Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Raffaella Nannei"'
Autor:
Valentina Zuco, Michelandrea De Cesare, Raffaella Cincinelli, Raffaella Nannei, Claudio Pisano, Nadia Zaffaroni, Franco Zunino
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29085 (2011)
Preclinical studies support the therapeutic potential of histone deacetylases inhibitors (HDACi) in combination with taxanes. The efficacy of combination has been mainly ascribed to a cooperative effect on microtubule stabilization following tubulin
Externí odkaz:
https://doaj.org/article/c37bf4752e0f4e52ada7ab27bd21ba8b
Autor:
Lucio Merlini, Leonardo Scaglioni, Raffaella Cincinelli, Raffaella Nannei, Sabrina Dallavalle
Publikováno v:
Tetrahedron. 65:3465-3472
Acid treatment of indole-2-carboxylic acid β- and γ-oxoamides causes Friedel–Crafts intramolecular cyclization to β-carbolinones and dihydro-2 H -azepino[3,4- b ]indol-1-ones, in contrast to secondary δ-,ɛ-, and ζ-oxoamides, which cyclize to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b97b68200699b91ab23b6bf0188f00c
https://doi.org/10.1016/j.tet.2009.02.036
https://doi.org/10.1016/j.tet.2009.02.036
Autor:
Raffaella Cincinelli, Sabrina Dallavalle, Giuliana Cassinelli, Giuditta Cuccuru, Raffaella Nannei, Cinzia Lanzi, Eleonora Rizzi, Franco Zunino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3962-3968
A novel series of 3-arylureidobenzylidene-indolin-2-ones was synthesized and their inhibitory activity against Ret tyrosine kinase investigated in comparison with the Ret inhibitor RPI-1 as a reference compound for this series. A few compounds were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb634ddbe61d9a6d376b419c972f7398
https://doi.org/10.1016/j.bmcl.2007.04.091
https://doi.org/10.1016/j.bmcl.2007.04.091
Autor:
Giuseppe Giannini, Daniele De Zani, Lucio Merlini, Sabrina Dallavalle, Franco Zunino, Raffaella Cincinelli, Chiara Zanchi, Serena Carella, Valentina Zuco, Enrico Garattini, Raffaella Nannei, Sergio Penco, Paolo Carminati, Claudio Pisano, Loredana Vesci
Publikováno v:
Journal of Medicinal Chemistry. 48:4931-4946
Atypical retinoids (AR) represent a class of proapoptotic agents with promising potential in the treatment of neoplastic diseases. In the present work 4'-hydroxybiphenyl-4-ylacrylic acids were studied as a novel series of AR. The synthesized compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057f7a5921b1bcb9383d08f7acdc4063
https://doi.org/10.1021/jm049440h
https://doi.org/10.1021/jm049440h
Publikováno v:
Synlett. :2676-2678
A synthetic approach to sporotricale methylether, a metabolite of the fungus Sporotrichum laxum with inhibitory activity against Helicobacter pylori, is described. The synthesis relies on the condensation of 13-hydroxy-10-oxotetradecanal, prepared vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a994737af266a313eee34ed12eabc4
https://doi.org/10.1055/s-2005-917096
https://doi.org/10.1055/s-2005-917096
Autor:
Tiziana Brunetti, Claudio Pisano, Federica Bucci, Gianfranco Battistuzzi, Gianandrea Quattrociocchi, Rosanna Foderà, Mario B. Guglielmi, Raffaella Nannei, Lucio Merlini, Loredana Vesci, Maria Grazia Cima, Giuseppe Giannini, Domenico Alloatti, Raffaella Cincinelli, Walter Cabri, Sabrina Dallavalle
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb170a3c854629de932bd0269c59ab72
http://hdl.handle.net/11585/756784
http://hdl.handle.net/11585/756784
Autor:
Franco Zunino, Raffaella Nannei, Raffaella Cincinelli, Claudio Pisano, Michelandrea De Cesare, Valentina Zuco, Nadia Zaffaroni
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29085 (2011)
PLoS ONE
PLoS ONE
Preclinical studies support the therapeutic potential of histone deacetylases inhibitors (HDACi) in combination with taxanes. The efficacy of combination has been mainly ascribed to a cooperative effect on microtubule stabilization following tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7f5cff27fb3ffbc9f7ae21c68bca36
http://europepmc.org/articles/PMC3241602?pdf=render
http://europepmc.org/articles/PMC3241602?pdf=render
Autor:
Raffaella Nannei, Lucio Merlini, Patrizia Minetti, Sergio Penco, Chiara De Simone, Mauro Maccarrone, Gianandrea Quattrociocchi, Filomena Fezza, Sabrina Dallavalle, Natalia Battista, Walter Cabri, Franco Borsini, Sonia Gattinoni, Antonio Caprioli
A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, rever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c81fa374e2c5c9d7ad88ab446fd8f3
http://hdl.handle.net/2108/39186
http://hdl.handle.net/2108/39186
Autor:
Franco Borsini, Filomena Fezza, Sabrina Dallavalle, Gianandrea Quattrociocchi, Walter Cabri, Lucio Merlini, Daniele Amadio, Antonio Caprioli, Sonia Gattinoni, Mauro Maccarrone, Chiara De Simone, Raffaella Nannei, Sergio Penco, Patrizia Minetti
FAAH inhibitors: This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of the endocannabinoid system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f5074b7fa3fe4aab5893b86af0fb0b
http://hdl.handle.net/11585/756804
http://hdl.handle.net/11585/756804
Autor:
Loredana Vesci, Lucio Merlini, Gabriella Morini, Claudio Pisano, Michelandrea De Cesare, Franco Zunino, Raffaella Nannei, Sergio Penco, Raffaella Cincinelli, Sabrina Dallavalle, Valentina Zuco, Marcella Barbarino
Publikováno v:
European journal of medicinal chemistry. 44(5)
A series of hydroxamic acid-based histone deacetylase (HDAC) inhibitors were designed on the basis of a model of the HDAC2 binding site and synthesized. They are characterized by a cinnamic spacer, capped with a substituted phenyl group. Modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07050a96011b6fb71127530ddbf47179
https://pubmed.ncbi.nlm.nih.gov/19084294
https://pubmed.ncbi.nlm.nih.gov/19084294