Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Raffaella Liccardo"'
Autor:
Antonio Nolano, Giovanni Battista Rossi, Valentina D’Angelo, Raffaella Liccardo, Marina De Rosa, Paola Izzo, Francesca Duraturo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5970 (2023)
Lynch syndrome (LS) is an autosomal dominant inherited disorder that primarily predisposes individuals to colorectal and endometrial cancer. It is associated with pathogenic variants in DNA mismatch repair (MMR) genes. In this study, we report the ca
Externí odkaz:
https://doaj.org/article/05884fb15f4c47ac9c0938428d56c91b
Autor:
Raffaella Liccardo, Antonio Nolano, Matilde Lambiase, Carlo Della Ragione, Marina De Rosa, Paola Izzo, Francesca Duraturo
Publikováno v:
Biomedicines, Vol 8, Iss 6, p 167 (2020)
Background: The loss or low expression of DNA mismatch repair (MMR) genes can result in genomic instability and tumorigenesis. One such gene, MSH2, is mutated or rearranged in Lynch syndrome (LS), which is characterized by a high risk of tumor develo
Externí odkaz:
https://doaj.org/article/8e3539812d24414682a2470e060731cf
Publikováno v:
Clinical Medicine Insights: Case Reports, Vol 11 (2018)
Lynch syndrome is an autosomal dominant syndrome that can be subdivided into Lynch syndrome I, or site-specific colonic cancer, and Lynch syndrome II, or extracolonic cancers, particularly carcinomas of the stomach, endometrium, biliary and pancreati
Externí odkaz:
https://doaj.org/article/efcea0f099284458a941acaae7f844a4
Publikováno v:
Gastroenterology Research and Practice, Vol 2017 (2017)
About 10% of total colorectal cancers are associated with known Mendelian inheritance, as Familial Adenomatous Polyposis (FAP) and Lynch syndrome (LS). In these cancer types the clinical manifestations of disease are due to mutations in high-risk all
Externí odkaz:
https://doaj.org/article/1e6abf17255b4662b3dd22caf9d7be3c
Autor:
Raffaella Liccardo, Matilde Lambiase, Antonio Nolano, Marina De Rosa, Paola Izzo, Francesca Duraturo
Publikováno v:
International journal of molecular medicine. 49(6)
The molecular characterization of patients with Lynch syndrome (LS) involves germline testing to detect a deleterious mutation in one of the genes of the mismatch repair (
Autor:
Antonio Nolano, Alessia Medugno, Silvia Trombetti, Raffaella Liccardo, Marina De Rosa, Paola Izzo, Francesca Duraturo
Publikováno v:
Cancers. 15:75
Hereditary non-polyposis colorectal cancer is also known as Lynch syndrome. Lynch syndrome is associated with pathogenetic variants in one of the mismatch repair (MMR) genes. In addition to colorectal cancer, the inefficiency of the MMR system leads
Autor:
Raffaella, Liccardo, Raffaele, Sessa, Silvia, Trombetti, Marina, De Rosa, Paola, Izzo, Michela, Grosso, Francesca, Duraturo
Publikováno v:
Cancers
Simple Summary In a previous study, we identified a patient carrying the variant c.*226A>G in the MSH2 3′ untranslated region that showed overexpression of MSH2 protein. In this study, we hypothesized that the MSH2 3′UTR contained a seed region f
Autor:
Carlo Della Ragione, Marina De Rosa, Nunzio Mitilini, Paola Izzo, Francesca Duraturo, Raffaella Liccardo
Publikováno v:
Cancer Management and Research. 11:6719-6725
Background: Lynch syndrome is associated with genetic variants in mismatch repair (MMR) genes. Pathogenic variants in the MLH1 and MSH2 genes occur in most families in which the phenotype is highly penetrant. These testing criteria are likely to miss
Autor:
Paola Izzo, Francesca Duraturo, Michela Grosso, Marina De Rosa, Silvia Trombetti, Raffaele Sessa, Raffaella Liccardo
Publikováno v:
Cancers, Vol 13, Iss 4662, p 4662 (2021)
Cancers
Volume 13
Issue 18
Cancers
Volume 13
Issue 18
Mismatch Repair (MMR) gene dysregulation plays a fundamental role in Lynch Syndrome (LS) pathogenesis, a form of hereditary colorectal cancer. Loss or overexpression of key MMR genes leads to genome instability and tumorigenesis
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1605770ba29ea6df129a0dea69ce2eb
http://hdl.handle.net/11588/873539
http://hdl.handle.net/11588/873539
Autor:
Andrea Cerasuolo, Marina De Rosa, Erasmo Miele, Paola Izzo, Antonietta Aversano, Raffaella Liccardo, Francesca Duraturo, Francesca Cammarota, Marina Russo
Publikováno v:
Mol Clin Oncol
Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary precancerous condition caused by germline pathogenetic variants in the tumor suppressor adenomatous polyposis coli (APC) gene. Patients with FAP develop multiple gastrointestina