Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rafal Czapiewski"'
Autor:
Rafal Czapiewski, Dzmitry G. Batrakou, Jose I. de las Heras, Roderick N. Carter, Aishwarya Sivakumar, Magdalena Sliwinska, Charles R. Dixon, Shaun Webb, Giovanna Lattanzi, Nicholas M. Morton, Eric C. Schirmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Little is known how spatial genome organization is directed in fat; however, key proadipogenic genes reposition from the nuclear envelope (NE) to the interior during adipogenesis. Here the authors show that deletion of NE protein Tmem120a in adipocyt
Externí odkaz:
https://doaj.org/article/5efba97324ba4758897fa78e06687621
Autor:
Krishna C. Mudumbi, Rafal Czapiewski, Andrew Ruba, Samuel L. Junod, Yichen Li, Wangxi Luo, Christina Ngo, Valentina Ospina, Eric C. Schirmer, Weidong Yang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization
Externí odkaz:
https://doaj.org/article/3d614e823838402aa8b9ff0997e812ae
Autor:
Peter Meinke, Alastair R.W. Kerr, Rafal Czapiewski, Jose I. de las Heras, Charles R. Dixon, Elizabeth Harris, Heike Kölbel, Francesco Muntoni, Ulrike Schara, Volker Straub, Benedikt Schoser, Manfred Wehnert, Eric C. Schirmer
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes. We applied this to Emery-Dreifuss muscular dystrophy (EDMD), characterised by early onset c
Externí odkaz:
https://doaj.org/article/e946bd122b21483d83d43af02176d4fb
Autor:
Natalia Saiz-Ros, Rafal Czapiewski, Ilaria Epifano, Andrew Stevenson, Selene K. Swanson, Charles R. Dixon, Dario B. Zamora, Marion McElwee, Swetha Vijayakrishnan, Christine A. Richardson, Li Dong, David A. Kelly, Lior Pytowski, Martin W. Goldberg, Laurence Florens, Sheila V. Graham, Eric C. Schirmer
Publikováno v:
Cells, Vol 8, Iss 2, p 120 (2019)
The primary envelopment/de-envelopment of Herpes viruses during nuclear exit is poorly understood. In Herpes simplex virus type-1 (HSV-1), proteins pUL31 and pUL34 are critical, while pUS3 and some others contribute; however, efficient membrane fusio
Externí odkaz:
https://doaj.org/article/c41c1533b52c4d7e86870eed76c105f9
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127712 (2015)
Recent work indicates that the nuclear envelope is a major signaling node for the cell that can influence tissue differentiation processes. Here we present two nuclear envelope trans-membrane proteins TMEM120A and TMEM120B that are paralogs encoded b
Externí odkaz:
https://doaj.org/article/e2e861eb9925477c807370bf129105d0
Autor:
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52989 (2013)
Most cancer cells express high levels of telomerase and proliferate indefinitely. In addition to its telomere maintenance function, telomerase also has a pro-survival function resulting in an increased resistance against DNA damage and decreased apop
Externí odkaz:
https://doaj.org/article/dd3634b84a304de89f73e0896e5700a1
Autor:
Jose I de las Heras, Vanessa Todorow, Lejla Krečinić-Balić, Stefan Hintze, Rafal Czapiewski, Shaun Webb, Benedikt Schoser, Peter Meinke, Eric C Schirmer
Publikováno v:
De Las Heras, J I, Todorow, V, Krečinić-Balić, L, Hintze, S, Czapiewski, R, Webb, S, Schoser, B, Meinke, P & Schirmer, E C 2022, ' Metabolic, fibrotic, and splicing pathways are all altered in Emery-Dreifuss muscular dystrophy spectrum patients to differing degrees ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddac264
Emery-Dreifuss muscular dystrophy (EDMD) is a genetically and clinically variable disorder. Previous attempts to use gene expression changes find its pathomechanism were unavailing, so we here engaged a functional pathway analysis. RNA-Seq was perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba4ec0e794cb2bd15a384020363cca4
https://doi.org/10.1101/2022.05.20.492778
https://doi.org/10.1101/2022.05.20.492778
Autor:
Sheila Webb, de las Heras Ji, Rafal Czapiewski, Giovanna Lattanzi, Dzmitry G. Batrakou, Charles R. Dixon, Eric C. Schirmer, Nik M. Morton, Sliwinska M, Aishwarya Sivakumar, Carter Rn
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Little is known about how the observed fat-specific pattern of 3D-spatial genome organisation is established. Here we report that adipocyte-specific knockout of the gene encoding nuclear envelope transmembrane protein Tmem120a disrupts fat genome org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a26f1720d339a4c3da5dbed9a5c707
http://europepmc.org/articles/PMC8758788
http://europepmc.org/articles/PMC8758788
Autor:
Eric C. Schirmer, E. Harris, Ulrike Schara, Manfred Wehnert, Benedikt Schoser, Peter Meinke, Alastair R.W. Kerr, Francesco Muntoni, Heike Kölbel, Volker Straub, Rafal Czapiewski, Charles R. Dixon, Jose I. de las Heras
Publikováno v:
EBioMedicine, Vol 51, Iss, Pp-(2020)
EBioMedicine
EBioMedicine
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes. We applied this to Emery-Dreifuss muscular dystrophy (EDMD), characterised by early onset c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef5dfbe22018adf60bcf53a27619802
http://www.sciencedirect.com/science/article/pii/S2352396419307972
http://www.sciencedirect.com/science/article/pii/S2352396419307972