Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Raffaello Giorgi"'
Autor:
Raffaello Giorgi, Stefania Santeusanio, Orazio A. Attanasi, Francesca R. Perrulli, Ada Perrone, Susanna Monti, Anna Rita Renzetti, Lucia De Crescentini, Spartaco Mauro Colombani
Publikováno v:
Il Farmaco. 54:64-76
Based on preliminary molecular modelling study, the synthesis of two different classes of biphenylyltetrazole derivatives of 1-aminopyrroles, as potentially active non-peptide angiotensin II (AII) antagonists, is reported. Some NH -Boc protected 1-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90e91f1b4ed531ce03fb4a6fbc1104d
https://doi.org/10.1016/s0014-827x(98)00100-1
https://doi.org/10.1016/s0014-827x(98)00100-1
Autor:
Raffaello Giorgi, Bonaccorsi Fabrizio
Publikováno v:
Synthetic Communications. 27:1143-1147
Synthetically useful O-benzylhydroxylamine can be conveniently prepared in large scale by reaction of N-hydroxyphthalimide and benzyl chloride in phase transfer conditions, followed by acidic hydrolysis of N-benzyloxyphthalimide. The overall yield is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccd315dc8e06301c6def54be581c5a6
https://doi.org/10.1080/00397919708003349
https://doi.org/10.1080/00397919708003349
Autor:
Francesca R. Perrulli, Giuseppe Gatti, Stefania Santeusanio, Orazio A. Attanasi, Elisabetta Foresti, Raffaello Giorgi, Lucia De Crescentini
Publikováno v:
Scopus-Elsevier
1-NH-BOC protected 1,2-diaminopyrroles have been converted by one-pot cleavage of the protecting group and subsequent reaction of the compounds obtained with 1,2-dicarbonyl compounds into highly substituted pyrrolo[1,2-b][1,2,4]triazines. Structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6ed2e4069f3f0b09b3280bf4f318b2
https://doi.org/10.1039/a700355b
https://doi.org/10.1039/a700355b
Autor:
Paolo Dapporto, Spartaco Mauro Colombani, Giorgio Garzelli, Raffaello Giorgi, Alessandro Subissi, Paola Paoli, Luigi Turbanti, Cristina Di Bugno
Publikováno v:
Chirality. 9:713-721
The compound [2-(1-diethylaminopropyl)] 1-hydroxy-1,1′-bicyclohexyl-2-carboxylate 1 is a muscarinic antagonist characterized by the presence of three chiral atoms and eight possible stereoisomers. The binding affinities to the five cloned m1–m5 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29c6b271c9d89fb54133227da9d09fe
https://doi.org/10.1002/(sici)1520-636x(1997)9:8<713::aid-chir1>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1997)9:8<713::aid-chir1>3.0.co
Autor:
Carlo Rosini, Dario Pini, Antonella Petri, Cristina Di Bugno, Luigi Turbanti, Fabio Marchetti, Piero Salvadori, Raffaello Giorgi
Publikováno v:
Tetrahedron. 50:205-216
A study of the C.D. spectrum of a derivative of cis-(+)-2-hydroxy-2-phenylcyclohexanecarboxyclic acid has been achieved, providing a useful method for establishing the C1 and C2 absolute configuration of this compound.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a00ca260cdb7cc62e6fa2491fcfcb23
https://doi.org/10.1016/s0040-4020(01)80746-8
https://doi.org/10.1016/s0040-4020(01)80746-8
Autor:
Paolo Dapporto, Alessandro Subissi, Paola Paoli, Federico Arcamone, Cristina Di Bugno, Raffaello Giorgi, Stefano Manzini
Publikováno v:
Scopus-Elsevier
The enantiomers of 1-methyl-3-(10H-phenothiazine-10-ylmethyl)-1-azoniabicyclo[2,2,2]octane iodide (1) were prepared by chiral chromatographic resolution of the precursor mequitazine (2). The (+)-(S)-enantiomer 1b is 10-fold more potent than (−)-(R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05f0b31642e941425d6500f8cccfab6
https://doi.org/10.1002/chir.530060505
https://doi.org/10.1002/chir.530060505
Autor:
Raffaello Giorgi, Bonaccorsi Fabrizio
Publikováno v:
ChemInform. 28
Synthetically useful O-benzylhydroxylamine can be conveniently prepared in large scale by reaction of N-hydroxyphthalimide and benzyl chloride in phase transfer conditions, followed by acidic hydrolysis of N-benzyloxyphthalimide. The overall yield is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c8a6cb25f0e552bf5b9c153c81da76
https://doi.org/10.1002/chin.199728070
https://doi.org/10.1002/chin.199728070
Autor:
Ada Perrone, Francesca R. Perrulli, Raffaello Giorgi, Susanna Monti, Stefania Santeusanio, Lucia De Crescentini, Anna Rita Renzetti, Orazio A. Attanasi, Spartaco Mauro Colombani
Publikováno v:
ChemInform. 30
Based on preliminary molecular modelling study, the synthesis of two different classes of biphenylyltetrazole derivatives of 1-aminopyrroles, as potentially active non-peptide angiotensin II (AII) antagonists, is reported. Some NH -Boc protected 1-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a7e9716bd408bed0dcd4d52ffeaa173
https://doi.org/10.1002/chin.199932128
https://doi.org/10.1002/chin.199932128
Autor:
Cristina Di Bugno, Annalisa Lippi, Raffaello Giorgi, Alessandro Subissi, Susanna Monti, Nicholas J. S. Harmat, Marco Criscuoli, Adriano Martinelli
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(10)
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1436975a1427c230e098fa17d7e526e
https://pubmed.ncbi.nlm.nih.gov/9871744
https://pubmed.ncbi.nlm.nih.gov/9871744
Autor:
Cristina Di Bugno, Giorgio Catelani, Ettore Mastrorilli, Raffaello Giorgi, Valeria Di Bussolo
(±)-1-Cyclohexyl- c -2-hydroxymethyl- r -1-cyclohexanol 3 , a precursor of the antimuscarinic drug Rociverine 1 , was obtained diastereospecifically in very high yield, from the Grignard reaction between C 6 H 11 MgCl and an appropriately protected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22966b3be6407c70ec748e2d607de95
http://hdl.handle.net/11568/176085
http://hdl.handle.net/11568/176085
