Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Raffaella Mangano"'
Autor:
Gordon C Jayson, Gary Acton, Jonathan A. Ledermann, Geoff Hall, Sarah Halford, Martin Highley, Nicola J. Curtin, Ruth Plummer, Julieann Sludden, R.M. Glasspool, David Jamieson, Alan V. Boddy, Zoe Backholer, Daniel Rea, Raffaella Mangano, Yvette Drew, James W. Murray
Publikováno v:
British Journal of Cancer
Drew, Y, Ledermann, J, Hall, G, Rea, D, Glasspool, R, Highley, M, Jayson, G, Sludden, J, Murray, J, Jamieson, D, Halford, S, Acton, G, Blackholer, Z, Mangano, R, Boddy, A, Curtin, N & Plummer, R 2016, ' Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer ', Br J Cancer, vol. 114, e21 . https://doi.org/10.1038/bjc.2016.41
Drew, Y, Ledermann, J, Hall, G, Rea, D, Glasspool, R, Highley, M, Jayson, G, Sludden, J, Murray, J, Jamieson, D, Halford, S, Acton, G, Blackholer, Z, Mangano, R, Boddy, A, Curtin, N & Plummer, R 2016, ' Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer ', Br J Cancer, vol. 114, e21 . https://doi.org/10.1038/bjc.2016.41
Background: Rucaparib is an orally available potent selective small-molecule inhibitor of poly(ADP-ribose) polymerase (PARP) 1 and 2. Rucaparib induces synthetic lethality in cancer cells defective in the homologous recombination repair pathway inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5e00f287a35b93593ae9c8ca970c12
https://hdl.handle.net/11541.2/133063
https://hdl.handle.net/11541.2/133063
Autor:
Gill Matthew Iain Andrew, Nigel Ramsden, Steve Price, Christopher Higgs, Richard Hale, Dennis Norman, Dan Leggate, Hazel Joan Dyke, Soraya S. Porres, Raffaella Mangano, Pascal Savy, Alison Jones, Francis Xavier Wilson, Peter Lockey, Neil Jennings, David E. Clark, Sue Cramp, Marie Andersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2516-2519
The identification and hit-to-lead exploration of a novel, potent and selective series of histamine H4 receptor inverse agonists is described. The initial hit, 3A (IC50 19 nM) was identified by means of a ligand-based virtual screening approach. Subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd703160124379248489a945072de4a
https://doi.org/10.1016/j.bmcl.2010.02.097
https://doi.org/10.1016/j.bmcl.2010.02.097
Autor:
Jana Kretzschmar, Giulio Superti-Furga, Stefania Gonfloni, Marina Moro, Raffaella Mangano, Daniela Barilà, Dirk Bohmann
Publikováno v:
Scopus-Elsevier
The nuclear function of the c-Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736143d9198e8468029df5aae9ee037e
https://doi.org/10.1093/emboj/19.2.273
https://doi.org/10.1093/emboj/19.2.273
Autor:
Salvatore Feo, Mike Fried, Raffaella Mangano, Trevor Duhig, Eugenia Piddini, Letizia Carramusa
Publikováno v:
Oncogene. 17:2771-2777
The major amplicon present in HL60 cells is chimeric in nature being composed of 70 kb of DNA sequence derived from the MYC locus linked to 80 kb of novel DNA sequence derived from a non contiguous region located telomeric to the c-myc gene at 8q24 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb3dcb93f3e982663c20ba2e2ef5df
https://doi.org/10.1038/sj.onc.1202434
https://doi.org/10.1038/sj.onc.1202434
Autor:
Paolo Albani, Arianna Ascenzi, Bozzarelli, Oriana, Maurizio, Caminito, Cecilia, Cognigni, Davide, Dalmas, Giulia Del Vecchio, Roberto Di Carlo, Valentina, Esposito, Chiara, Faggiolani, Giulio, Fortunio, Anna, Galluzzi, Giorgio, Gazzera, Anna La Ferla, Raffaella, Mangano, Beatrice, Manetti, Sara, Marchisio, Carlotta, Margarone, Luisa, Marquartdt, Marco, Muscogiuri, Enrica Pagella, Caterina Ramonda, Claudio, Rosati, Michele, Santoro, Franca, Varallo, Maurizio, Vivarelli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______970::987d8966a19a7604382d41e1a727315e
