The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi

Autor: Wagner Luiz Pereira, Raphael de Souza Vasconcellos, Christiane Mariotini-Moura, Rodrigo Saar Gomes, Rafaela de Cássia Firmino, Adalberto Manoel da Silva, Abelardo Silva Júnior, Gustavo Costa Bressan, Márcia Rogéria Almeida, Luís Carlos Crocco Afonso, Róbson Ricardo Teixeira, Juliana Lopes Rangel Fietto

Publikováno v: Molecules, Vol 20, Iss 12, Pp 22435-22444 (2015)

Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of

Externí odkaz: https://doaj.org/article/dbd1ae77d8244d8eafbf4d78feb7a9d1

Label-free assay based on immobilized capillary enzyme reactor of Leishmania infantum nucleoside triphosphate diphosphohydrolase ( Lic NTPDase-2-ICER-LC/UV)

Autor: Raphael de Souza Vasconcellos, Juliana Lopes Rangel Fietto, Carmen Lúcia Cardoso, Rafaela de Cássia Firmino, Luana Magalhães, Christiane Mariotini-Moura, Arthur Henrique Cavalcante de Oliveira

Publikováno v: LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV

Nucleoside triphosphate diphosphohydrolase (NTPDase) is an enzyme belonging to the apyrase family that participates in the hydrolysis of the nucleosides di- and triphosphate to the corresponding nucleoside monophosphate. This enzyme underlies the vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f130b5dad0b2d6030a87f385be6fd517
https://doi.org/10.1016/j.jchromb.2015.11.028

Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apyrase involved in macrophage infection and expressed in infected dogs

Autor: Aimara da Costa Pinheiro, Gabriel Andrés Tafur Gomez, Rodrigo Saar Gomes, Munira Muhammad Abdel Baqui, Gustavo Costa Bressan, Abelardo Silva-Júnior, Lucas Borges-Pereira, Anna Cláudia Alves de Souza, Matheus Silva e Bastos, Ronny Francisco de Souza, Luís Carlos Crocco Afonso, Márcia Rogéria de Almeida, Rafaela de Cássia Firmino, Christiane Mariotini-Moura, Claudia Miranda de Oliveira, Tiago D. Serafim, Talles Eduardo Ferreira Maciel, Felipe Freitas de Castro, Raphael de Souza Vasconcellos, Juliana Lopes Rangel Fietto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3309 (2014)

Background Visceral leishmaniasis is an important tropical disease, and Leishmania infantum chagasi (synonym of Leishmania infantum) is the main pathogenic agent of visceral leishmaniasis in the New World. Recently, ecto-nucleoside triphosphate dipho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e2d9747e4caae38d31386ec04edd32