Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Rafael R Ariza"'
Autor:
Yan Li, Dolores Córdoba-Cañero, Weiqiang Qian, Xiaohong Zhu, Kai Tang, Huiming Zhang, Rafael R Ariza, Teresa Roldán-Arjona, Jian-Kang Zhu
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004905 (2015)
Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases. Active DNA demethylation in animals requires the DNA glycosylase TDG
Externí odkaz:
https://doaj.org/article/c5aad88acd0145a29423ec3281546793
Autor:
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raúl F. Pérez, Sara López-Tamargo, Ana Díez-Borge, Juan J. Alba-Linares, Nerea González-del-Rey, Rocío G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virginia López, Teresa Morales-Ruiz, Rafael R. Ariza, Teresa Roldán-Arjona, Mónica Meijón, Luis Valledor, María Jesús Cañal, Daniel Fernández-Martínez, María Fernández-Hevia, Paula Jiménez-Fonseca, Luis J. García-Flórez, Agustín F. Fernández, Mario F. Fraga
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or is a mere consequenc
Externí odkaz:
https://doaj.org/article/95cb022c2afa458ba4a52e0c37ea095b
Autor:
María Victoria García-Ortiz, María José de la Torre-Aguilar, Teresa Morales-Ruiz, Antonio Gómez-Fernández, Katherine Flores-Rojas, Mercedes Gil-Campos, Pilar Martin-Borreguero, Rafael R. Ariza, Teresa Roldán-Arjona, Juan Luis Perez-Navero
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
The goal of this investigation was to determine whether there are alterations in DNA methylation patterns in children with autism spectrum disorder (ASD).Material and Methods: Controlled prospective observational case-control study. Within the ASD gr
Externí odkaz:
https://doaj.org/article/65a47e60820a437584875f83e3d0f261
Autor:
Teresa Morales-Ruiz, María Victoria García-Ortiz, Iván Devesa-Guerra, Laura Raya-Ruiz, Juan R. Tejedor, Gustavo F. Bayón, Marta I. Sierra, Mario F. Fraga, Rafael R. Ariza, Teresa Roldán-Arjona
Publikováno v:
Epigenetics, Vol 13, Iss 1, Pp 95-107 (2018)
Patterns of DNA methylation, an important epigenetic modification involved in gene silencing and development, are disrupted in cancer cells. Understanding the functional significance of aberrant methylation in tumors remains challenging, due in part
Externí odkaz:
https://doaj.org/article/716ad87d66bd4c03897422f5f20273f6
Autor:
Marina Jordano-Raya, Cristina Beltrán-Melero, M. Dolores Moreno-Recio, M. Isabel Martínez-Macías, Rafael R. Ariza, Teresa Roldán-Arjona, Dolores Córdoba-Cañero
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8763 (2021)
Abasic (apurinic/apyrimidinic, AP) sites are ubiquitous DNA lesions arising from spontaneous base loss and excision of damaged bases. They may be processed either by AP endonucleases or AP lyases, but the relative roles of these two classes of enzyme
Externí odkaz:
https://doaj.org/article/877ddc6194b64ce4bfdbe6400a8d8d22
Publikováno v:
Epigenetics, Vol 12, Iss 4, Pp 296-303 (2017)
DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication-depe
Externí odkaz:
https://doaj.org/article/cb89ea0cd7e1402093012c5e15b73bae
Autor:
Dolores Córdoba-Cañero, Marina Jordano-Raya, M Dolores Moreno-Recio, Cristina Beltrán-Melero, Teresa Roldán-Arjona, Rafael R. Ariza, M Isabel Martínez-Macías
Publikováno v:
International Journal of Molecular Sciences 22(16), 8763 (2021)
Helvia. Repositorio Institucional de la Universidad de Córdoba
instname
International Journal of Molecular Sciences, Vol 22, Iss 8763, p 8763 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
Helvia. Repositorio Institucional de la Universidad de Córdoba
instname
International Journal of Molecular Sciences, Vol 22, Iss 8763, p 8763 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
Abasic (apurinic/apyrimidinic, AP) sites are ubiquitous DNA lesions arising from spontaneous base loss and excision of damaged bases. They may be processed either by AP endonucleases or AP lyases, but the relative roles of these two classes of enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e647eec2cc6de5e3b9051779bc81f995
http://hdl.handle.net/10396/21703
http://hdl.handle.net/10396/21703
The base excision repair pathway is a critical mechanism that removes non-bulky DNA lesions arising from base oxidation, alkylation, or deamination. Base excision repair is initiated by enzymes called DNA glycosylases that excise the damaged base, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccfbdcbf25bcbaf5aeaae840d434caa5
https://doi.org/10.1039/9781839162541-00048
https://doi.org/10.1039/9781839162541-00048
Autor:
Dolores Córdoba-Cañero, Álvaro C. Romero-Valenzuela, Teresa Morales-Ruiz, Rafael R. Ariza, Vanessa M. Vázquez‐Grande, Teresa Roldán-Arjona
Publikováno v:
DNA Repair. 65:34-41
Base excision repair (BER) is a major defense pathway against spontaneous DNA damage. This multistep process is initiated by DNA glycosylases that recognise and excise the damaged base, and proceeds by the concerted action of additional proteins that
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Abasic (apurinic/apyrimidinic, AP) sites in DNA result from spontaneous and repair-mediated base release. They may be processed by AP endonucleases or AP lyases, but the relative roles of both types of enzymes are poorly understood. Our