http://hdl.handle.net/2318/1533738
http://hdl.handle.net/2318/1533738
Autor:
Katie Ellard, Marcus Bantscheff, Satoko Shimamura, Kathryn Bell, Carsten Hopf, Faiza Rharbaoui, Nigel Ramsden, Mikhail M. Savitski, Gerard Drewes, Gitte Neubauer, Raffaella Mangano, Andrew Cansfield, Toby Mathieson, Ivan Plavec, Christina Rau, Friedrich B M Reinhard, Daniel Leggate, Alison O'Mahony, Thilo Werner, Carola Doce, Jessica Perrin, Katrin Müller, Giovanna Bergamini, Oliver Rausch, Emilio Hirsch
Publikováno v:
Nature chemical biology. 8(6)
We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC24832, which is to our knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b747e5342fff30edde4865e7369029c5
https://pubmed.ncbi.nlm.nih.gov/22544264
https://pubmed.ncbi.nlm.nih.gov/22544264
Autor:
Bettina Huhse, Heinz Ruffner, Judith Schlegl, Karen Croughton, Anne-Claude Gavin, Martin Stein, Jens Rick, Georg Casari, Markus Schirle, Tewis Bouwmeester, Sonja Ghidelli, Bernhard Kuster, David B. Jackson, Gitte Neubauer, Giulio Superti-Furga, Raffaella Mangano, Giovanna Bergamini, Gerard Joberty, Dirk Eberhard, Markus Schwab, Angela Bauch, Pierre-Olivier Angrand, Julien Gagneur, Cristina Cruciat, Carsten Hopf, Anne-Marie Michon, Gerard Drewes, Andreas Bauer
Publikováno v:
Nature cell biology, Vol. 6, No 2 (2004) pp. 97-105
Signal transduction pathways are modular composites of functionally interdependent sets of proteins that act in a coordinated fashion to transform environmental information into a phenotypic response. The pro-inflammatory cytokine tumour necrosis fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e36d31771c1614952c5b59fbbe1f3de
https://archive-ouverte.unige.ch/unige:157148
https://archive-ouverte.unige.ch/unige:157148
Tyrosine phosphorylation is usually associated with cytoplasmic events. Yet, over the years, many reports have accumulated on tyrosine phosphorylation of individual molecules in the nucleus, and several tyrosine kinases and phosphatases have been fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ddbae7a39078a1ed66daaa8518822
http://hdl.handle.net/2108/10561
http://hdl.handle.net/2108/10561
Autor:
Carola Doce, Friedrich B M Reinhard, Thilo Werner, Raffaella Mangano, Satoko Shimamura, Katrin Müller, Nigel Ramsden, Gerard Drewes, Daniel Leggate, Gitte Neubauer, Jessica Perrin, Toby Mathieson, Alison O'Mahony, Marcus Bantscheff, Andrew Cansfield, Faiza Rharbaoui, Kathryn Bell, Carsten Hopf, Oliver Rausch, Mikhail M. Savitski, Ivan Plavec, Christina Rau, Katie Ellard, Giovanna Bergamini, Emilio Hirsch
Publikováno v:
Nature Chemical Biology. 8:737-737
Nat. Chem. Biol. 8, 576–582 (2012); published online 29 April 2012; corrected after print 16 May 2012 In the version of this article initially published, the name M. Sunose was misspelled in the Acknowledgements. The error has been corrected in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c6db21d6695aadcb73d0425a7c3a4c
https://doi.org/10.1038/nchembio0812-737b
https://doi.org/10.1038/nchembio0812-737b
Autor:
Adele Rowley, Pierre-Olivier Angrand, Martin Stein, Eithne O'Sullivan, Jyoti S. Choudhary, Susie Thomas, Pamela Völkel, Brian Heffernan, Bernhard Kuster, Julien Gagneur, Gerard Drewes, Heinz Ruffner, Carsten Hopf, Lisa Pickard, Raffaella Mangano
Publikováno v:
Neurobiology of Aging. 25:S37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcaf4117595b8bb41e604ccb6dcdc599
https://doi.org/10.1016/s0197-4580(04)80123-4
https://doi.org/10.1016/s0197-4580(04)80123-4