Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Raffaella Chiaramonte"'
Publikováno v:
Cancers, Vol 16, Iss 16, p 2861 (2024)
Cutaneous melanoma still represents a significant health burden worldwide, being responsible for the majority of skin cancer deaths. Key advances in therapeutic strategies have significantly improved patient outcomes; however, most patients experienc
Externí odkaz:
https://doaj.org/article/9d09ef4bbd61497b8ba353dd4dc279aa
Autor:
Valentina Traini, Giuseppina Fabbiano, Domenica Ronchetti, Ilaria Silvestris, Vanessa Katia Favasuli, Silvia Erratico, Domenica Giannandrea, Tommaso Laurenzi, Luca Palazzolo, Yvan Torrente, Raffaella Chiaramonte, Ivano Eberini, Niccolò Bolli, Antonino Neri, Elisa Taiana
Publikováno v:
HemaSphere, Vol 7, p e229153d (2023)
Externí odkaz:
https://doaj.org/article/bce2a456c32642049b0b045e8698ffa9
Autor:
Vanessa K. Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Giuseppina Fabbiano, Valentina Traini, Katia Todoerti, Silvia Erratico, Alessia Ciarrocchi, Valentina Fragliasso, Domenica Giannandrea, Francesca Tumiatti, Raffaella Chiaramonte, Yvan Torrente, Palma Finelli, Eugenio Morelli, Nikhil C. Munshi, Niccolò Bolli, Antonino Neri, Elisa Taìana
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
DIS3 gene mutations occur in approximately 10% of patients with multiple myeloma (MM); furthermore, DIS3 expression can be affected by monosomy 13 and del(13q), found in roughly 40% of MM cases. Despite the high incidence of DIS3 mutations and deleti
Externí odkaz:
https://doaj.org/article/0b1c35b936fb4637b779ba411fdb0591
Autor:
Natalia Platonova, Elisa Lazzari, Michela Colombo, Monica Falleni, Delfina Tosi, Domenica Giannandrea, Valentina Citro, Lavinia Casati, Domenica Ronchetti, Niccolò Bolli, Antonino Neri, Federica Torricelli, Leslie A. Crews, Catriona H. M. Jamieson, Raffaella Chiaramonte
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14558 (2023)
The NOTCH ligands JAG1 and JAG2 have been correlated in vitro with multiple myeloma (MM) cell proliferation, drug resistance, self-renewal and a pathological crosstalk with the tumor microenvironment resulting in angiogenesis and osteoclastogenesis.
Externí odkaz:
https://doaj.org/article/28e140a94e8549968eb514671c4229a2
Autor:
Elisa Taiana, Cecilia Bandini, Vanessa Katia Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Katia Todoerti, Silvia Erratico, Domenica Giannandrea, Niccolò Bolli, Nicola Amodio, Alessia Ciarrocchi, Raffaella Chiaramonte, Yvan Torrente, Roberto Piva, Antonino Neri
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
Long non-coding RNA NEAT1 is the core structural component of the nuclear paraspeckle (PS) organelles and it has been found to be deregulated in multiple myeloma (MM) patients. Experimental evidence indicated that NEAT1 silencing negatively impacts p
Externí odkaz:
https://doaj.org/article/5df50422a20f42b69d10527cc7bcb1ce
Autor:
Domenica Giannandrea, Natalia Platonova, Michela Colombo, Mara Mazzola, Valentina Citro, Raffaella Adami, Filippo Maltoni, Silvia Ancona, Vincenza Dolo, Ilaria Giusti, Andrea Basile, Anna Pistocchi, Laura Cantone, Valentina Bollati, Lavinia Casati, Elisabetta Calzavara, Mauro Turrini, Elena Lesma, Raffaella Chiaramonte
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events asso
Externí odkaz:
https://doaj.org/article/c195eedfb9354de7a10e37e74ad06210
Autor:
Ilaria Saltarella, Maria Antonia Frassanito, Aurelia Lamanuzzi, Arianna Brevi, Patrizia Leone, Vanessa Desantis, Lucia Di Marzo, Matteo Bellone, Daniele Derudas, Domenico Ribatti, Raffaella Chiaramonte, Maria Teresa Palano, Antonino Neri, Maria Addolorata Mariggiò, Ruggiero Fumarulo, Franco Dammacco, Vito Racanelli, Angelo Vacca, Roberto Ria
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 93-105 (2019)
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM progression. Here, we investigated the role of Notch signaling in the cross talk between ECs and MM cells enabling angiogenesis. MMECs showed higher
Externí odkaz:
https://doaj.org/article/776e69befcdd433b9391b123de9f954c
Autor:
Clara Bernardelli, Silvia Ancona, Melania Lazzari, Antonella Lettieri, Piera Selvaggio, Valentina Massa, Cristina Gervasini, Fabiano Di Marco, Raffaella Chiaramonte, Elena Lesma
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7040 (2022)
Senescence is a stress-response process characterized by the irreversible inhibition of cell proliferation, associated to the acquisition of a senescence-associated secretory phenotype (SASP), that may drive pathological conditions. Lymphangioleiomyo
Externí odkaz:
https://doaj.org/article/c92fda7eefd8481eb3af69df5a29558d
Autor:
Domenica Giannandrea, Valentina Citro, Elena Lesma, Monica Bignotto, Natalia Platonova, Raffaella Chiaramonte
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Bone is the most common site of cancer metastasis and the spread of cancer cells to the bone is associated with poor prognosis, pain, increased risk of fractures, and hypercalcemia. The bone marrow microenvironment is an attractive place for tumor di
Externí odkaz:
https://doaj.org/article/31a3886a74f34f7eb03066fca56faa44
Autor:
Michela Colombo, Silvia Garavelli, Mara Mazzola, Natalia Platonova, Domenica Giannandrea, Raffaella Colella, Luana Apicella, Marialuigia Lancellotti, Elena Lesma, Silvia Ancona, Maria Teresa Palano, Marzia Barbieri, Elisa Taiana, Elisa Lazzari, Andrea Basile, Mauro Turrini, Anna Pistocchi, Antonino Neri, Raffaella Chiaramonte
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to the interactions of malignant plasma cells with the bone marrow (BM) microenvironment. Myeloma cells educate BM cells to support neoplastic cell growth, su
Externí odkaz:
https://doaj.org/article/85ae0254d5694b439cd66c63b07a3f34