Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Raghavan Varadarajan"'
Autor:
Arun Sharma, Neelam Singh, Munmun Bhasin, Prabhakar Tiwari, Pankaj Chopra, Raghavan Varadarajan, Ramandeep Singh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26 TA modules of M. tuberculosis. We report that
Externí odkaz:
https://doaj.org/article/f526d99801dd4bb8a053aa9241d7a868
Autor:
Zaolan Liang, Xia Lin, Lihong Sun, Kimberly M. Edwards, Wenjun Song, Hailiang Sun, Yanmin Xie, Fangmei Lin, Shiman Ling, Tingting Liang, Biying Xiao, Jiaqi Wang, Min Li, Chin-Yu Leung, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Min Z. Levine, Malik Peiris, Robert Webster, Vijaykrishna Dhanasekaran, Nancy H. L. Leung, Benjamin J. Cowling, Richard J. Webby, Mariette Ducatez, Mark Zanin, Sook-San Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reacti
Externí odkaz:
https://doaj.org/article/222177c2a96944b098415e28af694ad7
Autor:
Janice Z. Jia, Carolyn A. Cohen, Haogao Gu, Milla R. McLean, Raghavan Varadarajan, Nisha Bhandari, Malik Peiris, Gabriel M. Leung, Leo L. M. Poon, Tim Tsang, Amy W. Chung, Benjamin J. Cowling, Nancy H. L. Leung, Sophie A. Valkenburg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cross-reactive antibodies with Fc receptor (FcR) effector functions may mitigate pandemic virus impact in the absence of neutralizing antibodies. In this exploratory study, we use serum from a randomized placebo-controlled trial of seasonal
Externí odkaz:
https://doaj.org/article/c15b260c86f84dffa03009a6bb0b59de
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Single synonymous codon mutations typically have only minor or no effects on gene function. Here, we estimate the effects on cell growth of ~ 200 single synonymous codon mutations in an operonic context by mutating almost all posi
Externí odkaz:
https://doaj.org/article/b5ca4a075386476fb5f30441d56673a7
Autor:
Nidhi Mittal, Sahil Kumar, Raju S. Rajmani, Randhir Singh, Céline Lemoine, Virginie Jakob, Sowrabha BJ, Nayana Jagannath, Madhuraj Bhat, Debajyoti Chakraborty, Suman Pandey, Aurélie Jory, Suba Soundarya SA, Harry Kleanthous, Patrice Dubois, Rajesh P. Ringe, Raghavan Varadarajan
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract With the rapid emergence of variants of concern (VOC), the efficacy of currently licensed vaccines has reduced drastically. VOC mutations largely occur in the S1 subunit of Spike. The S2 subunit of SARS-CoV-2 is conserved and thus more likel
Externí odkaz:
https://doaj.org/article/0f5ee1238ed84d02b7ace45e58cd98b6
Autor:
Janice Z. Jia, Carolyn A. Cohen, Haogao Gu, Milla R. McLean, Raghavan Varadarajan, Nisha Bhandari, Malik Peiris, Gabriel M. Leung, Leo L. M. Poon, Tim Tsang, Amy W. Chung, Benjamin J. Cowling, Nancy H. L. Leung, Sophie A. Valkenburg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/dbcc812df33143d0a5c9724faf5629b8
Autor:
Nirmal Kumar, Irshad Maajid Taily, Charandeep Singh, Sahil Kumar, Raju S Rajmani, Debajyoti Chakraborty, Anshul Sharma, Priyanka Singh, Krishan Gopal Thakur, Raghavan Varadarajan, Rajesh P Ringe, Prabal Banerjee, Indranil Banerjee
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011358 (2023)
Rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) poses enormous challenge in the development of broad-spectrum antivirals that are effective against the existing and emerging viral strains. V
Externí odkaz:
https://doaj.org/article/10c226cafb564cada610602350982a35
Autor:
Mohammad Suhail Khan, Virginie Jakob, Randhir Singh, Raju S. Rajmani, Sahil Kumar, Céline Lemoine, Harry Kleanthous, Rajesh P. Ringe, Patrice M. Dubois, Raghavan Varadarajan
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2759 (2023)
Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized rec
Externí odkaz:
https://doaj.org/article/9e577797552241f5869c24ee121513ff
Autor:
Shahbaz Ahmed, Gopinath Chattopadhyay, Kavyashree Manjunath, Munmun Bhasin, Neelam Singh, Mubashir Rasool, Sayan Das, Varsha Rana, Neha Khan, Debarghya Mitra, Aparna Asok, Ramandeep Singh, Raghavan Varadarajan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon. While the toxin has a conserved fold, the antitoxins are structurally
Externí odkaz:
https://doaj.org/article/c702b2a39b394e2fa11e604654d0febc
Autor:
Gopinath Chattopadhyay, Jayantika Bhowmick, Kavyashree Manjunath, Shahbaz Ahmed, Parveen Goyal, Raghavan Varadarajan
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010334 (2022)
Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such globa
Externí odkaz:
https://doaj.org/article/d704902dd2074373bf87b1ed3df308bd