Výsledky vyhledávání - "Raffaele Senatore"

Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane

Autor: Vittorio Pace, Raffaele Senatore, Markus Spreitzer, Wolfgang Holzer, Monika Malik

Publikováno v: Organic Letters

The commercially available fluoroiodomethane represents a valuable and effective electrophilic source for transferring the CH2F unit to a series of heteroatom-centered nucleophiles under mild basic conditions. The excellent manipulability offered by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed40a0afba24e65e237c527746dc921
https://doi.org/10.1021/acs.orglett.9b04654

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Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four-Membered Sulfur-Containing Cycles

Autor: Wolfgang Holzer, Vittorio Pace, Monika Malik, Thierry Langer, Raffaele Senatore

Publikováno v: Angewandte Chemie (International ed. in English). 60(47)

A formal CH2 -CH2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle is reported. The logic proposes the consecutive delivery of two single nucleophilic CH2 units to an isothiocyanate-as com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938cfada2cdbd0b3d5ef6e604a813a35
https://pubmed.ncbi.nlm.nih.gov/34534400

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Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent

Autor: Raffaele Senatore, Wolfgang Holzer, Vittorio Pace, Karen de la Vega-Hernández, Margherita Miele, Ernst Urban

Publikováno v: Organic & Biomolecular Chemistry. 17:1970-1978

Thioformamides are easily prepared - under full chemocontrol - through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent. The high electrophilicity of the starting materials enables the straightforward addition of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc283286fb6af853e564121aa77bf25
https://doi.org/10.1039/c8ob02312c

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Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening

Autor: Laura, Ielo, Margherita, Miele, Veronica, Pillari, Raffaele, Senatore, Salvatore, Mirabile, Rosaria, Gitto, Wolfgang, Holzer, Andrés R, Alcántara, Vittorio, Pace

Publikováno v: Organicbiomolecular chemistry. 19(9)

The intrinsic degradative α-elimination of Li carbenoids somehow complicates their use in synthesis as C1-synthons. Nevertheless, we herein report how boosting such an α-elimination is a straightforward strategy for accomplishing controlled ring-op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9973cedf4c39cbe367111ab515debe4e
https://pubmed.ncbi.nlm.nih.gov/33599644

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Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins

Autor: Veronica Pillari, Laura Ielo, Andrés R. Alcántara, Rosaria Gitto, Wolfgang Holzer, Raffaele Senatore, Margherita Miele, Salvatore Mirabile, Vittorio Pace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd128b03043791f1e63d80320f016ede
http://hdl.handle.net/2318/1779576

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Weinreb Amides as Privileged Acylating Agents for Accessing α-Substituted Ketones

Autor: Raffaele Senatore, Laura Ielo, Laura Castoldi, Vittorio Pace, Serena Monticelli

The acylation of α-substituted carbanion-type reagents (MCR1R2X; X = halogen, OR, SR, NR3R4, SeR, etc.) with Weinreb amides constitutes a highly versatile and flexible approach for accessing α-functionalized ketones. In this short review we will pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e4ab3dba488b278ca8f8ce5b702e92
http://hdl.handle.net/2318/1835430

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Synthesis of stable α-fluoromethyl putative carbanions via a chemoselective reduction-monofluoromethylation sequence of diselenides under sustainable conditions

Autor: Wolfgang Holzer, Monika Malik, Vittorio Pace, Raffaele Senatore, Ernst Urban

Publikováno v: Tetrahedron. 85:131921

α-Fluoromethyl selenoethers were prepared through a sequential one-pot diselenide reduction-fluoromethylation with the fluorinated, highly manipulable C1 source ICH2F. The reaction benefited from the employment of the environmentally friendly solven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0659984201d6e5bd1d88338e321516
https://doi.org/10.1016/j.tet.2021.131921

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Straightforward and direct access to β-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines

Autor: Wolfgang Holzer, Vittorio Pace, Raffaele Senatore, Simona Collina, Roberta Listro, Saad Touqeer, Monika Malik

Publikováno v: Tetrahedron. 76:131220

The transfer of a α-methyl phenylseleno carbanion to variously functionalized N-aryl and N-sulfonyl imines is reported. The fast selenium-lithium exchange conducted on a diselenoacetal with n-BuLi enables the generation of the attacking homologative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ed0a110b3eda176dd79f6f0ddc747a
https://doi.org/10.1016/j.tet.2020.131220

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