Výsledky vyhledávání - "Raghav Joshi"

Akademický článek

Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFα-antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure

Autor: Hilal Hachem, Amandeep Godara, Courtney Schroeder, Daniel Fein, Hashim Mann, Christian Lawlor, Jill Marshall, Andreas Klein, Debra Poutsiaka, Janis L. Breeze, Raghav Joshi, Paul Mathew

Publikováno v: Journal of Clinical and Translational Science, Vol 5 (2021)

Abstract Background: A feedforward pathological signaling loop generated by TNFα and IFN-γ synergy in the inflamed lung, driving CXCL-10 (IP-10) and CXCL-9 chemokine-mediated activated T-cell and monocyte/macrophage tissue recruitment, may define

Externí odkaz: https://doaj.org/article/c4c6d41a18a0445a99ebfdbb410e3b0f

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Email Sender Query Form for Web Applications

Autor: Raghav Joshi, Aniket Chandrawanshi, Anuroop Kanade, Kumar, Vikas, Kauleshwar Prasad, Bhawnani, Dinesh Kumar

For contacting a website owner for asking queries or sending requests via the email provided on the website, a user needs to open their gmail/any other mailing account and then send a mail. The objective of our research is to enhance the user experie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16045026a831db99fcae4b60f926bdb3

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Aberrant integrin αv and α5 expression in prostate adenocarcinomas and bone-metastases is consistent with a bone-colonizing phenotype

Autor: Raghav Joshi, Ming Zhou, Wenying Ren, Stephen P. Naber, Paul Mathew, Pavel Kopach, Brendan Connell

Publikováno v: Transl Androl Urol

Background Collaborative signaling between fibronectin-binding αv and α5 integrins has been implicated in the lethal dissemination of prostate cancer in the bone-metastatic niche, the major source of morbidity and mortality in the disease. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf6da29c21d54e6961f7fa2b56b1190
https://doi.org/10.21037/tau-19-763

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A Bispecific Antibody Targeting the αv and α5β1 Integrins Induces Integrin Degradation in Prostate Cancer Cells and Is Superior to Monospecific Antibodies

Autor: Wenying Ren, Raghav Joshi, Paul Mathew

Publikováno v: Molecular Cancer Research. 18:27-32

Fibronectin-binding integrins α5β1 and αv collaborate in prostate cancer–bone stromal interactions relevant to the colonization of the bone marrow microenvironment. Combinatorial inactivation of these integrins on prostate cancer cells was asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea8d1744920b62e2f4a8a618726b7a5
https://doi.org/10.1158/1541-7786.mcr-19-0442

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Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNF-α antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure

Autor: Hilal Hachem, Daniel Fein, Deborah Poutsiaka, Raghav Joshi, Andreas K. Klein, Courtney Schroeder, Christian Lawlor, Jill Marshall, Hashim Mann, Amandeep Godara, Paul Mathew, Janis L. Breeze

Publikováno v: medRxiv

BackgroundA feed-forward pathological signaling loop generated by TNFα and IFN-γ in inflamed lung tissue, driving CXCL-10 (IP-10) and CXCL-9 chemokine-mediated activated T-cell and monocyte/macrophage tissue recruitment, may define, sustain and amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597f65197d10b172582452996b0386a6
https://doi.org/10.1101/2021.05.29.21258010

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Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFα-antagonist therapy in hospitalized patients with severe and critical COVID-19 respiratory failure

Autor: Raghav Joshi, Andreas K. Klein, Paul Mathew, Daniel Fein, Janis L. Breeze, Hilal Hachem, Deborah Poutsiaka, Christian Lawlor, Amandeep Godara, Jill Marshall, Hashim Mann, Courtney Schroeder

Publikováno v: Journal of Clinical and Translational Science

Background:A feedforward pathological signaling loop generated by TNFα and IFN-γ synergy in the inflamed lung, driving CXCL-10 (IP-10) and CXCL-9 chemokine-mediated activated T-cell and monocyte/macrophage tissue recruitment, may define the inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23347d7d318fbcd9ff6a21349d54f722
http://europepmc.org/articles/PMC8376916

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Abstract 1902: The comparative superiority of a bispecific antibody targeting alpha v and alpha 5 integrins is uniquely characterized by induced degradation of integrins

Autor: Raghav Joshi, Wenying Ren, Paul Mathew

Publikováno v: Cancer Research. 79:1902-1902

Background: Bispecific antibody blockade of alpha v and alpha 5 integrins (BsAbαvα5) resulted in superior anti-tumor activity in prostate cancer cells over monospecific αv (MsAbαv) and α5 blockade (MsAbα5), singly or in combination. We sought t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e07ccd085b7efe47902769741c326fda
https://doi.org/10.1158/1538-7445.am2019-1902

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Abstract 114: Aberrant integrin alpha v and alpha 5 expression patterns in prostate adenocarcinomas and bone-metastases from prostate cancer are consistent with a bone-colonizing phenotype

Autor: Brendan Connell, Pavel Kopach, Wenying Ren, Raghav Joshi, Steven Naber, Paul Mathew

Publikováno v: Cancer Research. 79:114-114

Background: Fibronectin-binding αv and α5 integrins mediate homing, adhesive and survival interactions of prostate cancer cells with bone-marrow mesenchymal stromal cells. Monospecific αv integrin antibody therapy slowed progression of bone metast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1ef55951d4f3ea012da8d8c3a40510b
https://doi.org/10.1158/1538-7445.am2019-114

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