Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Raffaella Defferrari"'
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Akademický článek
The p53 Codon 72 Pro/Pro Genotype Identifies Poor-Prognosis Neuroblastoma Patients: Correlation with Reduced Apoptosis and Enhanced Senescence by the p53-72P Isoform
Autor: Sara Cattelani, Giovanna Ferrari-Amorotti, Sara Galavotti, Raffaella Defferrari, Barbara Tanno, Samantha Cialfi, Jenny Vergalli, Valentina Fragliasso, Clara Guerzoni, Gloria Manzotti, Angela Rachele Soliera, Chiara Menin, Roberta Bertorelle, Heather P. McDowell, Alessandro Inserra, Maria Luisa Belli, Luigi Varesio, Deborah Tweddle, Gian Paolo Tonini, Pierluigi Altavista, Carlo Dominici, Giuseppe Raschellà, Bruno Calabretta
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 7, Pp 634-643 (2012)
The p53 gene is rarely mutated in neuroblastoma, but codon 72 polymorphism that modulates its proapoptotic activity might influence cancer risk and clinical outcome. We investigated whether this polymorphism affects neuroblastoma risk and disease out
Externí odkaz: https://doaj.org/article/a82fdf1e4a494fedb36b4d5a5686f82e
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2
Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
Autor: Rosa Noguera, Peter F. Ambros, Carole Coze, Dominik Bogen, Katia Mazzocco, Raffaella Defferrari, Klaus Beiske, Vassilios Papadakis, Gabriele Amann, Ellen Ruud, Angela Rita Sementa, Inge M. Ambros, Luigi Varesio, Valérie Combaret, Samuel Navarro, Victoria Castel, Ana P. Berbegall, Marta Jeison, Ruth Ladenstein, Nick Bown, Cormac Owens, Ulrike Pötschger, Ales Vicha, Shifra Ash
Publikováno v: BRITISH JOURNAL OF CANCER
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
British Journal of Cancer
Background In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885658426a76bef79c7bae3ea38795a9
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2502
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3
Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients
Autor: Rogier Versteeg, Wendy B. London, Valérie Combaret, Jan Koster, Rosa Noguera, Gudrun Schleiermacher, Toby Dylan Hocking, Julie R. Park, Matthias Fischer, Edward F. Attiyeh, Michael D. Hogarty, Genevieve Laureys, Katleen De Preter, Miki Ohira, Pauline Depuydt, Ruth Ladenstein, Franki Speleman, Gian Paolo Tonini, Jessica Theissen, Peter F. Ambros, Raffaella Defferrari, Shahab Asgharzadeh, Akira Nakagawara, Valentina Boeva, Luigi Varesio, Ulrike Pötschger, Barbara Hero, Inge M. Ambros, John M. Maris, Eve Lapouble, Robrecht Cannoodt, Katia Mazzocco, Dominique Valteau-Couanet, Susan G. Kreissman, Meredith S. Irwin
Publikováno v: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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JNCI Journal of the National Cancer Institute
Journal of the National Cancer Institute, 110(10), 1084-1093. Oxford University Press
Background Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2c2b5a17bb88b02bd4fba4df021cd9
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1708
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5
Constitutional 3p26.3 terminal microdeletion in an adolescent with neuroblastoma
Autor: Vito Pistoia, Margherita Lerone, Anna Rita Gigliotti, Angela Rita Sementa, Martina Morini, Luigi Varesio, Alberto Garaventa, Annalisa Pezzolo, Raffaella Defferrari, Marzia Ognibene, Massimo Conte, Katia Mazzocco
Publikováno v: Cancer biologytherapy. 18(5)
Background: Neuroblastoma (NB) is a common and often lethal cancer of early childhood that accounts for 10% of pediatric cancer mortality. Incidence peaks in infancy and then rapidly declines, with less than 5% of cases diagnosed in children and adol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36ffa01fbe9b975e5ebbbe45ae8f938
https://pubmed.ncbi.nlm.nih.gov/28402723
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6
Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification
Autor: Valérie Combaret, A. Valent, Bárbara Marques, Ales Vicha, Tommy Martinsson, N. Van Roy, Riccardo Haupt, Gian Paolo Tonini, Gudrun Schleiermacher, Alberto Garaventa, M. Jeison, Stefano Parodi, Peter F. Ambros, Claudio Gambini, Giovanni Erminio, J.A. Kohler, I.M. Ambros, Nicole Gross, John Lunec, Raffaella Defferrari, Rosa Noguera, Ana P. Berbegall, Jérôme Couturier, Clare Bedwell, Deborah A. Tweddle, Klaus Beiske, Jean Bénard, Eva Villamón, Katia Mazzocco, Nick Bown
