Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Rafal Pawlinski"'
Autor:
Jine Li, Erica M. Sparkenbaugh, Guowei Su, Fuming Zhang, Yongmei Xu, Ke Xia, Pen He, Sultan Baytas, Shannon Pechauer, Anand Padmanabhan, Robert J. Linhardt, Rafal Pawlinski, Jian Liu
Publikováno v:
ACS Central Science, Vol 6, Iss 7, Pp 1199-1207 (2020)
Externí odkaz:
https://doaj.org/article/3da4d36d74f546be83a6f819b6f42763
Autor:
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 789-798 (2020)
Abstract Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation
Externí odkaz:
https://doaj.org/article/ef9e3503ced04bb0a1cc394be1c50aa8
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 518-523 (2020)
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is becoming one of the largest global public health crises in modern history. The race for an effective drug to prevent or treat the infection is the highest priority among health care provi
Externí odkaz:
https://doaj.org/article/7db446f535f648a38ff66c60f037add3
Autor:
Steven P. Grover, Clare M. Schmedes, Alyson C. Auriemma, Emily Butler, Molly L. Parrish, Adam Miszta, Audrey C. Cleuren, Mayken Visser, Stefan Heitmeier, Jens J. Posma, Henri M. Spronk, Silvio Antoniak, Alisa S. Wolberg, Rafal Pawlinski, David Gailani, Nigel Mackman
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 207-216 (2020)
Abstract: The intrinsic tenase complex (FIXa-FVIIIa) of the intrinsic coagulation pathway and, to a lesser extent, thrombin-mediated activation of FXI, are necessary to amplify tissue factor (TF)-FVIIa–initiated thrombin generation. In this study,
Externí odkaz:
https://doaj.org/article/865ba4a864934f76b878406b948ce0ba
Autor:
Anton Ilich, Denis F. Noubouossie, Michael Henderson, Patrick Ellsworth, Kathleen F. Molitor, Elena Campello, Shannon Meeks, Amy Dunn, Myung S. Park, Rafal Pawlinski, Paolo Simioni, Amy Shapiro, Nigel S. Key
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 46-53 (2020)
Abstract Numerous methods for evaluation of global fibrinolytic activity in whole blood or plasma have been proposed, with the majority based on tissue‐type plasminogen activator (t‐PA) addition to initiate fibrinolysis. We propose that such an a
Externí odkaz:
https://doaj.org/article/900e4ab51d71429d996a029b893c09f7
Autor:
Erica M. Sparkenbaugh, Pichika Chantrathammachart, Shaobin Wang, Will Jonas, Daniel Kirchhofer, David Gailani, Andras Gruber, Raj Kasthuri, Nigel S. Key, Nigel Mackman, Rafal Pawlinski
Publikováno v:
Haematologica, Vol 100, Iss 3 (2015)
An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation a
Externí odkaz:
https://doaj.org/article/01f071f6f1ee40d1b90e08c07c983b51
Autor:
Silvio Antoniak, Erica M Sparkenbaugh, Michael Tencati, Mauricio Rojas, Nigel Mackman, Rafal Pawlinski
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81733 (2013)
Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of
Externí odkaz:
https://doaj.org/article/262e797676504341b4dff66efc4d7075
Autor:
Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renné, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski
Publikováno v:
Blood. 141:1871-1883
Data are available on request from the corresponding author, R. Pawlinski (rafal_pawlinski@med.unc.edu). The online version of this article contains a data supplement. The American Society of Hematology A hypercoagulable state, chronic inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8009b33648b9b3ce7fb9415ee11f58c8
https://doi.org/10.1182/blood.2022017074
https://doi.org/10.1182/blood.2022017074
Publikováno v:
Physiology. 38
Background: Sickle cell disease (SCD) is an autosomal recessive blood disorder caused by mutations in the β-globin gene, resulting in hemoglobin S (HbS) polymerization and red blood sickling. SCD patients carry two copies of the mutant HbS (HbSS) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47eafc70fd7ef5f9fa8c347aad1e9bc4
https://doi.org/10.1152/physiol.2023.38.s1.5731525
https://doi.org/10.1152/physiol.2023.38.s1.5731525
Autor:
Jun Wan, Pansakorn Tanratana, Mark Roest, Andras Gruber, Rafal Pawlinski, Alisa S. Wolberg, Nigel Mackman, Steven P. Grover
Publikováno v:
Blood advances.
Thrombin generation (TG) assays serve as a valuable tool to study the amplifying roles of intrinsic pathway factors in human coagulation and provide functional insights into the increased bleeding observed in individuals deficient in factors (F) XI,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665fa46f180812068050fbd6dc12ec5f
https://pubmed.ncbi.nlm.nih.gov/36583671
https://pubmed.ncbi.nlm.nih.gov/36583671