Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Raffaele Colombo"'
Autor:
Malabika Sen, Audrey Kindsfather, Ludmila Danilova, Feng Zhang, Raffaele Colombo, Matthew G. LaPorte, Brenda F. Kurland, Donna M. Huryn, Peter Wipf, James G. Herman
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 604-617 (2020)
Signal Transducers and Activators of Transcription-3 (STAT3), a potent oncogenic transcription factor, is constitutively activated in lung cancer, but mutations in pathway genes are infrequent. Protein Tyrosine Phosphatase Receptor-T (PTPRT) is an en
Externí odkaz:
https://doaj.org/article/333860db35804967959dcc5164891d1b
Autor:
Raffaele, Colombo, Jamie R, Rich
Publikováno v:
Cancer Cell. 40:1255-1263
Despite a prevailing dogma wherein antibody drug conjugates (ADCs) increase the maximum tolerated dose of potent cytotoxin payloads while lowering the minimum effective dose, mounting clinical evidence argues that the tolerated doses of ADCs are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df76573c36b5b938d61ec5598d0f89
https://doi.org/10.1016/j.ccell.2022.09.016
https://doi.org/10.1016/j.ccell.2022.09.016
Autor:
Cheng-Yueh Ting, Paul T. Kolbeck, Raffaele Colombo, Chacko Chakiath, Megan Rice, Marcello Marelli, R. James Christie
Publikováno v:
Bioconjugate Chemistry. 33:1609-1619
Optimizing the Diels-Alder (DA) reaction for aqueous coupling has resulted in practical methods to link molecules such as drugs and diagnostic agents to proteins. Both normal electron demand (NED) and inverse electron demand (IED) DA coupling schemes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f572cd214e8f438e47da0d94057a1a
https://doi.org/10.1021/acs.bioconjchem.2c00222
https://doi.org/10.1021/acs.bioconjchem.2c00222
Autor:
Graham Garnett, Katina Mak, Renee Duan, Truman Hirkala-Schaefer, Manuel Lasalle, Nichole Escalante, Joy Guedia, Kara Moyes, Sam Lawn, Raffaele Colombo, Jamie Rich, Stuart Barnscher
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4132834160757918e939da119230db75
https://doi.org/10.1136/jitc-2022-sitc2022.1185
https://doi.org/10.1136/jitc-2022-sitc2022.1185
Autor:
Sam Lawn, Andrea Hernandez Rojas, Raffaele Colombo, Dayananda Siddappa, Jodi Wong, Kaylee Wu, Vincent Fung, Dunja Urosev, Luying Yang, Jamie R. Rich, Stuart D. Barnscher
Publikováno v:
Cancer Research. 83:2641-2641
Background: Folate Receptor alpha (FRa) is a validated cell surface cancer target that is prevalently expressed in multiple cancers with high unmet need, including ovarian cancer and other gynecological cancers, while exhibiting minimal expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f860aaaf7b7696930d6eef0971fe49e3
https://doi.org/10.1158/1538-7445.am2023-2641
https://doi.org/10.1158/1538-7445.am2023-2641
Autor:
Li Zhang, Virginia Aragon‐Sanabria, Anusha Aditya, Marcello Marelli, Tianye Cao, Feng Chen, Barney Yoo, Kai Ma, Li Zhuang, Thais Cailleau, Luke Masterson, Melik Z. Turker, Rachel Lee, Gabriel DeLeon, Sebastien Monette, Raffaele Colombo, Ronald J. Christie, Pat Zanzonico, Ulrich Wiesner, J. Anand Subramony, Michelle S. Bradbury
Publikováno v:
Advanced Therapeutics. 6:2370009
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2366174701e42f638cb131a18d71babf
https://doi.org/10.1002/adtp.202370009
https://doi.org/10.1002/adtp.202370009
Autor:
Li Zhang, Virginia Aragon‐Sanabria, Anusha Aditya, Marcello Marelli, Tianye Cao, Feng Chen, Barney Yoo, Kai Ma, Li Zhuang, Thais Cailleau, Luke Masterson, Melik Z. Turker, Rachel Lee, Gabriel DeLeon, Sebastien Monette, Raffaele Colombo, Ronald J. Christie, Pat Zanzonico, Ulrich Wiesner, J. Anand Subramony, Michelle S. Bradbury
Publikováno v:
Advanced Therapeutics. 6:2200209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87089574a1e37b88a2b9c65d77cba46
https://doi.org/10.1002/adtp.202200209
https://doi.org/10.1002/adtp.202200209
Autor:
Raffaele Colombo, Morgan Urello, Alexander Ma, Lucia Xiang, Herren Wu, R. James Christie, Changshou Gao, Norman C. Peterson, Jonathan Boyd, Augustine Joseph
Publikováno v:
Biomacromolecules. 21(9)
Synthetic gene delivery systems employ multiple functions to enable safe and effective transport of DNA to target cells. Here, we describe metabolite-based poly(l-lysine) (PLL) modifiers that improve transfection by imparting both pH buffering and na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194811690d8ba38d8bdb576edc32e18b
https://pubmed.ncbi.nlm.nih.gov/32786528
https://pubmed.ncbi.nlm.nih.gov/32786528
Autor:
R. Jeffrey Neitz, Zhizhou Yue, Neal Jeffrey Green, Shan Li, Stacie L. Bulfer, Tsui-Fen Chou, Raffaele Colombo, James C. Burnett, Matthew G. LaPorte, Peter Wipf, Donna M. Huryn, Michelle R. Arkin, Celeste Alverez, William J. Moore
Publikováno v:
ACS medicinal chemistry letters, vol 9, iss 11
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters
Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a97309d2f36bd3f55226152fc25aff
https://doi.org/10.1021/acsmedchemlett.8b00372
https://doi.org/10.1021/acsmedchemlett.8b00372
Autor:
Matthew G. LaPorte, Peter Wipf, Feng Zhang, Audrey Kindsfather, Ludmila Danilova, Malabika Sen, Donna M. Huryn, Brenda F. Kurland, James G. Herman, Raffaele Colombo
Publikováno v:
Epigenetics
Signal Transducers and Activators of Transcription-3 (STAT3), a potent oncogenic transcription factor, is constitutively activated in lung cancer, but mutations in pathway genes are infrequent. Protein Tyrosine Phosphatase Receptor-T (PTPRT) is an en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e164e320b9ab37a5297905ec1f6bf678
https://pubmed.ncbi.nlm.nih.gov/31595832
https://pubmed.ncbi.nlm.nih.gov/31595832