Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Rafick Pierre Sékaly"'
Autor:
Christina Gavegnano, Jessica H Brehm, Franck P Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J Hurwitz, Vincent C Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F Schinazi, Rafick Pierre Sékaly
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006740 (2017)
Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir establishment, maintenance, and expansion, remains a challenge. T cell homeostasis is a major drive
Externí odkaz:
https://doaj.org/article/4317a5f5021746d493577bcfb4b68481
Autor:
Oscar Blanch-Lombarte, Dan Ouchi, Esther Jimenez-Moyano, Julieta Carabelli, Miguel Angel Marin, Ruth Peña, Adam Pelletier, Aarthi Talla, Ashish Sharma, Judith Dalmau, José Ramón Santos, Rafick-Pierre Sékaly, Bonaventura Clotet, Julia G Prado
Publikováno v:
eLife, Vol 12 (2023)
The co-expression of inhibitory receptors (IRs) is a hallmark of CD8+ T-cell exhaustion (Tex) in people living with HIV-1 (PLWH). Understanding alterations of IRs expression in PLWH on long-term antiretroviral treatment (ART) remains elusive but is c
Externí odkaz:
https://doaj.org/article/212884b3996f4cf38d21dc4192521e0e
Autor:
Jacqueline Hernandez, Javier A. Tamargo, Sabrina Sales Martinez, Haley R. Martin, Adriana Campa, Rafick-Pierre Sékaly, Rebeka Bordi, Kenneth E. Sherman, Susan D. Rouster, Heidi L. Meeds, Jag H. Khalsa, Raul N. Mandler, Shenghan Lai, Marianna K. Baum
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Objective Determine if cocaine use impacts gut permeability, promotes microbial translocation and immune activation in people living with HIV (PLWH) using effective antiretroviral therapy (ART). Methods Cross-sectional analysis of 100 PLWH (ART ≥6
Externí odkaz:
https://doaj.org/article/571590f08bec4c6d9b7f11b011a8161e
Autor:
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sékaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Externí odkaz:
https://doaj.org/article/1a92cd130be447828fcd995ae89a3b10
Autor:
Simona Mutascio, Talia Mota, Lavinia Franchitti, Ashish A. Sharma, Abigail Willemse, Sydney N. Bergstresser, Hong Wang, Maura Statzu, Gregory K. Tharp, Jared Weiler, Rafick-Pierre Sékaly, Steven E. Bosinger, Mirko Paiardini, Guido Silvestri, R. Brad Jones, Deanna A. Kulpa
Publikováno v:
Immunity. 56:1132-1147.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d35dbc9ad2639db064e862cde8598ac
https://doi.org/10.1016/j.immuni.2023.03.010
https://doi.org/10.1016/j.immuni.2023.03.010
Autor:
Thomas, Hagan, Bram, Gerritsen, Lewis E, Tomalin, Slim, Fourati, Matthew P, Mulè, Daniel G, Chawla, Dmitri, Rychkov, Evan, Henrich, Helen E R, Miller, Joann, Diray-Arce, Patrick, Dunn, Audrey, Lee, Ofer, Levy, Raphael, Gottardo, Minne M, Sarwal, John S, Tsang, Mayte, Suárez-Fariñas, Rafick-Pierre, Sékaly, Steven H, Kleinstein, J S, Tsang
Publikováno v:
Nature immunology. 23(12)
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28e82f406ef6fae921fca14081dca96b
https://pubmed.ncbi.nlm.nih.gov/36443516
https://pubmed.ncbi.nlm.nih.gov/36443516
Autor:
Javier A. Tamargo, Kenneth E. Sherman, Rafick-Pierre Sékaly, Rebeka Bordi, Daniela Schlatzer, Shenghan Lai, Jag H. Khalsa, Raul N. Mandler, Richard L. Ehman, Marianna K. Baum
Publikováno v:
Drug Alcohol Depend
BACKGROUND: The simultaneous consumption of cocaine and alcohol results in the production of cocaethylene (CE) in the liver, a highly toxic metabolite. Prior research suggests that cocaine use contributes to liver disease and its concomitant use with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c262dd6933a3427777838b3c442807
https://pubmed.ncbi.nlm.nih.gov/35033954
https://pubmed.ncbi.nlm.nih.gov/35033954
Autor:
Julian H Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J Cameron, Miranda Z Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H Prince, Jennifer F Hoy, Nicolas Chomont, Rémi Fromentin, Francesco A Procopio, Joumana Zeidan, Sarah Palmer, Lina Odevall, Ricky W Johnstone, Ben P Martin, Elizabeth Sinclair, Steven G Deeks, Daria J Hazuda, Paul U Cameron, Rafick-Pierre Sékaly, Sharon R Lewin
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004473 (2014)
UnlabelledHuman immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibit
Externí odkaz:
https://doaj.org/article/b6cb4c8618164166ada773318ee06d1f
Autor:
Thomas Démoulins, Marie-Laurence Baron, Dominique Gauchat, Nadia Kettaf, Steven James Reed, Tania Charpentier, Ulrich Kalinke, Alain Lamarre, Rafi Ahmed, Rafick-Pierre Sékaly, Surojit Sarkar, Vandana Kalia
Publikováno v:
Virology. 567
Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c3877209010791b21139ce1d2ea96b
https://pubmed.ncbi.nlm.nih.gov/35032866
https://pubmed.ncbi.nlm.nih.gov/35032866
Autor:
Adam-Nicolas Pelletier, Gabriela Pacheco Sanchez, Abdullah Izmirly, Mark Watson, Tiziana Di Pucchio, Karina Inacio Carvalho, Abdelali Filali-Mouhim, Eustache Paramithiotis, Maria do Carmo S.T. Timenetsky, Alexander Roberto Precioso, Jorge Kalil, Michael S. Diamond, Elias K. Haddad, Esper G. Kallas, Rafick Pierre Sekaly
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114370- (2024)
Summary: Protective immunity to dengue virus (DENV) requires antibody response to all four serotypes. Systems vaccinology identifies a multi-OMICs pre-vaccination signature and mechanisms predictive of broad antibody responses after immunization with
Externí odkaz:
https://doaj.org/article/c2f9d70be3a14ae48b795b2d938c7d44