Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis

Autor: Daniela P. Lage, Rafaella R Costa, Gabriela Silva Ramos, João A. Oliveira-da-Silva, Débora V.C. Mendonça, Rodrigo Maia de Pádua, Bruno Mendes Roatt, Rory Cristiane Fortes de Brito, Fernanda F. Ramos, Priscilla R. V. Campana, Fernão Castro Braga, Camila S. Freitas, Amanda S. Machado, Fernanda Ludolf, Luciana M.R. Antinarelli, Flaviano Melo Ottoni, Miguel A. Chávez-Fumagalli, Elaine Soares Coimbra, Thiago A.R. Reis, Vinicio T.S. Coelho, Maria Victoria Humbert, Jennifer Munkert, Vívian T. Martins, Grasiele S.V. Tavares, Eduardo A.F. Coelho

Publikováno v: Parasitology Research

Treatment for visceral leishmaniasis (VL) is hampered mainly by drug toxicity, their high cost, and parasite resistance. Drug development is a long and pricey process, and therefore, drug repositioning may be an alternative worth pursuing. Cardenolid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0427928eb7a91299782d1e74eab081
https://doi.org/10.1007/s00436-020-06971-2

In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Autor: Amanda S. Machado, Mariana C. Duarte, Priscilla R. V. Campana, Luciana M.R. Antinarelli, Bruno Mendes Roatt, Rory Cristiane Fortes de Brito, João A. Oliveira-da-Silva, Rafaella R Costa, Denise Utsch Gonçalves, Rodrigo Maia de Pádua, Fernão Castro Braga, Flaviano Melo Ottoni, Daniela P. Lage, Camila S. Freitas, Fernanda F. Ramos, Débora V.C. Mendonça, Fernanda Ludolf, Miguel A. Chávez-Fumagalli, Elaine Soares Coimbra, Gabriela Silva Ramos, Grasiele S.V. Tavares, Eduardo A.F. Coelho, Thiago A.R. Reis, Vívian T. Martins, Jennifer Munkert

Publikováno v: Parasite
Parasite, Vol 28, p 38 (2021)

Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684c66fe0cea4caf4d4e8faa884742a5
http://europepmc.org/articles/PMC8045677

Genomics, Proteomics, and Antifungal Activity of Chitinase from the Antarctic Marine Bacterium Curtobacterium sp. CBMAI 2942.

Autor: Vasquez YMS; Divisão de Recursos Microbianos, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia 13148-218, SP, Brazil.; Institute of Biology, Campinas State University (UNICAMP), Campinas 13083-970, SP, Brazil., Cueva-Yesquen LG; Divisão de Recursos Microbianos, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia 13148-218, SP, Brazil.; Institute of Biology, Campinas State University (UNICAMP), Campinas 13083-970, SP, Brazil., Duarte AWF; Complexo de Ciências Médicas e de Enfermagem, Universidade Federal de Alagoas, Campus Arapiraca, Arapiraca 57309-005, AL, Brazil., Rosa LH; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Valladão R; Laboratory of Biochemistry, Instituto Butantan, São Paulo 05585-000, SP, Brazil., Lopes AR; Laboratory of Biochemistry, Instituto Butantan, São Paulo 05585-000, SP, Brazil., Costa Bonugli-Santos R; Instituto Latino Americano de Ciências da Vida e da Natureza (ILACVN), Universidade Federal da Integração Latino-Americana (UNILA), Foz do Iguaçu 85870-650, PR, Brazil., Oliveira VM; Divisão de Recursos Microbianos, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia 13148-218, SP, Brazil.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 26; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 26.