Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rafick P, Sékaly"'
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Oscar Blanch-Lombarte, Dan Ouchi, Esther Jimenez-Moyano, Julieta Carabelli, Miguel Angel Marin, Ruth Peña, Adam Pelletier, Aarthi Talla, Ashish Sharma, Judith Dalmau, José Ramón Santos, Rafick-Pierre Sékaly, Bonaventura Clotet, Julia G Prado
Publikováno v:
eLife, Vol 12 (2023)
The co-expression of inhibitory receptors (IRs) is a hallmark of CD8+ T-cell exhaustion (Tex) in people living with HIV-1 (PLWH). Understanding alterations of IRs expression in PLWH on long-term antiretroviral treatment (ART) remains elusive but is c
Externí odkaz:
https://doaj.org/article/212884b3996f4cf38d21dc4192521e0e
Autor:
Jacqueline Hernandez, Javier A. Tamargo, Sabrina Sales Martinez, Haley R. Martin, Adriana Campa, Rafick-Pierre Sékaly, Rebeka Bordi, Kenneth E. Sherman, Susan D. Rouster, Heidi L. Meeds, Jag H. Khalsa, Raul N. Mandler, Shenghan Lai, Marianna K. Baum
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Objective Determine if cocaine use impacts gut permeability, promotes microbial translocation and immune activation in people living with HIV (PLWH) using effective antiretroviral therapy (ART). Methods Cross-sectional analysis of 100 PLWH (ART ≥6
Externí odkaz:
https://doaj.org/article/571590f08bec4c6d9b7f11b011a8161e
Autor:
Jeffrey M Collins, Dean P Jones, Ashish Sharma, Manoj Khadka, Ken H Liu, Russell R Kempker, Brendan Prideaux, Kristal Maner-Smith, Nestani Tukvadze, N Sarita Shah, James C M Brust, Rafick-Pierre Sékaly, Neel R Gandhi, Henry M Blumberg, Eric A Ortlund, Thomas R Ziegler
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009941 (2021)
The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling
Externí odkaz:
https://doaj.org/article/5db2ee9eac9d436d93d78e7b9402b4da
Autor:
Slim Fourati, Susan Pereira Ribeiro, Filipa Blasco Tavares Pereira Lopes, Aarthi Talla, Francois Lefebvre, Mark Cameron, J. Kaewkungwal, P. Pitisuttithum, S. Nitayaphan, S. Rerks-Ngarm, Jerome H. Kim, Rasmi Thomas, Peter B. Gilbert, Georgia D. Tomaras, Richard A. Koup, Nelson L. Michael, M. Juliana McElrath, Raphael Gottardo, Rafick-Pierre Sékaly
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and i
Externí odkaz:
https://doaj.org/article/39e0d85840e44cd7872a97b96a0ffad9
Autor:
Rémi Fromentin, Sandrina DaFonseca, Cecilia T. Costiniuk, Mohamed El-Far, Francesco Andrea Procopio, Frederick M. Hecht, Rebecca Hoh, Steven G. Deeks, Daria J. Hazuda, Sharon R. Lewin, Jean-Pierre Routy, Rafick-Pierre Sékaly, Nicolas Chomont
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates l
Externí odkaz:
https://doaj.org/article/e996a4e085b845f09a6cdde3b15c9886
Autor:
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sékaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Externí odkaz:
https://doaj.org/article/1a92cd130be447828fcd995ae89a3b10
Autor:
Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepat
Externí odkaz:
https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
Autor:
Francesco Andrea Procopio, Rémi Fromentin, Deanna A. Kulpa, Jessica H. Brehm, Anne-Gaelle Bebin, Matthew C. Strain, Douglas D. Richman, Una O'Doherty, Sarah Palmer, Frederick M. Hecht, Rebecca Hoh, Richard J.O. Barnard, Michael D. Miller, Daria J. Hazuda, Steven G. Deeks, Rafick-Pierre Sékaly, Nicolas Chomont
Publikováno v:
EBioMedicine, Vol 2, Iss 8, Pp 874-883 (2015)
Background: Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low frequency of these cells makes this very challenging. Methods: We
Externí odkaz:
https://doaj.org/article/2e7bfa284a9f4d7b88f06a8f37a05e38
Autor:
Christina Gavegnano, Jessica H Brehm, Franck P Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J Hurwitz, Vincent C Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F Schinazi, Rafick Pierre Sékaly
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006740 (2017)
Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir establishment, maintenance, and expansion, remains a challenge. T cell homeostasis is a major drive
Externí odkaz:
https://doaj.org/article/4317a5f5021746d493577bcfb4b68481