Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rafik Salama"'
Autor:
Steffen Grampp, James L. Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K. Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J. Ratcliffe, David R. Mole, Johannes Schödel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivat
Externí odkaz:
https://doaj.org/article/fe92f998e7f14012877889b0b60dd9cb
Autor:
Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J Ratcliffe, David R Mole, Johannes Schödel
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006872 (2017)
Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incom
Externí odkaz:
https://doaj.org/article/6b09644ca2b74a97a5428c0dec856c48
Autor:
Rafik Salama, Norma Masson, Peter Simpson, Lina Katrin Sciesielski, Min Sun, Ya-Min Tian, Peter John Ratcliffe, David Robert Mole
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134645 (2015)
General activation of hypoxia-inducible factor (HIF) pathways is classically associated with adverse prognosis in cancer and has been proposed to contribute to oncogenic drive. In clear cell renal carcinoma (CCRC) HIF pathways are upregulated by inac
Externí odkaz:
https://doaj.org/article/0365a0a4df53412d8170589c5f6df354
Autor:
Elisabetta Gamen, Eleanor Price, Daniela Pezzolla, Carla De Villiers, Mala Rohling, Judith Sayers, Carolina Roque Silva, Xin Sun, Rafik Salama, David Mole, Tammie Bishop, Christopher W Pugh, Robin Choudhury, Carolyn Carr, Joaquim Vieira, Paul Riley
In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf341dda07bb9a98db2459230de3ebbe
https://doi.org/10.21203/rs.3.rs-2496938/v1
https://doi.org/10.21203/rs.3.rs-2496938/v1
Background Hemiparesis and hemiplegia are commonly observed motor consequences of brain injury and infarction. Brain disorders such as traumatic brain injury (TBI), stroke (cerebrovascular accident, or CVA), and cerebral palsy (CP), as well as surgic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6a5a8b752c3929b8368cd3d8b098b9
https://doi.org/10.21203/rs.3.rs-1915432/v1
https://doi.org/10.21203/rs.3.rs-1915432/v1
Autor:
Mala Gunadasa-Rohling, Robin P. Choudhury, Rafik Salama, Daniela Pezzolla, Carolyn A. Carr, Eleonor Price, Christopher W. Pugh, Elisabetta Gamen, Paul R. Riley, Carla De Villiers, Tammie Bishop, David R. Mole, Joaquim M. Vieira
In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e823f8806863fd80e08c29d6d6f003
https://doi.org/10.21203/rs.3.rs-569151/v1
https://doi.org/10.21203/rs.3.rs-569151/v1
HIV (Human Immuno-deficiency Virus) infection has a multi system effect. some publications claimed deterioration of smell perception in HIV. In this study, we present our smell assessment in a group of HIV patients using market available tests. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35ac11524aa05954508cd1e8a3f2c72
https://doi.org/10.14293/s2199-1006.1.sor-.ppc7m7n.v1
https://doi.org/10.14293/s2199-1006.1.sor-.ppc7m7n.v1
Autor:
Rafik Salama, Olivia Lombardi, Hani Choudhry, Stephen J. Chanock, Virginia Schmid, David R. Mole, Peter J. Ratcliffe, Ran Li, Leandro M. Colli, Véronique N. Lafleur
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Emerging evidence suggests that dysregulation of oncogenic pathways requires precise tuning in order for cancer to develop. To test this, we examined the overlap between cis-acting elements of the hypoxia-inducible factor (HIF) pathway and cancer-sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d46e688ebd8f37cefc80699f2f4f228
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Leandro M. Colli, Rafik Salama, Silvia Halim, Véronique N. Lafleur, David R. Mole, Stephen J. Chanock, Virginia Schmid, Ran Li, Peter J. Ratcliffe, Olivia Lombardi
Publikováno v:
Cancer Research. 80:3436-3436
The purpose of this study was to determine whether specific components of the HIF-transcriptional pathway are under selective pressure during the development of cancer. Induction of HIF is a common feature of most cancers that frequently results from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d068ca4766f734c68ec72dd60857e8
https://doi.org/10.1158/1538-7445.am2020-3436
https://doi.org/10.1158/1538-7445.am2020-3436
Publikováno v:
Journal of Mental Health. 23:4-8
Government strategy for mental health places tackling stigma as a main priority. National initiatives have attempted to tackle stigma by challenging negative media reporting and the use of stereotyped representations of mental illness, with mixed res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ac55147b8112b66e7ffe342b1492cf
https://doi.org/10.3109/09638237.2013.815336
https://doi.org/10.3109/09638237.2013.815336