Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rafah Allobawi"'
Autor:
Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M. Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G. Rao, Jian Li, Kathryn E. Holt, Tony Velkov
Publikováno v:
mSystems, Vol 9, Iss 1 (2024)
ABSTRACTNitrofurantoin is a commonly used chemotherapeutic agent in the treatment of uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram-negative pathogen Klebsiella pneumoniae. The present study aims to elucidat
Externí odkaz:
https://doaj.org/article/a020996758a44aecb63f2ae7a08f1d44
Autor:
Maytham Hussein, Sara Oberrauch, Rafah Allobawi, Linda Cornthwaite-Duncan, Jing Lu, Rajnikant Sharma, Mark Baker, Jian Li, Gauri G. Rao, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6067-6077 (2022)
There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics
Externí odkaz:
https://doaj.org/article/cc10edd91d624340b9335629527d490a
Autor:
Maytham Hussein, Labell J.M. Wong, Jinxin Zhao, Vanessa E. Rees, Rafah Allobawi, Rajnikant Sharma, Gauri G. Rao, Mark Baker, Jian Li, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1077-1087 (2022)
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen causing nosocomial infections. K. pneumoniae rapidly acquires antibiotic resistance and is known as a reservoir for resistance genes. Polymyxins remain effective as a last-line therapy
Externí odkaz:
https://doaj.org/article/af71853ef9784f8183b9c282686bd8b7
Autor:
Maytham Hussein, Rafah Allobawi, Irini Levou, Mark A. T. Blaskovich, Gauri G. Rao, Jian Li, Tony Velkov
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 786 (2022)
Polymyxins have resurged as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As reports of polymyxin resistance in A. baumannii with monotherapy have become increasingly common, combination therapy is usually the only
Externí odkaz:
https://doaj.org/article/64ac89b305bd40c3acb3ceb479be1c7d
Autor:
Jing Lu, Yan Zhu, Helena C. Parkington, Maytham Hussein, Jinxin Zhao, Phillip Bergen, David Rudd, Mary A. Deane, Sara Oberrauch, Linda Cornthwaite-Duncan, Rafah Allobawi, Rajnikant Sharma, Gauri Rao, Jian Li, Tony Velkov
Publikováno v:
Molecular neurobiologyReferences.
Intraventricular or intrathecal administration of polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria caused infections in the central nervous system (CNS). However, our limited knowledge of the mechanisms under
Autor:
Yan Zhu, Qi Tony Zhou, Simon Crawford, Olivia K. A. Paulin, Rafah Allobawi, Adil Hanif, Jian Li, Mark Baker, Maytham Hussein, Elena K Schneider-Futschik, Tony Velkov
Publikováno v:
ACS Infectious Diseases. 6:1436-1450
This study aimed to investigate synergistic antibacterial activity of polymyxin B in combination with the selective serotonin reuptake inhibitor, sertraline, against the Gram-negative pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Pseu
Publikováno v:
ACS Pharmacology & Translational Science. 3:433-443
We have demonstrated that ivacaftor displays synergistic antibacterial activity in combination with polymyxin B against polymyxin-resistant Pseudomonas aeruginosa that commonly colonizes the lungs of people with cystic fibrosis (CF). However, the und
Autor:
Maytham, Hussein, Labell J M, Wong, Jinxin, Zhao, Vanessa E, Rees, Rafah, Allobawi, Rajnikant, Sharma, Gauri G, Rao, Mark, Baker, Jian, Li, Tony, Velkov
Publikováno v:
Computational and structural biotechnology journal. 20