Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Rafik M Ghobrial"'
Publikováno v:
Transplantation Reports, Vol 3, Iss 4, Pp 21-28 (2018)
Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection. We showed previously that macrophage-specific deletion of RhoA or Rho
Externí odkaz:
https://doaj.org/article/4c97714d7f1b4401bd402f27afe3268a
Autor:
Malgorzata Kloc, Rafik M Ghobrial
Publikováno v:
Burns & Trauma, Vol 2, Iss 1, Pp 3-10 (2014)
The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation. This form of rejection is responsible for long-term failure of
Externí odkaz:
https://doaj.org/article/5f6f25149ccc494e9ebb5bb74c0526de
Autor:
Wojciech Lisik, Neelam Tejpal, Yongquan Gong, T Spencer Skelton, Malathesh Ganachari, Eric G Bremer, Malgorzata Kloc, Rafik M Ghobrial
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8020 (2009)
BACKGROUND:The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induce
Externí odkaz:
https://doaj.org/article/58e9a6af11bb41e786286a6e1bd373c6
Autor:
Dahai Liu, Xiu-Da Shen, Yuan Zhai, Wengsi Lam, Jingying Liao, Ronald W Busuttil, Rafik M Ghobrial
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6076 (2009)
BACKGROUND:Allograft tolerance of ACI (RT1(a)) recipients to WF (RT1(u)) hearts can be induced by allochimeric class I MHC molecules containing donor-type (RT1A(u)) immunogenic epitopes displayed on recipient-type (RT1A(a)) sequences. Here, we sought
Externí odkaz:
https://doaj.org/article/a5e6f297e55a438eb45698aa43ce9d91
Autor:
Maen Abdelrahim, Abdullah Esmail, Godsfavour Umoru, Kiersten Westhart, Ala Abudayyeh, Ashish Saharia, Rafik M. Ghobrial
Publikováno v:
Current Oncology, Vol 29, Iss 6, Pp 4267-4273 (2022)
Systemic combination therapy of immune checkpoint inhibitors and vascular endothelial growth factors have provided the basis for improved outcomes in select patients with unresectable or metastatic hepatocellular carcinoma. However, for patients with
Externí odkaz:
https://doaj.org/article/22cd82424e3848c59978206e5cdc5e83
Autor:
Maen Abdelrahim, Hadeel Al-Rawi, Abdullah Esmail, Jiaqiong Xu, Godsfavour Umoru, Fahad Ibnshamsah, Ala Abudayyeh, David Victor, Ashish Saharia, Robert McMillan, Ebtesam Al Najjar, Doaa Bugazia, Maryam Al-Rawi, Rafik M. Ghobrial
Publikováno v:
Current Oncology, Vol 29, Iss 5, Pp 3585-3594 (2022)
Background: The management of cholangiocarcinoma is continually reviewed on a current evidence basis to develop practice guidelines and consensus statements. However, the standardized treatment guidelines are still unclear for cholangiocarcinoma pati
Externí odkaz:
https://doaj.org/article/6e6e02d14cb8444d9a1263a635cb1dc4
Autor:
Mou Wen, Yuanlin Ying, Xiang Xiao, Preston R. Arnold, Guangchuan Wang, Xiufeng Chu, Rafik M. Ghobrial, Xian C. Li
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
BRD4 is a bromodomain extraterminal domain family member and functions primarily as a chromatin reader regulating genes involved in cell-fate decisions. Here, we bred Brd4fl/fl Ox40-Cre mice in which Brd4 was conditionally deleted in OX40-expressing
Externí odkaz:
https://doaj.org/article/b49ac9ddcb264861b53b11e0e8ad3b0f
Autor:
Ahmed Uosef, Arijita Subuddhi, Annie Lu, Henry V. Ubelaker, Christof Karmonik, Jarek Wosik, Rafik M. Ghobrial, Malgorzata Kloc
Publikováno v:
Journal of Magnetic Resonance Open, Vol 12, Iss , Pp 100085- (2022)
Gadolinium-based MRI contrast agent Dotarem is commonly used in the clinic. Free Gd3+ is very toxic. Because the crystallographic radius of Gd3+ and Ca2+ is very similar, Gd3+ can compete with Ca2+ in the regulations of cellular functions. Gadolinium
Externí odkaz:
https://doaj.org/article/132a4f1e0d9e46dfaadd38988576dc94
Autor:
Maen Abdelrahim, Abdullah Esmail, Jiaqiong Xu, Godsfavour Umoru, Hadeel Al-Rawi, Ashish Saharia, Ala Abudayyeh, David Victor, Robert McMillan, Sudha Kodali, Rafik M. Ghobrial
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundCholangiocarcinoma management is constantly being updated in view of existing evidence in order to establish practice guidelines and consensus statements. However, the available treatment guidelines to optimize outcomes for cholangiocarcino
Externí odkaz:
https://doaj.org/article/ceaf7288193c4b56bffd364946f83ee9
Autor:
Priyanka Chanana, Ahmed Uosef, Nicole Vaughn, Martha Suarez-Villagran, Rafik M. Ghobrial, Malgorzata Kloc, Jarek Wosik
Publikováno v:
Cells, Vol 11, Iss 5, p 757 (2022)
Magnetic resonance imaging (MRI) is widely used in diagnostic medicine. MRI uses the static magnetic field to polarize nuclei spins, fast-switching magnetic field gradients to generate temporal and spatial resolution, and radiofrequency (RF) electrom
Externí odkaz:
https://doaj.org/article/bd31fa091042406ab78905f8448ab32f