Induction of mitochondrial dysfunction and oxidative stress in human fibroblast cultures exposed to serum from septic patients

Autor: Raffaella, Trentadue, Fiore, Flavio, Fabrizia, Massaro, Francesco, Papa, Arcangela, Iuso, Salvatore, Scacco, Luigi, Santacroce, Nicola, Brienza

Publikováno v: In Life Sciences 17 September 2012 91(7-8):237-243

Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases

Autor: Nazzareno Capitanio, M Scivetti, Giuseppe De Michele, Damiano Panelli, Claudia Piccoli, Teresa Rizza, Raffaella Trentadue, Arcangela Iuso, Francesco Papa, Domenico De Rasmo, Vittoria Petruzzella, Enrico Bertini, Salvatore Scacco, Anna Maria Sardanelli, Rita Vitale, Sergio Papa

Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787:502-517

This paper covers genetic and biochemical aspects of mitochondrial bioenergetics dysfunction in hereditary neurological disorders associated with complex I defects. Three types of hereditary complex I dysfunction are dealt with: (i) homozygous mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1bf6d7880b1cdf84814aa74a328ee8
https://doi.org/10.1016/j.bbabio.2008.12.018

The hUPF1-NMD factor controls the cellular transcript levels of different genes of complex I of the respiratory chain

Autor: Anna Maria Sardanelli, Sergio Papa, Damiano Panelli, Alessandro Stella, Francesca Paola Lorusso, Raffaella Trentadue

Publikováno v: Biochimie. 94(12)

In this study the impact of hUPF1 and hUPF2 knockdown on alternative splicing (AS) isoforms of different genes encoding subunits of respiratory chain complex I and complex IV is described. As expected, loss of both hUPF1 and hUPF2 led to impairment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36042f2047bb989aee685142972b9bb
https://pubmed.ncbi.nlm.nih.gov/22889941

Deep sequencing unearths Nuclear mitochondrial Sequences under Leber's hereditary optic neuropathy-associated false heteroplasmic mitochondrial DNA variants

Autor: Claudia Calabrese, Teresa Rizza, Silvana Guerriero, Lucia Artuso, Raffaella Trentadue, Anna Maria Porcelli, Giuseppe Gasparre, Rosalba Carrozzo, Marzia Bianchi, Roberta Piredda, Rosa Dell'Aglio, Marcella Attimonelli, Vittoria Petruzzella

Leber's hereditary optic neuropathy (LHON) is associated with mitochondrial DNA (mtDNA) ND mutations that are mostly homoplasmic. However, these mutations are not sufficient to explain the peculiar features of penetrance and the tissue-specific expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2956e0195a615669d3b8d10e9384ae1c
http://hdl.handle.net/11585/116355

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

Autor: Michele Minuto, Nazzareno Capitanio, Massimo Zeviani, Sergio Papa, Claudia Piccoli, Arcangela Iuso, Raffaella Trentadue, Maria Ripoli, Vittoria Petruzzella, Salvatore Scacco, Francesco Bellomo

Publikováno v: 281 (2006): 10374–10380.
info:cnr-pdr/source/autori:Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, Minuto M, Ripoli M, Capitanio N, Zeviani M, Papa S./titolo:Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I/doi:/rivista:/anno:2006/pagina_da:10374/pagina_a:10380/intervallo_pagine:10374–10380/volume:281

The pathogenic mechanism of a G44A nonsense mutation in the NDUFS4 gene and a C1564A mutation in the NDUFS1 gene of respiratory chain complex I was investigated in fibroblasts from human patients. As previously observed the NDUFS4 mutation prevented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a63ccc6c0376de7a1919d18ce5fc69e
http://www.cnr.it/prodotto/i/12743