High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

Autor: Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh

Publikováno v: npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)

Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays

Externí odkaz: https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab

Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni.

Autor: Thiago Almeida Pereira, Wing-Kin Syn, Frederico Figueiredo Amâncio, Pedro Henrique Diniz Cunha, Julia Fonseca Morais Caporali, Guilherme Vaz de Melo Trindade, Elisângela Trindade Santos, Márcia Maria Souza, Zilton Araújo Andrade, Rafal P Witek, William Evan Secor, Fausto Edmundo Lima Pereira, José Roberto Lambertucci, Anna Mae Diehl

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005057 (2016)

Symptomatic acute schistosomiasis mansoni is a systemic hypersensitivity reaction against the migrating schistosomula and mature eggs after a primary infection. The mechanisms involved in the pathogenesis of acute schistosomiasis are not fully elucid

Externí odkaz: https://doaj.org/article/87e6146f05e549bbb4c479640be480d8

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.

Autor: George M Philips, Isaac S Chan, Marzena Swiderska, Vanessa T Schroder, Cynthia Guy, Gamze F Karaca, Cynthia Moylan, Talaignair Venkatraman, Sebastian Feuerlein, Wing-Kin Syn, Youngmi Jung, Rafal P Witek, Steve Choi, Gregory A Michelotti, Fatima Rangwala, Elmar Merkle, Christopher Lascola, Anna Mae Diehl

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e23943 (2011)

Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop chronic fibrosing liver injury. Hepatocellular carcinoma (HCC) emerges spontaneously i

Externí odkaz: https://doaj.org/article/16dd751bd6f9486994806d16ba3f85eb

Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Autor: Thiago A. Pereira, Isaac S. Chan, Márcia Maria de Souza, Wing-Kin Syn, Vivian Resende, Steve S. Choi, Alba Otoni, Mariana Verdelho Machado, Anna Mae Diehl, Guilherme Vaz de Melo Trindade, Paula Vieira Teixeira Vidigal, Elisângela Trindade Santos, Izabela Voieta, William Evan Secor, Rafal P. Witek, Zilton A. Andrade, José Roberto Lambertucci, Guanhua Xie, Fausto Edmundo Lima Pereira

Publikováno v: Clinical Science (London, England : 1979)

Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. The numbers of OPN-producing bile ductules correlate with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e200bb7efef21c35d40d03bba0b59b
https://doi.org/10.1042/cs20150117

Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni

Autor: William Evan Secor, Zilton A. Andrade, Márcia Maria de Souza, Pedro Henrique Diniz Cunha, Rafal P. Witek, Fausto Edmundo Lima Pereira, Thiago A. Pereira, Júlia Fonseca de Morais Caporali, Wing-Kin Syn, José Roberto Lambertucci, Elisângela Trindade Santos, Anna Mae Diehl, Frederico Figueiredo Amâncio, Guilherme Vaz de Melo Trindade

Publikováno v: PLoS Neglected Tropical Diseases
Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005057 (2016)

Background Symptomatic acute schistosomiasis mansoni is a systemic hypersensitivity reaction against the migrating schistosomula and mature eggs after a primary infection. The mechanisms involved in the pathogenesis of acute schistosomiasis are not f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a22fc97d4dc112f757a8da16ee20ac
https://pubmed.ncbi.nlm.nih.gov/27755536