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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.

Autor: Armstrong NJ; Mathematics and Statistics, Murdoch University, Perth, Australia (N.J.A.)., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Sargurupremraj M; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.)., Knol MJ; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU Munich, Germany (R.M., M.D.)., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX (C.L.S., S.S.).; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Yanek LR; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Wen W; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia., Gudnason VG; Icelandic Heart Association, Kopavogur (V.G.G., S.S.).; University of Iceland, Reykjavik, Iceland (V.G.G., A.V.S.)., Dueker ND; Dr. John T. Macdonald Foundation Department of Human Genetics (R.L.S.), University of Miami, FL., Elliott LT; Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada (L.T.E.).; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (E.H., R.S.).; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria (E.H.)., Bis J; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., Jahanshad N; Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey (N.J., P.M.T.)., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Logue MA; Department of Psychiatry and Biomedical Genetics Section (M.A.L.), Boston University School of Medicine, MA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.).; National Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, MA (M.A.L.)., Luciano M; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology (M.S.)., Smith AV; University of Iceland, Reykjavik, Iceland (V.G.G., A.V.S.)., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics (S.T.), Leiden University Medical Center, the Netherlands.; Department of Cardiology (S.T.), Leiden University Medical Center, the Netherlands., Vojinovic D; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX (R.X., M.F.)., Alfaro-Almagro F; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Ames D; National Ageing Research Institute, Parkville, Victoria, Australia (D.A.).; Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, Australia (D.A.)., Amin N; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Amouyel P; Lille University, Inserm, Institut Pasteur de Lille, RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases and Labex Distalz, France (P.A.).; Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, RID-AGE (P.A.)., Beiser AS; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Dementia Centre for Research Collaboration (H.B.), University of New South Wales, Sydney, Australia., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Fennema-Notestine C; Department of Psychiatry (C.F.-N.), University of California, San Diego, La Jolla, CA.; Center for Behavior Genetics of Aging (C.F.-N.), University of California, San Diego, La Jolla, CA., Gampawar PG; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Austria (P.G.G., H.S.)., Gottesman R; Department of Neurology, Cerebrovascular and stroke Division (R.G.), Johns Hopkins University School of Medicine, Baltimore, MD., Griffanti L; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN (C.R.J.J.)., Jenkinson M; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Jiang J; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia., Kral BG; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Kwok JB; School of Medical Sciences (J.B.K., P.R.S.), University of New South Wales, Sydney, Australia.; Brain and Mind Centre - The University of Sydney, Camperdown, NSW, Australia (J.B.K.)., Lampe L; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (L.L., V.A.W.)., C M Liewald D; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Maillard P; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA (P.M.)., Marchini J; Statistical Genetics and Methods at Regeneron Pharmaceuticals, Inc, New York, NY (J.M.)., Bastin ME; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.).; Centre for Clinical Brain Sciences, Edinburgh Imaging, Centre for Cognitive Ageing, University of Edinburgh, United Kingdom (M.E.B., J.M.W.)., Mazoyer B; Institut des Maladies Neurodégénératives, University of Bordeaux, France (B.M.)., Pirpamer L; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (L.P.)., Rafael Romero J; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Roshchupkin GV; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.)., Schofield PR; School of Medical Sciences (J.B.K., P.R.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Schroeter ML; LIFE Research Center for Civilization Disease, Leipzig, Germany (M.S.).; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (M.L.S., A.V.).; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany (M.L.S., A.V.)., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom (D.J.S.)., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Trollor J; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), University of New South Wales, Sydney, Australia., Tzourio C; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.).; CHU de Bordeaux, Public Health Department, Medical information Department, Bordeaux, France (C.T.)., van der Grond J; Department of Radiology (J.v.d.G.), Leiden University Medical Center, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.)., Witte VA; Collaborative Research Center 1052 Obesity Mechanisms, Faculty of Medicine, University of Leipzig, Germany (V.A.W).; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (L.L., V.A.W.)., Wright MJ; Queensland Brain Institute (M.J.W.), The University of Queensland, St Lucia, QLD, Australia.; Centre for Advanced Imaging (M.J.W.), The University of Queensland, St Lucia, QLD, Australia., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Morris Z; Neuroradiology Department, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, United Kingdom (Z.M.)., Siggurdsson S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX (C.L.S., S.S.).; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Psaty B; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., Villringer A; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (M.L.S., A.V.).; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany (M.L.S., A.V.)., Schmidt H; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Austria (P.G.G., H.S.)., Haberg AK; Department of Neuromedicine and Movement Science (A.K.H.), Norwegian University of Science and Technology, Trondheim, Norway.; Department of Radiology and Nuclear Medicine (A.K.H.), Norwegian University of Science and Technology, Trondheim, Norway., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Nuffield Department of Population Health (C.M.v.D.), University of Oxford, United Kingdom., Jukema JW; Department of Cardiology (J.W.J.), Leiden University Medical Center, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, the Netherlands (J.W.J.)., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU Munich, Germany (R.M., M.D.).; German Center for Neurodegenerative Diseases, Munich, Germany (M.D.).; Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.)., Sacco RL; Department of Public Health Sciences, Miller School of Medicine (R.L.S.), University of Miami, FL.; Department of Neurology, Miller School of Medicine (R.L.S.), University of Miami, FL.; Evelyn F. McKnight Brain Institute, Department of Neurology (R.L.S.), University of Miami, FL., Wright CB; National Institute of Neurological Disorders and Stroke (C.B.W.), National Institutes of Health, Bethesda, MD., Kremen WS; Center for Behavior Genetics of Aging (W.S.K.), University of California, San Diego, La Jolla, CA.; Department of Psychiatry (W.S.K.), University of California, San Diego, La Jolla, CA., Becker LC; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Thompson PM; Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey (N.J., P.M.T.)., Mosley TH; Department of Geriatric Medicine, Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson (T.H.M.)., Wardlaw JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.).; Centre for Clinical Brain Sciences, Edinburgh Imaging, Centre for Cognitive Ageing, University of Edinburgh, United Kingdom (M.E.B., J.M.W.)., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.).; Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands (H.H.H.A.)., Seshadri S; Icelandic Heart Association, Kopavogur (V.G.G., S.S.)., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia (P.S.S.)., Smith SM; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Launer L; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program (L.L.), National Institutes of Health, Bethesda, MD., Longstreth W; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., DeCarli C; Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience University of California at Davis (C.D.)., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (E.H., R.S.)., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX (R.X., M.F.).; Human Genetics Center, School of Public Health UT, Houston, TX (M.F.)., Debette S; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.).; Department of Neurology, CHU de Bordeaux (University Hospital), Bordeaux, France (S.D.)., Nyquist PA; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD.; Departments of Neurology, Critical Care Medicine, Neurosurgery (P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD.; Critical Care Medicine Department (P.A.N.), National Institutes of Health, Bethesda, MD.

Publikováno v: Stroke [Stroke] 2020 Jul; Vol. 51 (7), pp. 2111-2121. Date of Electronic Publication: 2020 Jun 10.