Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rafael Peláez-Lamamié de Clairac"'
Autor:
Rafael Peláez-Lamamié de Clairac, Esther Caballero, Manuel Medarde, Heidi Sahagún, Fernando Tomé
Publikováno v:
Tetrahedron. 54:6111-6122
The synthesis of the first representative compound of 7-aryl anthracycline analogues, is described. 1-Alkyl-3-trialkylsiloxydienes, prepared from readily available materials, are transformed through a Diels-Alder cycloaddition into a tetracyclic keto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725ba3d6607abfbbe9ed03dbdcd8b6cf
https://doi.org/10.1016/s0040-4020(98)00304-4
https://doi.org/10.1016/s0040-4020(98)00304-4
Autor:
Esther Caballero, Rafael Peláez-Lamamié de Clairac, Jose Luis López, Arturo San Feliciano, Manuel Medarde, Angel C. Ramos
Publikováno v:
Tetrahedron Letters. 39:2001-2004
A new family of thienolignanolides has been synthesized by means of conjugate addition-alkylation of 5 H -furan-2-one, followed by cyclization and controlled epimerizations. The applicability of this versatile methodology is extended to the preparati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82f05d9fd9660bb789201555780ff63
https://doi.org/10.1016/s0040-4039(98)00116-6
https://doi.org/10.1016/s0040-4039(98)00116-6
Autor:
Esther Caballero, Jose Luis López, Rafael Peláez-Lamamié de Clairac, Angel C. Ramos, Arturo San Feliciano, D. G. Gravalos, Manuel Medarde
Publikováno v:
European Journal of Medicinal Chemistry. 33:71-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917ff1268f912ee3ff497b999f1a2b26
https://doi.org/10.1016/s0223-5234(99)80078-6
https://doi.org/10.1016/s0223-5234(99)80078-6
Autor:
Isabel Barasoain, Rafael Peláez-Lamamié de Clairac, José Manuel Andreu, Esther Caballero, Ana B.S. Maya, Manuel Medarde, Benedicto del Rey
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus-Elsevier
instname
Scopus-Elsevier
The 3,4,5-trimethoxyphenyl and 3-hydroxy-4-methoxyphenyl rings of combretastatin A-4 are deemed optimal for its activity as antimitotic agent. The replacement of either one by a naphthalene ring results in compounds with a potency comparable to that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58ce3806dee0354e29d240005518520
https://doi.org/10.1016/s0960-894x(00)00506-0
https://doi.org/10.1016/s0960-894x(00)00506-0
Autor:
Manuel Medarde, Rafael Peláez-Lamamié de Clairac, Fernando Tomé, Esther Caballero, Marta Adeva, Heidi Sahagún
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4102a32c174f88ada5e84833f908cab2
https://doi.org/10.1002/chin.200037126
https://doi.org/10.1002/chin.200037126
Autor:
Rafael Peláez-Lamamié de Clairac, Marta Adeva, Esther Caballero, Heidi Sahagún, Fernando Tomé, and Manuel Medarde
Publikováno v:
The Journal of organic chemistry. 65(11)
The preparation of a range of open analogues of arcyriaflavin A is described. The synthetic approach is based on the use of perhydroisoindole-1,3,5-triones as key intermediates, which were obtained via Diels-Alder methodology using 1-aryl-3-siloxy-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6509289a4aed15975027e91f3b570c
https://pubmed.ncbi.nlm.nih.gov/10843621
https://pubmed.ncbi.nlm.nih.gov/10843621
Autor:
Dolores Ga Grávalos, Jose Luis López, Manuel Medarde, Arturo San Feliciano, Rafael Peláez-Lamamié de Clairac
Publikováno v:
Archiv der Pharmazie. 328(9)
Several chloro- and iodo-lignanolides have been obtained by direct halogenation of aromatic rings from yatein and 4'-O-demethylyatein. They were assayed as antineoplastics, in order to check the influence in the activity of substitution in both aroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deca5f268eed3033bc54def64fa638a4
https://pubmed.ncbi.nlm.nih.gov/7487420
https://pubmed.ncbi.nlm.nih.gov/7487420
Publikováno v:
HETEROCYCLES. 51:1443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1dda0b37460612498f0fcdb4d6cfa8c
https://doi.org/10.3987/rev-98-514
https://doi.org/10.3987/rev-98-514
Autor:
Arturo San Feliciano, Manuel Medarde, Rafael Peláez-Lamamié de Clairac, Esther Caballero, Angel C. Ramos
Publikováno v:
Scopus-Elsevier
Conjugate addition of lithiated 2-heteroaryl-1, 3-dithianes to furan-2(5H)-one has been successfully achieved. This reaction proceeds with higher yields than the addition of the 2-aryl derivatives, although it fails if the heteroaryl ring has strong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171769cbf29561358f7ab9838b11cf01
https://doi.org/10.1039/p19940000045
https://doi.org/10.1039/p19940000045