Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Raffaella Sordella"'
Autor:
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Publikováno v:
eLife, Vol 10 (2021)
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of trea
Externí odkaz:
https://doaj.org/article/8f753d647a7d4f28ad16d9538172ef03
Autor:
Serif Senturk, Nitin H. Shirole, Dawid G. Nowak, Vincenzo Corbo, Debjani Pal, Alexander Vaughan, David A. Tuveson, Lloyd C. Trotman, Justin B. Kinney, Raffaella Sordella
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturket al. develop an inducible editing system by fusing a conditional destabilization domain to Cas9 and demonstrate temporal control of gene editing in response to
Externí odkaz:
https://doaj.org/article/12bf0bf4ae954de9832a7c856f71605e
Autor:
Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/f2b4618c51e34ff391898364f003aa4b
Autor:
Debjani Pal, Anja Pertot, Nitin H Shirole, Zhan Yao, Naishitha Anaparthy, Tyler Garvin, Hilary Cox, Kenneth Chang, Fred Rollins, Jude Kendall, Leyla Edwards, Vijay A Singh, Gary C Stone, Michael C Schatz, James Hicks, Gregory J Hannon, Raffaella Sordella
Publikováno v:
eLife, Vol 6 (2017)
Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanism
Externí odkaz:
https://doaj.org/article/b7f989bbb5ea4d239de1e7c89e4b0fc4
Autor:
Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella
Publikováno v:
eLife, Vol 5 (2016)
TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p53 tumor su
Externí odkaz:
https://doaj.org/article/0ca2ccc471344a649b1d2de0b77d056c
Autor:
Danilo Segovia, Daniel Ramirez, Sania Jevtic, Raffaella Sordella, Scott K. Lyons, Polona Safaric Tepes
Publikováno v:
Laboratory Investigation. 102:1038-1049
Mesenchymal chondrosarcoma (MCS) is a high-grade malignancy that represents 2-9% of chondrosarcomas and mostly affects children and young adults. HEY1-NCoA2 gene fusion is considered to be a driver of tumorigenesis and it has been identified in 80% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8daff5c36e40044120b2f1f95de5bba3
https://doi.org/10.1038/s41374-021-00704-4
https://doi.org/10.1038/s41374-021-00704-4
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S2. Genetic tools used for dissecting Il6/Stat3/Myc signaling. (A) Scheme of conditional alleles and PCR primers used for assessing the recombination of Pten/ Trp53 genes. (B) Senescence-specific ß-gal staining is detected aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3752ff135b1299d84053c6e9105cff5a
https://doi.org/10.1158/2159-8290.22531532
https://doi.org/10.1158/2159-8290.22531532
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S1. Copy Number Alteration analysis of human prostate cancer confirms loss of PTEN and TP53 genes as a genetic hallmark of metastatic prostate cancer. (A) Co-deletion frequency for PTEN and TP53 in metastatic and primary prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22326194e1055bee8ad81bfb6aeb82
https://doi.org/10.1158/2159-8290.22531538.v1
https://doi.org/10.1158/2159-8290.22531538.v1
Autor:
Timothy E. McGraw, Nasser K. Altorki, Olivier Elemento, Brendon M. Stiles, Robert Mohney, Edward D. Karoly, Raffaella Sordella, Melanie S. Buckman, Salihah A. Dick, Gregory G. Salzler, Virendra K. Chaudhri
PDF file - 403K, Supplemental Figure 1. Heat map of 203 metabolites in 21 pairs of CAFs and NFs. Supplemental Figure 2. The distributions of "relative" t-scores for the 203 metabolites categorized into 46 biochemical subgroupings. Supplemental Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2022de117eca7a96bb2138d5b8ff0cda
https://doi.org/10.1158/1541-7786.22516531
https://doi.org/10.1158/1541-7786.22516531
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S7. Pathway to Pten/ Trp53 deficient prostate metastasis and therapy resistance. Pten-loss triggers PIP3 signaling to activate AKT, which prompts activation of the p53/ p21/ p16 tumor suppressors and senescence arrest. Suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc22895428a5ce3e29b0e0edd7fff7
https://doi.org/10.1158/2159-8290.22531517
https://doi.org/10.1158/2159-8290.22531517