Publikováno v: BRITISH JOURNAL OF CANCER
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
British Journal of Cancer, vol. 112, no. 2, pp. 290-295
British Journal of Cancer
British Journal of Cancer 112 (2015): 290–295. doi:10.1038/bjc.2014.557
info:cnr-pdr/source/autori:Defferrari R, Mazzocco K, Ambros IM, Ambros PF, Bedwell C, Beiske K, Bénard J, Berbegall AP, Bown N, Combaret V, Couturier J, Erminio G, Gambini C, Garaventa A, Gross N, Haupt R, Kohler J, Jeison M, Lunec J, Marques B, Martinsson T, Noguera R, Parodi S, Schleiermacher G, Tweddle DA, Valent A, Van Roy N, Vicha A, Villamon E, Tonini GP./titolo:Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification./doi:10.1038%2Fbjc.2014.557/rivista:British Journal of Cancer/anno:2015/pagina_da:290/pagina_a:295/intervallo_pagine:290–295/volume:112
Background: The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cab5a88345e777e64001e14240459b4
https://doi.org/10.1038/bjc.2014.557
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7
Piloting the European Unified Patient Identity Management (EUPID) Concept to Facilitate Secondary Use of Neuroblastoma Data from Clinical Trials and Biobanking
Autor: Hubert, Ebner, Dieter, Hayn, Markus, Falgenhauer, Michael, Nitzlnader, Gudrun, Schleiermacher, Riccardo, Haupt, Giovanni, Erminio, Raffaella, Defferrari, Katia, Mazzocco, Jan, Kohler, Gian Paolo, Tonini, Ruth, Ladenstein, Guenter, Schreier
Publikováno v: Studies in health technology and informatics. 223
Data from two contexts, i.e. the European Unresectable Neuroblastoma (EUNB) clinical trial and results from comparative genomic hybridisation (CGH) analyses from corresponding tumour samples shall be provided to existing repositories for secondary us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec06eadab9b3d9e70a9ca906f1de654a
https://pubmed.ncbi.nlm.nih.gov/27139382
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8
MDM2 SNP309 genotype is associated with ferritin and LDH serum levels in children with stage 4 neuroblastoma
Autor: Gilberto Fronza, Riccardo Haupt, Gian Paolo Tonini, Stefano Parodi, Alberto Inga, Raffaella Defferrari, Alberto Garaventa, Chiara Perfumo, Katia Mazzocco
Publikováno v: Pediatric Blood & Cancer. 55:267-272
Background MDM2 SNP309, characterised by a T-to-G substitution in the MDM2 promoter, is associated with higher gene expression compared to wild type and was recently found to be a negative prognostic factor for patients with stage 4 neuroblastoma (NB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::661b6b9b4bf135fe66a7fcc78346583a
https://doi.org/10.1002/pbc.22477
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9
Competition between recipient and donor cells after bone marrow transplantation for chronic myeloid leukaemia
Autor: Andrea Bacigalupo, Alberto M. Marmont, Francesco Frassoni, Repetto M, Mario Sessarego, Paolo Strada, Raffaella Defferrari, Domenico Occhini, Salvatore Miceli
Publikováno v: British Journal of Haematology. 69:471-475
The cytogenetic and clinical course of three patients allografted for Ph positive chronic myeloid leukaemia are reported. All patients had a peculiar pattern of relapse. Two out of three patients had donor marrow graft pretreated with monoclonal anti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668f9032796c3c0e7459445afb47a692
https://doi.org/10.1111/j.1365-2141.1988.00449.x-i1
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10
Genome analysis and gene expression profiling of neuroblastoma and ganglioneuroblastoma reveal differences between neuroblastic and Schwannian stromal cells
Autor: Paola Scaruffi, Gian Paolo Tonini, Patrizia Perri, Luca Longo, Claudio Gambini, Stefano Moretti, Andrea Cavazzana, Claudio Di Cristofano, Simona Coco, Stefano Bonassi, Raffaella Defferrari, Katia Mazzocco
Publikováno v: The Journal of Pathology. 207:346-357
Neuroblastic tumours are a group of paediatric cancers with marked morphological heterogeneity. Neuroblastoma (Schwannian stroma-poor) (NB-SP) is composed of undifferentiated neuroblasts. Ganglioneuroblastoma intermixed (Schwannian stroma-rich) (GNBi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3b9123dad68a11483a36f2495eb6ca
https://doi.org/10.1002/path.1843
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