Výsledky vyhledávání - "Raghava N. Sriramaneni"

Akademický článek

Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy

Autor: Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris, Linda A. Schuler

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)

Abstract Background Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infilt

Externí odkaz: https://doaj.org/article/ed62145c75cf435aa09efab35a43623c

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Akademický článek

Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment fo

Externí odkaz: https://doaj.org/article/5182a8b990d848bdaa69308ac2077051

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Akademický článek

Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer

Autor: Amber M. Bates, Ryan J. Brown, Alexander A. Pieper, Luke M. Zangl, Ian Arthur, Peter M. Carlson, Trang Le, Gustavo A. Sosa, Paul A. Clark, Raghava N. Sriramaneni, KyungMann Kim, Ravi B. Patel, Zachary S. Morris

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Surgical resection or hypo-fractionated radiation therapy (RT) in early-stage non-small cell lung cancer (NSCLC) achieves local tumor control, but metastatic relapse remains a challenge. We hypothesized that immunotherapy with anti-CTLA-4 and bempega

Externí odkaz: https://doaj.org/article/a1b857248b16405ead2ae0e0249723e4

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Akademický článek

Tumor-Specific Antibody, Cetuximab, Enhances the In Situ Vaccine Effect of Radiation in Immunologically Cold Head and Neck Squamous Cell Carcinoma

Autor: Won Jong Jin, Amy K. Erbe, Ciara N. Schwarz, Abigail A. Jaquish, Bryce R. Anderson, Raghava N. Sriramaneni, Justin C. Jagodinsky, Amber M. Bates, Paul A. Clark, Trang Le, Keng-Hsueh Lan, Yi Chen, KyungMann Kim, Zachary S. Morris

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

In head and neck squamous cell carcinoma (HNSCC) tumors that over-expresses huEGFR, the anti-EGFR antibody, cetuximab, antagonizes tumor cell viability and sensitizes to radiation therapy. However, the immunologic interactions between cetuximab and r

Externí odkaz: https://doaj.org/article/cb1c402282874fdc932a12949b4cd965

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Akademický článek

In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response

Autor: Claire C. Baniel, Clinton M. Heinze, Anna Hoefges, Elizabeth G. Sumiec, Jaquelyn A. Hank, Peter M. Carlson, Won Jong Jin, Ravi B. Patel, Raghava N. Sriramaneni, Stephen D. Gillies, Amy K. Erbe, Ciara N. Schwarz, Alexander A. Pieper, Alexander L. Rakhmilevich, Paul M. Sondel, Zachary S. Morris

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

In a syngeneic murine melanoma (MEL) model, we recently reported an in situ vaccination response to combined radiation (RT) and intra-tumoral (IT) injection of anti-GD2 hu14. 18-IL2 immunocytokine (IC). This combined treatment resulted in 71% complet

Externí odkaz: https://doaj.org/article/69d352c38672413f9676b26e4741f6de

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Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization

Autor: Justin C Jagodinsky, Amber M Bates, Paul A Clark, Raghava N Sriramaneni, Thomas C Havighurst, Ishan Chakravarty, Erin J Nystuen, KyungMann Kim, Paul M Sondel, Won Jong Jin, Zachary S Morris

Publikováno v: Journal for immunotherapy of cancer. 10(10)

BackgroundRadiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210bc5f324f912410012bec30f7f991f
https://pubmed.ncbi.nlm.nih.gov/36192087

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