Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Rafael S. Costa"'
Publikováno v:
BMC Medical Genomics, Vol 16, Iss S1, Pp 1-14 (2023)
Abstract Background Despite the advancements in multiagent chemotherapy in the past years, up to 10% of Hodgkin’s Lymphoma (HL) cases are refractory to treatment and, after remission, patients experience an elevated risk of death from all causes. T
Externí odkaz:
https://doaj.org/article/51478848ae604ef1a7c078b2ddaf77d1
Publikováno v:
AI, Vol 4, Iss 1, Pp 303-318 (2023)
In this paper, a computational framework is proposed that merges mechanistic modeling with deep neural networks obeying the Systems Biology Markup Language (SBML) standard. Over the last 20 years, the systems biology community has developed a large n
Externí odkaz:
https://doaj.org/article/91893d6259ff4857a5c3514bab50c581
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Hybrid modeling combining First-Principles with machine learning is becoming a pivotal methodology for Biopharma 4.0 enactment. Chinese Hamster Ovary (CHO) cells, being the workhorse for industrial glycoproteins production, have been th
Externí odkaz:
https://doaj.org/article/f2f3ed691a3c4435b69a016c5e18c1be
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 95, Iss suppl 1 (2023)
Abstract This study evaluated the technological viability of yogurt with the addition of green-banana biomass (Musa spp.) considering the resistant starch (BBV) as a potential prebiotic ingredient and texture agent. Four yogurt formulations were prep
Externí odkaz:
https://doaj.org/article/cc88a8f6fc8c40d58d538beb425c7ccf
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4960-4973 (2023)
The accurate prediction of phenotypes in microorganisms is a main challenge for systems biology. Genome-scale models (GEMs) are a widely used mathematical formalism for predicting metabolic fluxes using constraint-based modeling methods such as flux
Externí odkaz:
https://doaj.org/article/06ecb2d3862c4373ba01418cda63f9e0
Publikováno v:
Fractal and Fractional, Vol 7, Iss 8, p 595 (2023)
Cancer is a complex disease, responsible for a significant portion of global deaths. The increasing prioritisation of know-why over know-how approaches in biological research has favoured the rising use of both white- and black-box mathematical techn
Externí odkaz:
https://doaj.org/article/fcec83d58e7e413a9bab838f5283470c
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background A considerable number of data mining approaches for biomedical data analysis, including state-of-the-art associative models, require a form of data discretization. Although diverse discretization approaches have been proposed, the
Externí odkaz:
https://doaj.org/article/af27f84c10fc4fab8eb2d47253a3a1af
Publikováno v:
Fermentation, Vol 9, Iss 7, p 643 (2023)
Hybrid modeling workflows combining machine learning with mechanistic process descriptions are becoming essential tools for bioprocess digitalization. In this study, a hybrid deep modeling method with state–space reduction was developed and showcas
Externí odkaz:
https://doaj.org/article/a8dade0c8dcd492e99020e271c3d7318
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Postoperative complications are still hard to predict despite the efforts towards the creation of clinical risk scores. The published scores contribute for the creation of specialized tools, but with limited predictive performance and reusab
Externí odkaz:
https://doaj.org/article/930adffac7d14750b3fa0005b61aa666
Autor:
Antero Fernandes, Jéssica Rodrigues, Luís Antunes, Patrícia Lages, Carla Salomé Santos, Daniel Moreira-Gonçalves, Rafael S. Costa, Joaquim Abreu Sousa, Mário Dinis-Ribeiro, Lúcio Lara Santos
Publikováno v:
Perioperative Medicine, Vol 9, Iss 1, Pp 1-9 (2020)
Abstract Background Gastrointestinal cancer surgery continues to be a significant cause of postoperative complications and mortality in high-risk patients. It is crucial to identify these patients. Our study aimed to evaluate the accuracy of specific
Externí odkaz:
https://doaj.org/article/216c123258e2423db88fa37d478e3f33