaveni Yadavalli, Rita Rani, Aarti Sevilimedu, Anil Kumar Challa, Kishore Parsa, Kiranam Chatti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101779- (2022)
Summary: The application of CRISPR has greatly facilitated genotype-phenotype studies of human disease models. In this protocol, we describe CRISPR-Cas9-induced gene knockout in zebrafish, utilizing purified Cas9 protein and in vitro-transcribed sgRN
Externí odkaz:
https://doaj.org/article/324fb06899d64991bbddeedcf320850e
Autor:
Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kishore V.L. Parsa
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103766- (2022)
Summary: Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-expose
Externí odkaz:
https://doaj.org/article/fe4f6b2971f64ef89092d79c791f559d
Autor:
Harshavardhan Bhuktar, Sharda Shukla, Kumar Reddy Kakularam, Srikanth Battu, Manupati Srikanth, Susmita Srivastava, Raghavender Medishetti, Pooja Ram, P.C. Jagadish, Mahaboobkhan Rasool, Sandipan Chakraborty, Nooruddin Khan, Pallu Reddanna, Srinivas Oruganti, Manojit Pal
Publikováno v:
Bioorganic Chemistry. 138:106606
Autor:
Sharda Shukla, R. Nishanth Rao, Harshavardhan Bhuktar, Rebecca Kristina Edwin, Trinath Jamma, Raghavender Medishetti, Sharmistha Banerjee, Varadaraj Bhat Giliyaru, Gautham G. Shenoy, Srinivas Oruganti, Parimal Misra, Manojit Pal
Publikováno v:
Bioorganic Chemistry. 134:106452
Autor:
Jetta Sandeep, Kumar, Gangireddy Sujeevan, Reddy, Raghavender, Medishetti, Kazi, Amirul Hossain, B, Thirupataiah, Jhansi, Edelli, Shilpak, Dilip Bele, Rebecca, Kristina Edwin, Alex, Joseph, Gautham G, Shenoy, C, Mallikarjuna Rao, Manojit, Pal
Publikováno v:
Bioorganic Chemistry. 124:105857
Addressing the increasing incidences of cancer worldwide along with the multifaceted problem of drug resistance via development of new anticancer agents has become an essential goal. Due to the known cytotoxic effects and reported Akt inhibitory pote
Autor:
B, Thirupataiah, Guntipally, Mounika, Gangireddy, Sujeevan Reddy, Jetta, Sandeep Kumar, Ravikumar, Kapavarapu, Raghavender, Medishetti, Jayesh, Mudgal, Jessy E, Mathew, Gautham G, Shenoy, C, Mallikarjuna Rao, Kiranam, Chatti, Kishore, V L Parsa, Manojit, Pal
Publikováno v:
Bioorganic chemistry. 115
In spite of possessing a wide range of pharmacological properties the anti-inflammatory activities of isoquinolin-1(2H)-ones were rarely known or explored earlier. PDE4 inhibitors on the other hand in addition to their usefulness in treating inflamma
Autor:
Gangireddy Sujeevan, Reddy, Rajamanikkam, Kamaraj, Kazi Amirul, Hossain, Jetta Sandeep, Kumar, B, Thirupataiah, Raghavender, Medishetti, N, Sushma Sri, Parimal, Misra, Manojit, Pal
Publikováno v:
Bioorganic chemistry. 116
A series of indole based novel Schiff bases was designed as potential agonists of 5-HT
Autor:
Aarti Sevilimedu, Marina Rajadurai, Pushkar Kulkarni, Uday Saxena, Raghavender Medishetti, Surendar Basaveni, Swapna Yellanki
Publikováno v:
Current Nanomedicine. 9:173-181
Background: Plasma pharmacokinetic (PK) properties of oral or injectable drugs dictate whether the drug is clinically viable or not. Poor PK properties often result in termination of the development of the drug. Optimizing PK properties of drugs is a
Autor:
Kishore V. L. Parsa, Jayesh Mudgal, E.V.V. Shivaji Ramarao, Jetta Sandeep Kumar, Ramudu Bankala, Hari Maduri Doss, Mahaboobkhan Rasool, Manojit Pal, Rajnikanth Sunke, Pushkar Kulkarni, B. Thirupataiah, Ravikumar Kapavarapu, Gautham G. Shenoy, Raghavender Medishetti, Jessy Elizabeth Mathew
Publikováno v:
European Journal of Medicinal Chemistry. 174:198-215
A new class of PDE4 inhibitors were designed and synthesized via the InCl3 mediated heteroarylation of indoles and their further derivatization through the Pd(II)-catalyzed C H activation strategy. This effort allowed us to discover a series of 2-(1H