Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Rafal R. Nazarewicz"'
Autor:
Venkataraman Amarnath, Irene Zagol-Ikapitte, Alexander Panov, Anna Dikalova, Aurelia Vergeade, Frederic T. Billings, Liang Xiao, David G. Harrison, Sean S. Davies, Olivier Boutaud, Rafal R. Nazarewicz, L. Jackson Roberts, Sergey Dikalov, Valery Yermalitsky, Marcos G. Lopez, Mingfang Ao, Vladimir Mayorov
Publikováno v:
Hypertension
Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension, and mitochondria-targeted agents ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a837a006fe2af0b3c3ac487db813d0
https://pubmed.ncbi.nlm.nih.gov/33012204
https://pubmed.ncbi.nlm.nih.gov/33012204
Autor:
William G. McMaster, Anna Dikalova, Hana A. Itani, Alfiya T Bikineyeva, Rafal R. Nazarewicz, Sergey Dikalov, David G. Harrison
Publikováno v:
Hypertension. 67:1218-1227
Vascular superoxide (O˙ 2 - ) and inflammation contribute to hypertension. The mitochondria are an important source of O˙ 2 - ; however, the regulation of mitochondrial O˙ 2 - and the antihypertensive potential of targeting the mitochondria remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c14542e1f937f603042914a1a7ce53
https://doi.org/10.1161/hypertensionaha.115.07085
https://doi.org/10.1161/hypertensionaha.115.07085
Autor:
Joshua P. Fessel, Rafal R. Nazarewicz, Roman Uzhachenko, Anna Dikalova, Hana A. Itani, William G. McMaster, Sergey Dikalov, Jorge L. Gamboa, Charles R. Flynn, David G. Harrison
Publikováno v:
Circulation research. 121(5)
Rationale: Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by 65 years of age paralleling the increased incidence of hypertension and metabolic conditions further inactivate Sirt3 because of increased NADH (nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f4ac51fb0a9f3537f2042890d924d
https://pubmed.ncbi.nlm.nih.gov/28684630
https://pubmed.ncbi.nlm.nih.gov/28684630
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H1131-H1140
Superoxide (O2·−) production by the NADPH oxidases is implicated in the pathogenesis of many cardiovascular diseases, including hypertension. We have previously shown that activation of NADPH oxidases increases mitochondrial O2·−which is inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28413b2338bc80a42e2f01c2fbd88656
https://doi.org/10.1152/ajpheart.00063.2013
https://doi.org/10.1152/ajpheart.00063.2013
Autor:
Sergey Dikalov, Rafal R. Nazarewicz
Publikováno v:
Antioxidants & Redox Signaling. 19:1085-1094
Significance: The role of reactive oxygen species (ROS) in angiotensin II (AngII) induced endothelial dysfunction, cardiovascular and renal remodeling, inflammation, and fibrosis has been well documented. The molecular mechanisms of AngII pathophysio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ec15d514999828c73838981442737c
https://doi.org/10.1089/ars.2012.4604
https://doi.org/10.1089/ars.2012.4604
Autor:
Anna Dikalova, Sergey Dikalov, Alfiya Bikineyeva, Igor A. Grigor'ev, Igor A. Kirilyuk, Sergey Ivanov, Rafal R. Nazarewicz
Publikováno v:
Antioxidants & Redox Signaling. 19:344-349
It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) attenuates cancer development; however, the exact mechanism remains unclear. In this work, we have studied the direct effect of the mitochondria-targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a36842123379072fb0a7a3753bf8c5
https://doi.org/10.1089/ars.2013.5185
https://doi.org/10.1089/ars.2013.5185
Publikováno v:
Brain Research Bulletin. 90:35-42
Ascorbic acid enhances synthesis of norepinephrine from dopamine in adrenal chromaffin cells by serving as a co-factor for chromaffin granule dopamine β-hydroxylase (DβH). However, there is controversy regarding in situ kinetics of the ascorbate ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100ecb8de4099e30dabee5c9fd35be58
https://doi.org/10.1016/j.brainresbull.2012.09.009
https://doi.org/10.1016/j.brainresbull.2012.09.009
Autor:
Daniel J. Moore, Wei Chen, William G. McMaster, Cornelia M. Weyand, Hana A. Itani, Rachel H. Bonami, Meena S. Madhur, Greg Poffenberger, David G. Harrison, Rafal R. Nazarewicz, Tomasz Mikolajczyk, Andrew F. Marshall, Andrzej Januszewicz, Mohamed A. Saleh, Anna M. Kaszuba, Anna Konior, Allison E. Norlander, Tomasz J. Guzik, Aleksander Prejbisz
Emerging evidence supports an important role for T cells in the genesis of hypertension. Because this work has predominantly been performed in experimental animals, we sought to determine whether human T cells are activated in hypertension. We used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11ff6cc27d043a9b46dfcbfdf4ab7fd
https://ruj.uj.edu.pl/xmlui/handle/item/95524
https://ruj.uj.edu.pl/xmlui/handle/item/95524
Autor:
Lula Hilenski, Gloria Salazar, Nikolay Patrushev, Shiqin Xiong, R. Wayne Alexander, Alejandra San Martin, Rafal R. Nazarewicz
Publikováno v:
Journal of Biological Chemistry. 286:2886-2895
Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells (VSMCs). Conventional wisdom asserts that Akt activation occurs mainly in plasma membrane do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27629a39a933085e7cb13e1009ef21d
https://doi.org/10.1074/jbc.m110.141499
https://doi.org/10.1074/jbc.m110.141499
Publikováno v:
Biochemical and Biophysical Research Communications. 366:23-28
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0621f8944ffc1addf872744d36ec16f1
https://doi.org/10.1016/j.bbrc.2007.11.056
https://doi.org/10.1016/j.bbrc.2007.11.056