Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum

Autor: Sheila A. Lukehart, Barbara Molini, Alloysius Gomez, Charmie Godornes, Rebecca Hof, Mark C. Fernandez, Ragan A. Pitner, Sean A. Gray, Darrick Carter, Lorenzo Giacani, Caroline E. Cameron

Publikováno v: Vaccine. 40(52)

Syphilis continues to be a significant public health concern worldwide. The disease is endemic in many low- and middle-income countries, and rates have risen sharply in high-income countries over the last decade. The continued prevalence of infectiou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9042880825ce17872ec298d69fbb071
https://pubmed.ncbi.nlm.nih.gov/36376214

Structure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy

Autor: Pascal Fender, Hongjie Wang, Jenn Davis-Bergthold, André Lieber, Jiho Kim, Emilie Vassal-Stermann, Jaclyn Adams, Lauren Carter, Sean A. Gray, Jeffrey A. Ahlgren, Ragan A Pitner, Darrick Carter, Cheri Turner

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.6169. ⟨10.1038/s41598-019-42229-3⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 2019, 9 (1), pp.6169. ⟨10.1038/s41598-019-42229-3⟩

Disorganized intercellular junctions are critical for maintaining the integrity of solid epithelial tumors and prevent the infiltration of oncological therapies into the bulk of the malignancy. We have developed small, recombinant proteins which bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e733fa96915a3560ce1591a92048c5
https://doi.org/10.1038/s41598-019-42229-3