Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Raghad Muhsin Abdul-Karim"'
Autor:
Shubham Pant, Muhammad Furqan, Raghad Muhsin Abdul-Karim, Vincent Chung, Craig E. Devoe, Melissa Lynne Johnson, Alexis Diane Leal, Haeseong Park, Zev A. Wainberg, Esther Welkowsky, Christopher M. Haqq, Eileen Mary O'Reilly, Colin D. Weekes
Publikováno v:
Journal of Clinical Oncology. 40:TPS2701-TPS2701
TPS2701 Background: Mutations in KRAS and NRAS occur in one quarter of human solid tumors. The G12D allele is the most commonly occurring variant in pancreatic, colorectal, non-small cell lung, ovarian, biliary and gallbladder cancers. ELI-002 2P is
Autor:
Raghad Muhsin Abdul-Karim, Alexander I. Spira, Pratik S. Multani, Edna Chow Maneval, Shekeab Jauhari, Ann M. Johnson, Pamela N. Munster, Rongda Xu, Anneleen Daemen, Anthony W. Tolcher, S. Kummar, Maureen Duff, Manish R. Patel
Publikováno v:
Journal of Clinical Oncology. 39:2553-2553
2553 Background: ORIC-101 is a potent and selective, orally bioavailable, small molecule antagonist of the glucocorticoid receptor (GR). Preclinical studies have demonstrated that activation of GR signaling leads to decreased responsiveness to chemot
Autor:
Alexander Starodub, Victoria Smith, Christina Baccei, Raghad Muhsin Abdul-Karim, Michael Shafique, Gabriel Tinoco, Niharika B. Mettu, Patrick Chun, Sarina Anne Piha-Paul
Publikováno v:
Journal of Clinical Oncology. 39:2555-2555
2555 Background: Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive tumor environment and are a barrier to immune therapy. CD33 signaling in immature myeloid cells promotes expansion of MDSC and production of immunosuppressive
Autor:
Deborah Blythe Doroshow, Haizhou Zhang, Pankaj C. Patel, Haeseong Park, Ki Y. Chung, Leijun Hu, Keiko Nakai, Teresa A. Coleman, Raghad Muhsin Abdul-Karim, Jorge Chaves, John Qiang Wang
Publikováno v:
Journal of Clinical Oncology. 39:e14545-e14545
e14545 Background: BJ-001 is the first tumor-targeting Interleukin-15 (IL-15) fusion protein, composed of an integrin-binding Arg-Gly-Asp (RGD)-4C motif, linked with a human IgG1 Fc, and then a modified sushi domain of human IL-15Rα unit and a human
Autor:
Michalina Marszewska, Stephan Braun, Anna Patrikidou, Raghad Muhsin Abdul-Karim, Mikael Saulay, Damien Pouessel, Frederique Cantero, Yohann Loriot, Arvind Chaudhry, Hyo Jin Lee, Fabricio Racca, Rodryg Ramlau, Jean-Laurent Deville, Alejandro Gonzalez
Publikováno v:
Journal of Clinical Oncology. 39:437-437
437 Background: DZB is an oral small-molecule FGFR1/2/3 kinase inhibitor, which demonstrated antitumor activity in preclinical and clinical studies (in cholangiocarcinoma patients [pts] with FGFR2-driven tumors and in FGFR1-3-driven urothelial cancer